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10,957 Possible Causes for 4, E2F, factor, human, protein,, transcription

Did you mean: 4, E2F, factor, human, proteus, transcription

  • LIG4 Syndrome

    Abstract DNA ligase 4 deficiency (LIG4-SCID) causes lymphopenia (T-B-NK ) and a radiosensitive SCID (RS-SCID) phenotype.[bloodadvances.org] Alternatively spliced transcript variants encoding the same protein have been observed.[okdb.appliedbioinfo.net] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[mcb.asm.org] Osteosarcoma E2F-1 and a cyclin-like DNA repair enzyme, uracil-DNA glycosylase, provide evidence for an autoregulatory mechanism for transcription.[brenda-enzymes.org] However, one of the more important risk factors established to OC is family history.[wjgnet.com] PAGES GENES INVOLVED Human Gene Zebrafish Ortholog OMIM Term OMIM Phenotype ID LIG4 lig4 LIG4 syndrome 606593 ZEBRAFISH MODELS No data available PHENOTYPE No data available[zfin.org]

  • T-cell Acute Lymphoblastic Leukemia

    This frees E2F to activate genes involved in the S-phase entry and DNA replication.[clincancerres.aacrjournals.org] Our experiments confirm that plumbagin induces a caspase-dependent apoptosis of MOLT-4 cells, with no significant cytotoxicity seen for normal peripheral blood mononuclear[ncbi.nlm.nih.gov] In hematopoietic cell development, the transcriptional program is strictly regulated in a lineage- and stage-specific manner that requires a number of transcription factors[ncbi.nlm.nih.gov] * Neoplasm Proteins/biosynthesis Neoplasm Proteins/genetics Nuclear Proteins/antagonists & inhibitors Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy* Protein[ncbi.nlm.nih.gov] KEYWORDS: ABT-737; Box-Behnken design and response surface methodology; IRAK1/4 inhibitor; PEG-PLGA; T cell acute lymphoblastic leukemia[ncbi.nlm.nih.gov] Their exceptional physicochemical properties, possibility of humanization, and unique antigen recognition properties make them excellent candidates for targeted delivery of[ncbi.nlm.nih.gov]

  • Human Herpesvirus 8

    Grigolato, Jessica (2013) ACTIVATING TRANSCRIPTION FACTOR 4 (ATF4) IS UPREGULATED BY HUMAN HERPESVIRUS 8 INFECTION, INCREASES VIRUS REPLICATION AND PROMOTES VIRUS PROANGIOGENIC[eprints.unife.it] […] for newly annotated transcripts.[doi.org] […] response signaling in addition to enhancing viral protein folding.[ncbi.nlm.nih.gov] The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat.[doi.org] Geographic location, ethnicity, age and HIV-1 infection are risk factors.[ncbi.nlm.nih.gov] In 1994, Chang and Moore reported on the latest of the gammaherpesviruses to infect humans, human herpesvirus 8 (HHV-8).[ncbi.nlm.nih.gov]

  • Influenza

    Older: 0/1/2/3 127/66/23/1 134/63/15/1 0.59 4 Younger: 0/1/2/3/4 109/75/29/4/0 108/75/25/4/1 0.87 4 Starting age of nursery school [ n (%)] 0.21 4 6 (35) 61 (29) 3 y 138[ajcn.org] Activated IRF3, together with NF-κB and AP-1, accumulate in the nucleus, bind to the IFNβ promoter, and stimulate transcription.[doi.org] This study aimed to estimate the proportion of chronically ill adults vaccinated against influenza in consecutive seasons and to identify associated factors.[ncbi.nlm.nih.gov] The rapid evolution of influenza A and B viruses contributes to annual influenza epidemics in humans.[ncbi.nlm.nih.gov] Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40 , 627–633 (1985). 5. Zebedee, S.L. & Lamb, R.A.[dx.doi.org] We aimed to assess risk factors associated with influenza-associated severe acute respiratory illness (SARI) hospitalisation in South Africa.[ncbi.nlm.nih.gov]

    Missing: E2F
  • Hepatitis B Virus

    An adenovirus early region 4 gene product is required for induction of the infection-specific form of cellular E2F activity. Genes Dev. 3 : 1062 -1074. Haviv, I., D.[doi.org] J Infect Chemother. 2015 Apr;21(4):302-4. doi: 10.1016/j.jiac.2014.10.015. Epub 2014 Nov 11.[ncbi.nlm.nih.gov] HBx is recruited to viral and cellular promoters and activates transcription by interacting with transcription factors and coactivators.[ncbi.nlm.nih.gov] This study is aimed to determining seroprevalence of hepatitis B virus infection and associated factors among healthcare workers in northern Tanzania.[ncbi.nlm.nih.gov] , and tested the hypothesis of HBV-human co-divergence.[ncbi.nlm.nih.gov] Confocal microscopy also revealed that HBx protein could co-localize with full-length Orail protein in HEK293 cells.[ncbi.nlm.nih.gov]

