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534 Possible Causes for 4, Kinase, MEK

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  • Carbachol

    MEK/ERK/RSK pathway plays a critical role in p70S6K1 activation in GPCR-stimulated T84 cells.[ncbi.nlm.nih.gov] In other experiments, 5 min of IL-4 did not immediately decrease transients but did after a 25-min delay. Goat antihuman IL-4 antibody abolished the effect of IL-4.[ncbi.nlm.nih.gov] […] to protein kinase C (PKC) zeta, and by the p70S6K inhibitor rapamycin.[ncbi.nlm.nih.gov]

  • Lyme Disease

    Due to the vasculitis, immunosuppression with azathioprine and topical cyclosporine were given for 4 months. Since then she has been free of flare-ups.[ncbi.nlm.nih.gov] METHODS: In this study, we explored the role of several TLR and EGFR/FGFR/PDGFR tyrosine kinase pathways in inducing inflammation in the presence of B. burgdorferi, using[ncbi.nlm.nih.gov] The c-di-GMP network of Borrelia burgdorferi, a causative agent of Lyme disease, consists of Rrp1, a diguanylate cyclase/response regulator; Hpk1, a histidine kinase; PdeA[ncbi.nlm.nih.gov]

  • Indomethacin

    Pretreatment with the p38 MAPK inhibitor significantly attenuated the disruption of barrier function, but JNK and MEK/ERK inhibition had no effect.[ncbi.nlm.nih.gov] Indomethacin Ester, 4-Methoxyphenyl- is a cell-permeable 4-methoxyphenyl ester derivative of the non-steroidal anti-inflammatory drug (NSAID).[scbt.com] We investigated the role of the intracellular energy-sensing AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway in the in vitro antiglioma effect[ncbi.nlm.nih.gov]

  • Glomerulonephritis

    The renin–angiotensin system may be subsequently activated, because of the decrease in perfusion of juxtaglomerular apparatus , which may result in hypertension. [4] : 554[en.wikipedia.org] Activation of spleen tyrosine kinase (SYK), Bruton's tyrosine kinase (BTK), platelet-derived growth factor receptor (PDGFR), epidermal growth factor receptor (EGFR) and discoidin[ncbi.nlm.nih.gov] Treatment started in November 2015, with Encorafenib and Binimetinib, new BRAF and MEK inhibitors, respectively.[ncbi.nlm.nih.gov]

  • Ocular Albinism

    Stimulation of the RAS/RAF/mitogen activated protein kinase kinase (MEK)/extracellular signal‑regulated kinase (ERK) pathway using growth factors enhanced OA1 expression and[ncbi.nlm.nih.gov] Khan KN 1, 2, 3 , Lord EC 3 , Arno G 3 , Islam F 2 , Carss KJ 4, 5 , Raymond F 4, 6 , Toomes C 3 , Ali M 3 , Inglehearn CF 3 , Webster AR 1, 2 , Moore AT 1, 2, 7 , Poulter[ncbi.nlm.nih.gov] Other clinical findings in the complex glycerol kinase deficiency (CGKD) patients are mental retardation, short stature, and hypogonadotropic hypogonadism.[ncbi.nlm.nih.gov]

  • Granulosa Cell Tumor

    A tumor-tissue microarray was immunohistochemically stained for HER2-4 and GATA4.[ncbi.nlm.nih.gov] […] report a case of a 60-year-old woman with a heavily pretreated recurrent, c-kit positive, GCT of the ovary who underwent an experimental therapy with imatinib, a tyrosine kinase[ncbi.nlm.nih.gov] TGFα also rapidly activated the EGFR/MEK/ERK pathway, and P38 MAPK pathways, as indicated by the rapid phosphorylation of EGFR, MEK, ERK1/2, P38, and CREB after TGFα treatment[ncbi.nlm.nih.gov]

  • Opioid Withdrawal

    Data collected included: opioid withdrawal score (WAT-1), opioid taper rate (total dose of opioid per day in morphine equivalents per kilogram [MEK]), pretaper peak MEK, pretaper[ncbi.nlm.nih.gov] The 4-week taper group also reported significantly fewer disruptions in sleep compared to the other experimental groups.[ncbi.nlm.nih.gov] In contrast, opioid withdrawal following chronic activation of MOR uncovers AC superactivation and subsequent increases in cAMP and protein kinase A (PKA) activity.[ncbi.nlm.nih.gov]

  • Polyploidy

    Abstract Polo-like kinase 4 (PLK4) is a serine/threonine kinase regulating centriole duplication.[ncbi.nlm.nih.gov] Many small-molecule inhibitors of Aurora kinases are currently undergoing clinical trials. Aurora A kinase is essential for successful mitotic transition.[ncbi.nlm.nih.gov] […] this study, we show how Ras activation causes aberrant nuclear localization of phosphorylated mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK; MEK[ncbi.nlm.nih.gov]

  • Anemarrhena

    Taken together, these results indicate that mangiferin exerts anti-photoaging activity in UVB-irradiated hairless mice by regulating MMP-9 expression through inhibition of MEK[ncbi.nlm.nih.gov] Zhi Mu, Anemarrhena (Anemarrhena Asphodeloides) Glycerite, Dried Root Powder Alcohol-Free Liquid Extract, 知母, Glycerite Herbal Supplement 4 oz Average rating: 0 out of 5 stars[walmart.com] […] cells with advanced glycation end products (AGEs) to establish the model of endothelial dysfunction in vitro and observed the effect of TPAA (10, 30, or 100 μg/mL) on AMP-Kinase[ncbi.nlm.nih.gov]

  • Esophagitis

    CDX, Caudal-related homeobox; ERK, extracellular-signal-regulated kinase; GORD, gastro-oesophageal reflux disease; IL, interleukin; MAPK, mitogen-activated protein kinase; MEK[biochemsoctrans.org] The primary efficacy outcome was the endoscopic healing rates at 4 and 8 weeks. Heartburn relief rates were a secondary efficacy outcome.[ncbi.nlm.nih.gov] NF-κB-inducing kinase (NIK; MAP3K14) is a key signaling molecule of the noncanonical NF-κB (NFKB1) pathway, an alternative signaling cascade producing chemokines involved[ncbi.nlm.nih.gov]