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2,087 Possible Causes for 3 kinase, activation, cascade, of, phosphoinositide

  • Osteoporosis

    Moreover, compounds 3, 6-9, and 11 significantly suppressed TRAP activities.[ncbi.nlm.nih.gov] Overexpression of microRNA‑148a significantly reduced estrogen receptor a (ERα) protein expression and suppressed phosphoinositide‑3kinase regulatory subunit 1 (PI3K) and[ncbi.nlm.nih.gov] In all 4patients, teriparatide was effective in halting the fracture cascade, including in the 2patients who remained on long-term glucocorticoid therapy.[ncbi.nlm.nih.gov] It is associated with lower levels of physical activity.[ncbi.nlm.nih.gov] Stop the fracture cascade The risk of future fractures rises with each new fracture - this is known as the 'cascade effect'.[osteoporosis.org.au]

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  • Pasteurella Multocida

    Downstream of Galpha(q), Galpha(13) and Galpha(i), the toxin activates the small GTPase RhoA, MAP kinases and signal transducer and activator of transcription (STAT) proteins[ncbi.nlm.nih.gov] Many signaling pathways have been elucidated, however, the effect of these signaling cascades as a means to subvert the host's immune system are just beginning to unravel.[ncbi.nlm.nih.gov] Pasteurella multocida Toxin (PMT) is a mitogenic protein toxin that manipulates signal transduction cascades of mammalian host cells and upregulates Janus kinase (JAK) and[ncbi.nlm.nih.gov] In addition to standard therapy, the patient was managed with drotrecogin alpha (activated) recombinant activated protein C (APC), an evidence-based agent that has been shown[ncbi.nlm.nih.gov] PMT also stimulates Gbetagamma signalling and activates phosphoinositide 3-kinase (PI3K)-related pathways, which play a crucial role in proliferation and apoptosis.[ncbi.nlm.nih.gov]

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  • Pneumococcal Infection

    Infections of THP-1 cells in the presence of specific pharmacological inhibitors revealed a crucial role of actin polymerization and importance of the phosphoinositide 3-kinase[ncbi.nlm.nih.gov] Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.[ncbi.nlm.nih.gov] A previously healthy 2-year-old boy presented with acute renal failure, thrombocytopenia, microangiopathic hemolytic anemia, pneumococcal infection, and T activation of RBCs[ncbi.nlm.nih.gov] The Y175A CRP does not bind C1q and does not activate complement in human serum. The K114A CRP binds C1q and activates complement more efficiently than wild-type CRP.[ncbi.nlm.nih.gov] The rearrangement of the actin cytoskeleton during phagocytosis, resulting in the engulfment of bacteria, is thereby tightly regulated by receptor-mediated phosphorylation cascades[ncbi.nlm.nih.gov]

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  • Epilepsy

    Excessive extracellular glutamate activates AMPA-type glutamate receptors (AMPA receptors) and induces seizures.[ncbi.nlm.nih.gov] Overexpression of miRNA‑155 resulted in decreased brain‑derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) protein expression, increased caspase‑3[ncbi.nlm.nih.gov] Irisin and chemerin peptides expression are triggered by hypoxia and involved in activation of inflammatory cascades in various organs including the brain; however, their[ncbi.nlm.nih.gov] On 1-year follow-up, patient and family members did not report episodic confusion or any seizure-like activity.[ncbi.nlm.nih.gov] Antagonistic activation of AMPA receptors inhibits epilepsy and glioma growth in in vitro and in vivo studies.[ncbi.nlm.nih.gov]

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  • Astrovirus

    In addition qualitative chemical studies were developed for the active compounds.[ncbi.nlm.nih.gov] Inhibitors of phosphoinositide 3-kinase (PI3K) activation interfered with the infection, independent of their effect on ERK 1/2 activation.[ncbi.nlm.nih.gov] HAstV assembles from the structural protein VP90 and undergoes a cascade of proteolytic cleavages.[pdbj.org] One peptide derivative in particular (E23A) displayed superior inhibition of complement activation in multiple assays of classical complement pathway activation.[ncbi.nlm.nih.gov] Type I interferon (IFN) activation and its subsequent effects are important in the response to viral infections.[ncbi.nlm.nih.gov]

