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43 Possible Causes for 3beta hydroxy, dehydrogenase, steroid

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  • Digitalis

    Abstract During the biosynthesis of cardiac glycosides, Delta (5)-3beta-hydroxysteroid dehydrogenase (3 beta HSD, EC 1.1.1.51) converts pregnenolone (5-pregnen-3beta-ol-20[ncbi.nlm.nih.gov] Abstract Digitalis-like compounds (DLC) are a family of steroid hormones synthesized in and released from the adrenal gland.[ncbi.nlm.nih.gov] […] group and a 3beta-hydroxy group, the latter usually linked to one or more sugar rings.[ncbi.nlm.nih.gov]

  • Momordica Charantia

    11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the intracellular regeneration of active cortisol from inert cortisone in key metabolic tissues, thus regulating[ncbi.nlm.nih.gov] 2), and 3beta-hydroxy-23(R)-methoxycucurbita-6,24-dien-5beta,19-olide (3), were isolated from the fruit pulp of Momordica charantia.[ncbi.nlm.nih.gov] Phytochemicals including proteins, polysaccharides, flavonoids, triterpenes, saponins, ascorbic acid and steroids have been found in this plant.[ncbi.nlm.nih.gov]

  • Dehydroepiandrosterone

    Additionally, supplementation with DHEA in PORs decreased DNA damage and apoptosis in CCs while enhancing the mitochondrial mass, mitochondrial dehydrogenase activity and[ncbi.nlm.nih.gov] CAS 53-43-0 Deca Durabolin Steroids Dehydroisoandrosterone / DHEA / 3Beta-Hydroxy-5-Androsten-17-One Detailed Product Description: Deca Durabolin Steroids Dehydroisoandrosterone[globalsources.com] , and 4) steroid secretion studies in vitro of the tumor tissue, surrounding tissue, and contralateral ovarian tissue.[ncbi.nlm.nih.gov]

  • Alkylating Agent

    The mitochondrial membrane potential (ΔΨ(m)), O(2) consumption and dehydrogenase activities were rapidly dissipated/or inhibited by 3-BrPA in respiration medium containing[ncbi.nlm.nih.gov] ASE, namely 3beta-hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam-p-bis(2-chloro-ethyl)amino phenylacetate (AzaSteroidalEster, NSC-71964), is an alkylating[ncbi.nlm.nih.gov] Abstract Growth velocity measurements were assessed in 12 children with steroid responsive but frequent relapsing or dependent nephrotic syndrome prior to and following treatment[pediatrics.aappublications.org]

  • Niemann-Pick Disease Type C

    […] spheroids contained masses of degenerated organelles and neurofilaments in various proportions and displayed variable activities of acid phosphatase, nonspecific esterase and dehydrogenases[ncbi.nlm.nih.gov] These acids were shown to have a 3beta-hydroxy-Delta(5) structure and to carry an oxo or hydroxy group at C-7.[ncbi.nlm.nih.gov] It is also the basic building block of steroid hormones , including neurosteroids .[en.wikipedia.org]

  • 3Beta-Hydroxy-Delta5-C27-Steroid Oxidoreductase Deficiency

    Other names in common use include: progesterone reductase Δ 5 -3β-hydroxysteroid dehydrogenase 3β-hydroxy-5-ene steroid dehydrogenase 3β-hydroxy steroid dehydrogenase/isomerase[en.wikipedia.org] 3beta-hydroxy-delta5-c27-steroid oxidoreductase deficiency (3β-HSD) is an uncommon autosomal recessive disorder, characterized by defects in the synthesis of bile acids.[symptoma.com] HSD3B7 encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily[cloud-clone.com]

  • 2-Methylbutyryl-CoA Dehydrogenase Deficiency

    2-methylbutyryl-CoA dehydrogenase deficiency is an autosomal recessive disease characterized by an impairment in the degradation of isoleucine.[symptoma.com] Cheng JB, Jacquemin E, Gerhardt M, et al: Molecular genetics of 3beta-hydroxy-delta5-C27 steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis[karger.com] Mitochondrial Fatty Acid Oxidation 309 Disorders of Carbohydrate and Glycogen Metabolism 335 Disorders of Glucose Transport 357 Genetic Dyslipoproteinemias 537 Disorders of Steroid[books.google.de]

  • Combretum

    Compounds 1 and 5 also showed very strong inhibition of 3alpha-hydroxysteroid dehydrogenase with an IC(50) of 0.3 microg/ml.[ncbi.nlm.nih.gov] Brown ring at the boundary of mixture shows the presence of steroids. (N.B. Test tube was kept in ice as exo thermic reaction occurs.)[ijddr.in] In addition to four known triterpenoids, 1alpha,3beta-dihydroxy-12-oleanen-29-oic (1), 1-hydroxy-12-olean-30-oic acid (2), 3,30-dihydroxyl-12-oleanen-22-one (3), and 1,3,24[ncbi.nlm.nih.gov]

  • Congenital Bile Acid Synthesis Defect Type 2

    A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal[lpi.oregonstate.edu] In detail, the following congenital bile acid synthesis defects are distinguished: Congenital bile acid synthesis defect type 1 or 3beta-hydroxy-delta5-C27-steroid oxidoreductase[symptoma.com] This hypothesis is based on abnormalities of urinary steroid profiles that have been observed in CBAS2 patients.[symptoma.com]

  • Bacillus Megaterium

    We have placed gdhA (encoding glucose dehydrogenase) from B. megaterium, lacZ (encoding beta-galactosidase) from E. coli, mro (encoding mutarotase) from Acinetobacter calcoaceticus[ncbi.nlm.nih.gov] -20(29)-en-28-oic acid, 1beta-hydroxy-3-oxo-lup-20(29)-en-28-oic acid, and 3beta,7beta, 15alpha-trihydroxy-lup-20(29)-en-28-oic acid based on nuclear magnetic resonance and[ncbi.nlm.nih.gov] Recently, it was shown that besides 3-oxo- 4-steroids, 3-hydroxy- 5-steroids as well as di- and triterpenes can also serve as substrates for this biocatalyst.[ncbi.nlm.nih.gov]