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1,063 Possible Causes for 4, Aldehyde, DEHYDROGENASE

  • Aldehyde

    Li W 1 , Zhou H 2 , Chu Y 3 , Wang X 3 , Luo R 3 , Yang L 3 , Polachi N 3 , Li X 3 , Chen M 4 , Huang L 5 , Yan X 6 , Guo Z 3 , Sun H 7 .[ncbi.nlm.nih.gov] Some aldehydes are substrates for aldehyde dehydrogenase enzymes which metabolize aldehydes in the body.[en.wikipedia.org] These enzymes include alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which play a significant role in the metabolism of many biological substances and exist[ncbi.nlm.nih.gov]

  • Sjogren-Larsson Syndrome

    Furthermore, as might be predicted from the essential role of FALDH in leucotriene B(4) (LTB(4)) metabolism, elevated urinary concentrations of LTB(4) and 20-OH-LTB(4) were[ncbi.nlm.nih.gov] Toxicity of long-chain aldehydes for FALDH-deficient cells decreased almost to the level of unaffected keratinocytes.[ncbi.nlm.nih.gov] Studies of mutations in SLS should prove useful for understanding structure-function correlations in FALDH and other aldehyde dehydrogenase proteins.[ncbi.nlm.nih.gov]

  • Xanthinuria

    In order to study the purine metabolism in the hypouricemic condition of this disorder, a single oral dose of allopurinol (4-hydroxypyrazolo[3,4-d]pyrimidine) was administered[ncbi.nlm.nih.gov] […] lack aldehyde oxidase activity.[emedicine.com] The duodenal mucosa from the subject had no xanthine dehydrogenase protein while the mRNA level was not reduced.[doi.org]

  • Disulfiram

    Huang J 1, 2 , Campian JL 3, 4 , Gujar AD 5 , Tran DD 6, 3, 4 , Lockhart AC 3, 4 , DeWees TA 6 , Tsien CI 6, 3 , Kim AH 3, 5 .[ncbi.nlm.nih.gov] Disulfiram (DSF), an inhibitor of aldehyde dehydrogenase, is currently in clinical use for treating alcoholism.[ncbi.nlm.nih.gov] Through inhibition of aldehyde dehydrogenase, disulfiram heightens serum aldehyde concentration after alcohol ingestion and causes aversive disulfiram-ethanol reaction.[ncbi.nlm.nih.gov]

  • Influenza

    Older: 0/1/2/3 127/66/23/1 134/63/15/1 0.59 4 Younger: 0/1/2/3/4 109/75/29/4/0 108/75/25/4/1 0.87 4 Starting age of nursery school [ n (%)] 0.21 4 6 (35) 61 (29) 3 y 138[ajcn.org] Infectivity of the virion is easily inactivated by all alcoholic disinfectants, chlorine, aldehydes and temperature above 70 C. Sources www.gov.uk/...[news-medical.net] […] lymphopenia, elevated amino-transaminases, thrombocytopenia, prolonged prothrombin time and activated partial thromboplastin time, increased D-Dimer, increased serum lactate dehydrogenase[ncbi.nlm.nih.gov]

  • Xanthinuria Type 1

    Diseases testing done with next gene sequencing NGS sample type Blood or DNA and reporing time is 4 to 5 weeks How to get tested Works Follow below step by step process to[dnalabsuae.com] […] allopurinol to oxipurinol during an allopurinol loading test for determining the type of classical xanthinuria revealed that the patients had classical type 1 xanthinuria, because aldehyde[ncbi.nlm.nih.gov] Proteolytic conversion of xanthine dehydrogenase from the NAD-dependent type to the O2-dependent type.[link.springer.com]

  • Xanthinuria Type 2

    Showing of 4 5%-29% of people have these symptoms Nephrolithiasis Kidney stones 0000787 Renal insufficiency Renal failure Renal failure in adulthood [ more ] 0000083 Percent[rarediseases.info.nih.gov] Also Known As Xanthine dehydrogenase and xanthine aldehyde oxydase dual deficiency[codelay.com] […] of xanthine dehydrogenase and aldehyde oxidase.[malacards.org]

  • Disulfiram-like Reaction

    Indian J Pharmacol. 2013 Jul-Aug;45(4):399-400. doi: 10.4103/0253-7613.114991.[ncbi.nlm.nih.gov] The protein expression of aldehyde dehydrogenase 2 was not affected at all.[ncbi.nlm.nih.gov] J Postgrad Med. 2009 Oct-Dec;55(4):292-3. doi: 10.4103/0022-3859.58940.[ncbi.nlm.nih.gov]

  • Osteoporosis

    Figures and Tables - Analysis 4.2 Comparison 4 Musculoskeletal pain, Outcome 2 Lower limb pain 4 years.[doi.org] IFNA8, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21 , Interferon α proteins [ 36 ] PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3 [ 36 ] Other pathways ALDH7A1 Aldehyde[doi.org] Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3β-hydroxy-steroid dehydrogenase . J Biol Chem 2001 ; 276: 16767 – 71 .[doi.org]

  • Deficiency of Sulfite Oxidase

    Mutation analysis of the sulfite oxidase gene revealed that the patient was homozygous for a novel 4-base pair deletion, and both of his parents were found to be heterozygous[ncbi.nlm.nih.gov] The cofactor is essential for the function of the human enzymes sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase.[ommbid.mhmedical.com] Abstract A patient suffering from a combined deficiency of sulfite oxidase (sulfite dehydrogenase; sulfite:ferricytochrome c oxidoreductase, EC 1.8.2.1) and xanthine dehydrogenase[ncbi.nlm.nih.gov]

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