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1,724 Possible Causes for 3 kinase, cascade, of, phosphoinositide, upregulation

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  • Activated PI3K-Delta Syndrome

    Contribution of hypoxic upregulation of neutrophil degranulation to airway disease and endothelial dysfunction in COPD Characterisation of a mouse model of the APDS (MRC program[sheffield.ac.uk] Phosphatidylinositol 3-kinase (PI3K) is a critical element in this signaling, it is activated in a wide range of human neoplasms and associated with poor outcomes [ 2 , 3[biomarkerres.biomedcentral.com] Often a cascade of changes occur within the cell which results in a change in the cells function or identity.[docslide.com.br] Medical condition: APDS/PASLI (Activated phosphoinositide 3-kinase delta syndrome/p110δ-activating mutation causing senescent T cells, lymphadenopathy and immunodeficiency[clinicaltrialsregister.eu] PIK3CD promoted proliferation in diffuse large B cell lymphoma through upregulation of c-myc.[journal.frontiersin.org]

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  • Osteoporosis

    The results showed that miR-133a was significantly upregulated and negatively correlated with lumbar spine BMD in serum of postmenopausal osteoporotic women.[ncbi.nlm.nih.gov] Overexpression of microRNA‑148a significantly reduced estrogen receptor a (ERα) protein expression and suppressed phosphoinositide‑3kinase regulatory subunit 1 (PI3K) and[ncbi.nlm.nih.gov] RESULTS: In all 4patients, teriparatide was effective in halting the fracture cascade, including in the 2patients who remained on long-term glucocorticoid therapy.[ncbi.nlm.nih.gov] kinase catalytic subunit type 3 [ 36 ] Other pathways ALDH7A1 Aldehyde dehydrogenase 7 family, member A1 [ 33 ] ARHGAP1 Rho GTPase activating protein 1 [ 26 , 32 ] COL1A1[doi.org] Calcium fluxes are also important mediators of hormonal effects on target organs through several intracellular signalling pathways, such as the phosphoinositide and cyclic[fao.org]

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  • Malignant Neoplasm

    Received: 28 October 2014 / Revised: 5 February 2015 / Accepted: 11 February 2015 / Published: 27 February 2015 Background: Intestinal exposure to gliadin leads to zonulin upregulation[dx.doi.org] ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer. 2003 Mar;3(3):155-68. Review.[ghr.nlm.nih.gov] Fig. 1 Colorectal cancer (CRC) progression as a model for epigenetic alteration cascade and prevention strategies.[doi.org] AMPK: AMP-dependent kinase; IGF: insulin-like growth factor; LKB1: Serine/threonine-protein kinase 11; mTOR: mammalian target of rapamycin; PI3K: phosphoinositide 3-kinase[doi.org] HMGA1b protein interferes with estrogen-induced upregulation of BRCA1 .[doi.org]

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  • Acromegaly

    Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR, 1994 Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis[doi.org] GH is part of a cascade of hormones that, as the name implies, regulates the physical growth of the body.[endocrine.niddk.nih.gov] The aryl hydrocarbon receptor ( AhR ) pathway is also implicated in leukemogenesis, where, for example, primary human T-cell leukemia cells exhibit upregulated AhR expression[karger.com] This cascade begins in a part of the brain called the hypothalamus, which makes hormones that regulate the pituitary.[pituitary.mgh.harvard.edu] kinase (PI3K) [12] .[diapedia.org]

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  • Influenza

    No significant upregulation was observed in either group of guinea pigs for TNFα, TBK1, IRF5, or IFNγ ( Figure 5 ).[doi.org] Sci Rep 2013; 3 :1106. [ PubMed ] 152. Pascua PN, Lee JH, Song MS, Park SJ, Baek YH, Ann BH, Shin EY, Kim EG, Choi YK.[ncbi.nlm.nih.gov] Most cells have intracellular sensors of viral products that, when activated, initiate a signaling cascade that results in transcriptional induction of the IFNβ gene.[doi.org] Rhinovirus triggers an inflammatory cascade, evidenced by the presence of inflammatory mediators (e.g., IL-8) and proinflammatory cytokines (e.g., kinins) in nasal secretions[dx.doi.org] Mx1, TLR3, MDA-5, IRF7, STAT1, RANTES, MCP1, MCP3, and IL-1β were found to be upregulated in response to infection in animals housed under both conditions ( Figure 5 ).[doi.org]