  • Werner Syndrome

    Kamiya H 1, 2, 3, 4 , Yamazaki D 1 , Nakamura E 2 , Makino T 2, 4 , Kobayashi M 3 , Matsuoka I 3 , Harashima H 1 .[ncbi.nlm.nih.gov] Our findings indicate that mutations can also lead to markedly decreased WRN transcript stability.[ncbi.nlm.nih.gov] Here we report that the WS protein does indeed catalyze DNA unwinding.[ncbi.nlm.nih.gov] Transcription factor Dp-2 ( TFDP2 ) is a component of the drtf1/e2f transcription factor complex and regulates genes encoding proteins required for the progression of S-phase[doi.org] Abstract XRCC4-like factor (XLF) is involved in non-homologous end joining-mediated repair of DNA double-strand breaks (DSBs).[ncbi.nlm.nih.gov] To examine the expression and distribution of WRN proteins in the retinas, immunohistochemistry for WRN proteins was performed in human retinas.[ncbi.nlm.nih.gov]

  • Ewing Family of Tumors

    Transfection of E2F-decoy oligonucleotides into EFT cells markedly inhibited the growth of the cells ( 30 ).[dx.doi.org] We studied the expression of 4 tumor suppressor proteins in the Ewing family of tumors (EFTs).[ncbi.nlm.nih.gov] RESULTS: In-frame hybrid transcripts were observed in 89 cases.[ncbi.nlm.nih.gov] Significant prognostic factors for OS were age, performance status, and metastases at the time of diagnosis (P 0.01, respectively).[ncbi.nlm.nih.gov] […] gene by substituting a sequence encoding a putative RNA-binding domain for that of the DNA-binding domain of the human homologue of murine Fli-1 .[doi.org] […] also changes the epigenetic state of gene regulatory elements, such as promoters and putative enhancers, possibly in cooperation with cofactors such as transcription factor E2F[nature.com]

  • Adenovirus

    -1 factor and enhancing the E2F-dependent transcription for cell cycle progression.[ncbi.nlm.nih.gov] Human adenovirus type 4 (HAdV-4) is an epidemic virus that contributes to serious acute respiratory disease (ARD) in both pediatric and adult patients.[ncbi.nlm.nih.gov] How histone acetylation promotes transcription is not clearly understood.[ncbi.nlm.nih.gov] Abstract It has been proposed that blood coagulation factors, principally factor X (FX), enhance the uptake of human adenovirus type 5 (Ad5) into cultured epithelial cells[ncbi.nlm.nih.gov] […] complications Adenovirus Infections, Human/virology* Adenoviruses, Human/genetics* Adenoviruses, Human/physiology* Adolescent Adult Antigens, Viral, Tumor/genetics BK Virus[ncbi.nlm.nih.gov] KEYWORDS: 22K; 33K; 52K; BAdV-3; NLS; Protein- protein interaction[ncbi.nlm.nih.gov]

  • Primary Effusion Lymphoma

    The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells .[ncbi.nlm.nih.gov] Virology. 2014 Jun;458-459:4-10. doi: 10.1016/j.virol.2014.04.020. Epub 2014 May 5.[ncbi.nlm.nih.gov] Collectively, our results demonstrate that the inhibitory effect of triptolide on hTERT transcription is possibly mediated by inhibition of transcription factor Sp1 in PEL[ncbi.nlm.nih.gov] 8) in conjunction with human immunodeficiency virus (HIV) infection.[ncbi.nlm.nih.gov] The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma–E2F pathway and with the oncogene Hras transforms primary rat cells .[dx.doi.org] To elucidate the factors associated with a good prognosis, this study analyzed the clinical parameters of four patients treated in the department and 109 patients reported[ncbi.nlm.nih.gov]

  • Vitamin K

    […] independently of p53 [ 116 ]. p21 inhibits cell cycle progression through the inhibition of CDK-2 activity, which is important for the phosphorylation of Rb and activation of E2F[dx.doi.org] Despite this great difference, the origin of tissue menaquinone-4 has yet to be exclusively defined.[ncbi.nlm.nih.gov] We previously demonstrated that vitamin K2 is a transcriptional regulator of bone marker genes in osteoblastic cells and that it may potentiate bone formation by activating[ncbi.nlm.nih.gov] He had a normal factor V level; however, factors VII and X were less than 1% and factors II and IX were between 2% and 4% of normal.[ncbi.nlm.nih.gov] […] subclinical vitamin K deficiency was induced in 32 healthy subjects (four groups of eight males and females) aged 20-40 and 60-80 yr residing in the Metabolic Research Unit of the Human[ncbi.nlm.nih.gov] Approximately 60% of protein S in human plasma is bound to the complement regulatory protein C4b-binding protein (C4BP) in a high-affinity, high-molecular-weight complex.[ncbi.nlm.nih.gov]