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1,006 Possible Causes for 3C, proteases

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  • Hereditary Pancreatitis

    […] associated with exocrine pancreatic insufficiency leading to maldigestion and/or pancreatic endocrine insufficiency (glucose intolerance progressing to diabetes mellitus type 3c[orpha.net] The affected genes have been identified as the cationic trypsinogen (CT) gene and the serine protease inhibitor Kazal type 1 (SPINK1) gene.[ncbi.nlm.nih.gov] Using information from the human genome project, the hereditary pancreatitis gene was identified as the cationic trypsinogen gene (protease serine 1, PRSS1).[ncbi.nlm.nih.gov]

  • Coxsackievirus Infection

    Overexpression of viral protease 2A reproduced CVB3-induced cytoplasmic redistribution of AUF1, while in vitro cleavage assay revealed that viral protease 3C contributed to[ncbi.nlm.nih.gov] In an effort to discover how cells detect viral infections, we found that the viral protease 3C(pro) cleaves IkappaBalpha.[ncbi.nlm.nih.gov] الصفحة 214 - Enteroviral protease 2A cleaves dystrophin: Evidence of cytoskeletal disruption in an acquired cardiomyopathy. Nat. Med., 5, 320—326. ‏[books.google.com]

  • Streptococcus Pyogenes

    Using our isogenic mutants, we found that the WT GAS parental strain and the Δ scpA mutant each efficiently degraded KC and MIP‐2 ( Figure 3C and D ).[doi.org] Maturation serine proteases 2018 The Author(s) This is an Accepted Manuscript; not the final Version of Record.[biochemj.org] SpeB is a 28 kDa extracellular protease and surface associated molecule produced by most GAS strains.[bmcmicrobiol.biomedcentral.com]

  • Vaginitis

    […] diagnosis accuracy both decreased with increasing prevalence, whereas the investigational test accuracy remained relatively high and constant over increasing prevalence ( Fig. 3C[jcm.asm.org] […] of these bacteria to invade in the setting of BV is probably potentiated by the production of several molecules through bacterial metabolism, including sialidase 106 and protease[glowm.com]

  • Chronic Pancreatitis

    Distinguishing type 3c diabetes from other types It is not always easy to diagnose and classify a patient with type 3c diabetes mellitus correctly.[doi.org] […] serine 1 (PRSS1), serine protease inhibitor, Kazal type 1 (SPINK1), cystic fibrosis transmembrane conductance regulator gene (CFTR), chymotrypsin C (CTRC), calcium-sensing[ncbi.nlm.nih.gov] Genetic studies indicate the importance of mutations in the serine protease inhibitor, Kazal type 1 gene (SPINK1) in the pathogenesis of CP This report describes a case of[ncbi.nlm.nih.gov]

  • Staphylococcal Scalded Skin Syndrome

    An exfoliating toxin-releasing Staphylococcus aureus, phage type II type 3C, was isolated from the sputum and from blood cultures.[ncbi.nlm.nih.gov] SPINK5 encodes lymphoepithelial Kazal-type-related inhibitor (LEKTI), a new type of serine protease inhibitor involved in the regulation of skin barrier formation and immunity[ncbi.nlm.nih.gov] Abstract Staphylococcal scalded skin syndrome is a toxin mediated Staphylococcal infection, the toxin produced by staphylococcus aureus type 2 phage types (55,71,3A,3B,3C)[ncbi.nlm.nih.gov]

  • Prion Disease

    All LTβR / mice succumbed to scrapie ( LTβR / : n   4, 272 0 dpi) and displayed PrP deposits in their brains ( Fig. 3C ).[doi.org] Abstract Protease-resistant prion protein (PrP(Sc) ) is diagnostic of prion disease, yet its detection is frequently difficult.[ncbi.nlm.nih.gov] Western blot analysis revealed a protease-resistant prion protein fragment (PrP7-8), the molecular hallmark of Gerstmann-Straussler-Scheinker disease.[ncbi.nlm.nih.gov]

  • Pyknodysostosis

    Handwrist radiograph showed acro-osteolysis of terminal phalanges ( Fig. 3C ).[synapse.koreamed.org] Thus, pycnodysostosis results from gene defects in a lysosomal protease with highest expression in osteoclasts.[ncbi.nlm.nih.gov] Pyknodysostosis is a rare autosomal recessive osteosclerosing skeletal disorder caused by mutations in the CTSK gene situated at 1q21 that codes for cathepsin K - a lysosomal cysteine protease[ncbi.nlm.nih.gov]

  • Astrovirus

    All genotyped samples belonged to lineage HAstV-3c, which could be presently emerging.[ncbi.nlm.nih.gov] […] the genetic distance, number of synonymous mutations per synonymous site (dS), number of non-synonymous mutations per non-synonymous site (dN) and the dN/dS ratio in the protease[ncbi.nlm.nih.gov] Human astrovirus-BF34 was most closely related to mamastrovirus species 8 and 9 also found in human with which it shared 62%, 74%, and 57% amino acid identities over its protease[ncbi.nlm.nih.gov]

  • Atopic Dermatitis

    Exposure of the K14-CPD-PL mouse skin to UV revealed several PR-dependent, and thus CPD-provoked biological processes (Fig. 3C ).[doi.org] S. aureus penetration through the epidermis was dependent on bacterial viability and protease activity, because killed bacteria and a protease-null mutant strain of S. aureus[ncbi.nlm.nih.gov] Abstract Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a large multidomain serine protease inhibitor that is expressed in epidermal keratinocytes.[ncbi.nlm.nih.gov]

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