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9,748 Possible Causes for 4, bone, morphogenetic, protein

Did you mean: 4, bone, morphogenetic, proteus

  • Osteoporosis

    We hypothesize that overexpression of bone morphogenetic protein 2 may be the underlying mechanism of osteoporosis and recurrent fractures. 2015 Wiley Periodicals, Inc.[ncbi.nlm.nih.gov] Excerpt This first-ever Surgeon General’s Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens.[ncbi.nlm.nih.gov] Figures and Tables - Analysis 4.2 Comparison 4 Musculoskeletal pain, Outcome 2 Lower limb pain 4 years.[doi.org] A similar increase in risk was observed for animal protein, but no association was found for consumption of vegetable protein.[doi.org]

  • Fibrodysplasia Ossificans Progressiva

    Abstract Bone morphogenetic protein (BMP) receptor kinases are tightly regulated to control development and tissue homeostasis.[ncbi.nlm.nih.gov] M 4 .[ncbi.nlm.nih.gov] First, the pathway forms a cartilage scaffold, then transforms it into bone. The result is normal bone – not just mineral deposits – in the wrong places.[philly.com] Abstract Transforming growth factor-β family members, which include TGF-βs, activins and bone morphogenetic proteins (BMPs), play important roles in development and maintaining[ncbi.nlm.nih.gov]

  • Vitamin K

    Matrix Gla protein (MGP) and bone morphogenetic protein-2 in aortic calcified lesions of aging rats. J Thromb Haemost. 2003;1(1):178–85.[dx.doi.org] Vitamin K has been purported to play an important role in bone health.[ncbi.nlm.nih.gov] Despite this great difference, the origin of tissue menaquinone-4 has yet to be exclusively defined.[ncbi.nlm.nih.gov] Approximately 60% of protein S in human plasma is bound to the complement regulatory protein C4b-binding protein (C4BP) in a high-affinity, high-molecular-weight complex.[ncbi.nlm.nih.gov]

  • Diamond-Blackfan Anemia

    Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice . Am. J. Physiol. Gastrointest.[doi.org] KEYWORDS: Anemia, Diamond-Blackfan; Bone Marrow Transplantation; Erythrocyte Enzyme Deficiency; Red Cell Enolase Deficiency[ncbi.nlm.nih.gov] […] report a case of a 16-year-old Japanese boy suffering from multiple colon tumors during the follow-up after hematopoietic stem cell transplantation for DBA at the age of 4.[ncbi.nlm.nih.gov] , along with rarer abnormalities of additional ribosomal proteins.[ncbi.nlm.nih.gov]

  • Familial Pulmonary Arterial Hypertension

    Mutations in the bone morphogenetic protein receptor 2 (BMPR2) have been identified in at least 70% of FPAH patients.[ncbi.nlm.nih.gov] However, the proproliferative effect of BMP-4 on peripheral PASMCs was found to be p38MAPK/ERK-dependent.[ncbi.nlm.nih.gov] KEYWORDS: BMPR2; ERAD; FPAH; Missense mutations; Protein misfolding[ncbi.nlm.nih.gov] Abstract Heterozygous germ line mutations in the gene encoding the bone morphogenetic protein (BMP) type II receptor occur in more than 80% of patients with familial pulmonary[ncbi.nlm.nih.gov]

  • Monoclonal Gammopathy of Undetermined Significance

    Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts.[bloodjournal.org] A number of studies have investigated the relationship between MGUS and bone health outcomes including bone mineral density (BMD), osteoporosis and fractures, but no meta-analysis[ncbi.nlm.nih.gov] Mikulasova A 1, 2, 3, 4 , Smetana J 1, 2 , Wayhelova M 1, 2 , Janyskova H 1 , Sandecka V 5 , Kufova Z 4, 6 , Almasi M 7 , Jarkovsky J 8 , Gregora E 9 , Kessler P 10 , Wrobel[ncbi.nlm.nih.gov] RESULTS: Surface-receptor clustering and endocytosis of receptor-ligand (immunoglobulin M/protein zero) complexes were pronounced after exposure to protein zero.[ncbi.nlm.nih.gov]

  • Hypercalcemia of Malignancy

    […] tumor cells are responsible for osteolytic lesions, and tumor cell production of factors that stimulate osteoblast proliferation, such as fibroblast growth factors, bone morphogenetic[jaoa.org] Similar to other bisphosphonates, ibandronate exhibits antitumor activity and prevents or reduces bone metastases.[ncbi.nlm.nih.gov] METHODS: Patients with hypercalcemia of malignancy, defined as an albumin-corrected serum calcium level or 12.0 mg/dl, were treated with a single dose of zoledronic acid, 4[ncbi.nlm.nih.gov] Over the past decade, studies have shown that parathyroid hormone-related protein is the cause of the HHM syndrome, and recent data suggest that this protein may also play[ncbi.nlm.nih.gov]

  • Urinary Tract Infection

    Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection .[doi.org] The 2 patients described in this report, one with a T1 pathologic fracture and another with widespread bone and lymph node metastases from an unknown primary tumor, underwent[ncbi.nlm.nih.gov] Therefore, CHF1 was further characterized by NMR and FTIR analysis and based on the structure elucidated, the compound was found to be 3,3',4'-Trihydroxyflavone.[ncbi.nlm.nih.gov] Bacterial Vaccines Cytokines Immunoglobulin A Immunoglobulin G Immunoglobulin Isotypes Interleukin-17 Recombinant Proteins mrpA protein, Proteus mirabilis Flagellin Interferon-gamma[ncbi.nlm.nih.gov]

  • Osteogenesis Imperfecta

    Finally, absence of the type I collagen C-propeptidase bone morphogenetic protein 1 (BMP1) causes type XII osteogenesis imperfecta due to altered collagen maturation/processing[ncbi.nlm.nih.gov] […] fragility of bone.[patient.info] To reduce cellular stress, mutant fibroblasts were treated with the FDA-approved chemical chaperone 4-phenylbutyric acid.[ncbi.nlm.nih.gov] It encodes two isoforms, bone morphogenetic protein 1 (BMP1) and mammalian tolloid (mTLD); both have proteolytic activity to remove the C-propeptide from procollagen.[ncbi.nlm.nih.gov]

  • Brachydactyly

    […] additional occurrence of proximal symphalangism and carpal synostosis, we identified six different point mutations (P35A, P35S, A36P, E48K, R167G, and P187S) in the bone morphogenetic[ncbi.nlm.nih.gov] We found a novel heterozygous missense mutation c.1336T C in exon 4 of the PDE3A gene in a Japanese family with multiple HTNB patients.[ncbi.nlm.nih.gov] We propose a model in which the RRS versus the BDB1 phenotype is determined by the relative degree of protein retention/degradation and the amount of mutant protein reaching[ncbi.nlm.nih.gov] However, brachydactyly in association with absence of nasal bone is rare.[ncbi.nlm.nih.gov]