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  • T-cell Acute Lymphoblastic Leukemia

    Casein kinase 2 inhibition further abrogated interleukin-7-mediated cell growth and upregulation of the transferrin receptor, and blocked cyclin A and E upregulation and cell[ncbi.nlm.nih.gov] Kinases Class Ib Phosphatidylinositol 3-Kinase PIK3CD protein, human PIK3CG protein, human Grant support S10 OD012351/OD/NIH HHS/United States R01 CA169162/CA/NCI NIH HHS[ncbi.nlm.nih.gov] […] cell development, the transcriptional program is strictly regulated in a lineage- and stage-specific manner that requires a number of transcription factors to work in a cascade[ncbi.nlm.nih.gov] Abstract Selective phosphoinositide 3-kinase (PI3K)/AKT/mTOR inhibitors are currently under evaluation in clinical studies.[ncbi.nlm.nih.gov] Therefore, specific targeting of these signaling cascades could provide a unique opportunity to overcome glucocorticoid resistance in human T-ALL.[journals.plos.org]

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  • Dementia

    […] gmail.com Search for more papers by this author First published: 28 April 2016 Cited by: 15 Abstract Objective Rosacea is a common chronic inflammatory skin disorder where upregulation[doi.org] […] disease type C, pantothenate kinase-associated neurodegeneration, Tay–Sachs disease, and Wilson's disease (all recessive).[en.wikipedia.org] An optimal disease-modifying strategy should interfere with this cascade either by interfering with an upstream causal event (thought by many to be generation of Aβ) or targeting[doi.org] Statins thereby reduce the formation and entry of LDL‐C into the circulation and upregulate LDL receptor activity, lowering LDL‐C and triglycerides and increasing HDL‐C.[doi.org] The activated complement cascade following spirochete infections ( 11 Miklossy J .[doi.org]

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  • Familial Acne Inversa

    Analyses of IL-1β-induced transcriptome in various cell types disclosed an overlap of upregulated molecules causing immune cell infiltration and extracellular matrix degradation[readbyqxmd.com] Furthermore, a remarkable elevation of expression of phosphoinositide 3-kinase (PI3K), AKT and its activated form pAKT was illustrated in siRNA-treated HaCaT cells.[acnecurealliance.org] The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and[genecards.org] However, this study observed significant upregulation of integrins α6 and β4 (signaling molecules with adhesive properties) within the sebaceous gland of HS patients compared[f1000research.com] Furthermore, a remarkable elevation of expression of phosphoinositide 3-kinase (PI3K), AKT and its activated form pAKT was illustrated in siRNA-treated HaCaT cells.[acnecurealliance.org]

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  • Porphyromonas Gingivalis

    Insertion of IS1598 into the nrdD-like gene promoter region may be related to the phenotypic differences in virulence among P. gingivalis strains through upregulation of the[ncbi.nlm.nih.gov] CD14 plays an important role in this "inside-out" proadhesive pathway by binding fimbriae and facilitating the activation of TLR2 and phosphatidylinositol 3-kinase signaling[ncbi.nlm.nih.gov] The aim of this study was to investigate the activation of signaling cascades in primary epithelial cells and oral cancer cell lines by a profiler PCR array.[ncbi.nlm.nih.gov] MβCD (10 mM; lipid raft disrupting agent) and wortmannin (100 nM; phosphoinositide-3-kinase inhibitor) were also used.[doi.org] Among the genes highly upregulated by the nonencapsulated PgC strain were ones coding for cytokines and chemokines.[ncbi.nlm.nih.gov]

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  • Infectious Mononucleosis

    The addition of free gp350 to primary B cells leads to CD19 tyrosine phosphorylation and the subsequent recruitment of the phosphatidylinositol 3-kinase ( 41 ).[dx.doi.org] Goodin DS (2009) The causal cascade to multiple sclerosis: a model for MS pathogenesis. PLoS ONE 4: e4565. View Article Google Scholar 9.[doi.org] The genes also grouped into 2 major groups; one that contained most of the mitochondrial function genes that were upregulated in cases and the other contained cell cycle checkpoints[dx.doi.org] […] immediate early (IE) genes that are transcription factors but also targets of the virus-specific CTL response (CTL IEs ). 16 The immediate early transcription factors turn on a cascade[doi.org] Heterophile tests use various mammalian erythrocytes to detect IgM class antibodies, which are present during the generalized immune upregulation that characterizes acute[doi.org]

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