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  • Rosiglitazone

    Here, we investigated the structure-activity relationships (SARs) of PPARγ agonist rosiglitazone, focusing on transrepression activity.[ncbi.nlm.nih.gov] Rosiglitazone significantly promoted endothelial cell migration and induced permeability via activation of phosphatidylinositol-3-kinase (PI3K) - Akt or protein kinase C ([ncbi.nlm.nih.gov] […] predominant intracellular signaling pathways that act downstream of the activated CXCR4/CXCL12 axis, namely the phosphatidyl inositol 3‑kinase (PI3K)‑protein kinase B (Akt) cascades[ncbi.nlm.nih.gov] […] chemiluminescence; IR, insulin receptor; IRS1–4, IR substrate proteins 1–4; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; mpk, mg/kg body weight; PI3K, phosphoinositide[biochemj.org] […] this study suggest that RGZ may exert an anti-apoptotic effect against CPF-induced cytotoxicity by attenuation of oxidative stress as well as inhibition of the inflammatory cascade[ncbi.nlm.nih.gov]

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  • Sorbus

    Both SET and HAT-type activity of the most potent Sorbus extracts was comparable with the activity of the standards, indicating their great potential as effective sources[ncbi.nlm.nih.gov] kinase 1 (PDK1), p85/phosphoinositide-3-kinase (PI3K), as per the results obtained from the reporter gene assay and immunoblotting analysis.[ncbi.nlm.nih.gov] There are intermediate forms on the east side of the Cascades and in the Wallowa Mountains.[nativeplantspnw.com] […] much attention as a molecular target for the treatment of insulin resistance diseases because of its critical roles in negatively regulating insulin- and leptin-signaling cascades[ncbi.nlm.nih.gov] Superoxide radical scavenging activity and DPPH radical scavenging activity were assessed in order to evaluate the antioxidant effect of the Sorbus commixta Hedl. extract[ncbi.nlm.nih.gov]

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  • Doxorubicin

    Inhibition of the protein kinase C (PKC) and phosphoinositide 3 kinase (PI3K) reduced MDR1 gene expression.[ncbi.nlm.nih.gov] Furthermore, mitochondrial dysfunction, cell growth arrest at G0/G1 phase and caspase cascades as well as up- and down-regulated expression levels of related proteins (p21[ncbi.nlm.nih.gov] Anthracyclines induce double-strand DNA breaks at active gene promoters. Mutat Res 773:9-15. See also: Yang F, Kemp CJ, Henikoff S . 2013.[fredhutch.org] The expression levels of CLDN1 and 3 were decreased by LY-294002, a phosphoinositide 3-kinase (PI3K) inhibitor, and BAY 11-7082, an NF-κB inhibitor.[ncbi.nlm.nih.gov] Doxorubicin was found to activate signal transducer and activator of transcription 3 via Src kinase in cancer cells harboring alterations in TP53.[ncbi.nlm.nih.gov]

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  • Salmonella Typhimurium

    However, the antibacterial activity of Colla corii asini has been unknown.[ncbi.nlm.nih.gov] The FDCS PDOX was resistant to both doxorubicin (DOX) and NVP-BEZ235, dactolisib (BEZ) an experimental agent which is a dual pan-phosphoinositide 3-kinase-mammalian target[ncbi.nlm.nih.gov] Cyclically, the reproduction of the trigger sequences and cascade successive production of scaffolds were achieved successfully, forming highly fluorescent AgNCs, thus providing[ncbi.nlm.nih.gov] Typhimurium engages host factors via local manipulation of phosphoinositide composition at the site of invasion to orchestrate the internalization process.[ncbi.nlm.nih.gov] Typhimurium serve as a platform triggering further signalling cascades.[ncbi.nlm.nih.gov]

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  • Yersinia

    The balance between these activating and inhibitory activities shapes the outcome of Yersinia infection.[ncbi.nlm.nih.gov] Many bacterial pathogens subvert mammalian type IA phosphoinositide 3-kinase (PI3K) in order to induce their internalization into host cells.[ncbi.nlm.nih.gov] Binding of invasin-expressing Yersinia to beta1 integrin receptors of epithelial cells induces activation of a signal cascade involving Rac1, MAP kinases, activation of the[ncbi.nlm.nih.gov] After robust in vivo amplification of DCs by injection of Fms-like tyrosine kinase 3-Ligand (Flt3L)-transfected BL16 melanoma, DCs were purified.[ncbi.nlm.nih.gov] In Y. pseudotuberculosis AHL-dependent quorum sensing is involved in the control of cell aggregation and swimming motility, the latter via the flagellar regulatory cascade[ncbi.nlm.nih.gov]

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