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10,894 Possible Causes for 4, bromodomain, containing, mouse, protein

Did you mean: 4, bromodomain, containing, morus, proteus

  • Diffuse Intrinsic Pontine Glioma

    The high level of MYCN in DIPG led us to test sequential therapy with the bromodomain inhibitor JQ1 and MRK003, and we found that JQ1 and MRK003 inhibited DIPG growth and[ncbi.nlm.nih.gov] Here we describe a novel mouse model targeting these same genetic alterations to Pax3-expressing cells, which in the neonatal mouse pons consist of a Pax3 /Nestin /Sox2 population[ncbi.nlm.nih.gov] (IL-4) signaling axis components (IL-4, interleukin 13 (IL-13), and their respective receptors IL-4Rα, IL-13Rα1, and IL-13Rα2).[ncbi.nlm.nih.gov] The radiology repository contains 3558 studies from 448 patients.[ncbi.nlm.nih.gov] Protein profiling identified 2,305 unique proteins indicating distinct DIPG protein expression patterns compared to other pediatric brain tumors.[ncbi.nlm.nih.gov]

  • Thyroid Cancer

    Next, it was demonstrated that GA decreased the expression of bromodomain‑containing protein 4 (BRD4), which has been reported to function as an oncogene in various types[ncbi.nlm.nih.gov] […] troglitazone (an agonist of peroxisome proliferator-activated receptor gamma, PPARγ), exhibits anti-proliferation in cell culture systems and leads to tumor regression in a mouse[ncbi.nlm.nih.gov] UCA1 knockdown significantly inhibited PTC cell viability, colony formation and the bromodomain containing 4 (BRD4) expression level in vitro, and retarded PTC tumor growth[ncbi.nlm.nih.gov] In the xenograft mouse model, BANCR overexpression in the thyroid cancer cells significantly increased tumor growth.[ncbi.nlm.nih.gov] Severi G 1 , Bernardini L 2 , Briuglia S 3 , Bigoni S 4 , Buldrini B 4 , Magini P 1 , Dentici ML 5 , Cordelli DM 6 , Arrigo T 3 , Franzoni E 6 , Fini S 4 , Italyankina E 4[ncbi.nlm.nih.gov]

  • Retinoblastoma

    The identification of hyperphosphorylated protein kinases including Bromodomain containing 4 (BRD4), Lysine deficient protein kinase 1 (WNK1), and Cyclin-dependent kinase[ncbi.nlm.nih.gov] KEYWORDS: cancer cell of origin; cone photoreceptor; genetically engineered mouse models; retinoblastoma; retinoma[ncbi.nlm.nih.gov] Sid Ahmed S 1 , Messali Z 1 , Poyer F 2, 3 , Lumbroso-Le Rouic L 4 , Desjardins L 4 , Cassoux N 4, 5 , Thomas CD 2, 3 , Marco S 2, 3 , Lemaitre S 2, 3, 4, 5 .[ncbi.nlm.nih.gov] Abstract Recent evidence shows that Disheveled-Axin domain containing 1 (DIXDC1) is dysregulated in various cancers.[ncbi.nlm.nih.gov] A C-terminal LxCxE motif in ORFV119 enabled the protein to interact with the retinoblastoma protein (pRb) a multifunctional protein best known for its tumor suppressor activity[ncbi.nlm.nih.gov]

  • Progeria

    […] cells from patients with Hutchinson Gilford Progeria Syndrome (HGPS), who typically do not develop cancer, contain a tumor protection mechanism that is mediated by BRD4 (Bromodomain-containing[cancer.gov] ICMT inhibition increased AKT-mTOR signaling and proliferation and delayed senescence in human HGPS fibroblasts but did not reduce the levels of misshapen nuclei in mouse[ncbi.nlm.nih.gov] Chen Z 1, 2 , Chang WY 1 , Etheridge A 3 , Strickfaden H 4 , Jin Z 4 , Palidwor G 1, 5 , Cho JH 3 , Wang K 3 , Kwon SY 1, 6 , Doré C 1 , Raymond A 1 , Hotta A 7 , Ellis J[ncbi.nlm.nih.gov] Since the LMNA promoter contains a retinoic acid responsive element, we investigated if all-trans retinoic acid administration could lower progerin levels in cultured fibroblasts[ncbi.nlm.nih.gov] […] information 1 Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. [email protected] Abstract A clinical trial of a protein[ncbi.nlm.nih.gov]

  • Respiratory Syncytial Virus

    We demonstrate that RSV replication induces RelA to complex with bromodomain-containing protein 4 (BRD4), a cofactor required for RNA polymerase II (Pol II) phosphorylation[ncbi.nlm.nih.gov] We have previously established a mouse model of RSV-induced exacerbation of allergic airways disease, which mimics hallmark clinical features of asthma.[ncbi.nlm.nih.gov] We found that RSV-induced NRF2 degradation occurs in an SUMO-specific E3 ubiquitin ligase - RING finger protein 4 (RNF4)-dependent manner.[ncbi.nlm.nih.gov] These results indicated that V5 VLP vaccine containing tandem repeat gene protein provided better protection than V1 VLPs with significantly decreased inflammation in the[ncbi.nlm.nih.gov] Here, we show that HRSV Matrix (M) protein interacts with the cellular adaptor protein complex 3 specifically via its medium subunit (AP-3Mu3A).[ncbi.nlm.nih.gov]

  • Sucrose

    Abstract Bromodomains (BRDs) are epigenetic interaction domains currently recognized as emerging drug targets for development of anticancer or anti-inflammatory agents.[ncbi.nlm.nih.gov] To validate the interference of S. epidermidis sucrose fermentation with P. acnes , mouse ears were injected with both P. acnes and S. epidermidis plus sucrose or phosphate[ncbi.nlm.nih.gov] M 3 , Kreis H 3, 4 , Timsit MO 4, 12 , Legendre C 3, 4, 5 .[ncbi.nlm.nih.gov] When using a glycine-containing immunoglobulin no acute renal impairment was observed in this patient.[ncbi.nlm.nih.gov] Invariably, the process of protein aggregation is associated with both a loss of the normal biological function of the protein and a gain of toxic function that ultimately[ncbi.nlm.nih.gov]

  • Skin Infection

    Here, we describe a mouse model of skin and soft tissue infection induced by subcutaneous inoculation of S. aureus.[ncbi.nlm.nih.gov] When a definition of 4 F was used, results were similar (4-point, P .15; whole wound, P .20).[ncbi.nlm.nih.gov] Each gram of ointment contains 2% sodium fusidate in an ointment base containing lanolin. Each gram of cream contains 2% fusidic acid.[medsask.usask.ca] Antimicrobial proteins produced by snake venoms have recently attracted significant attention due to their relevance to bacterial infection and potential development into[ncbi.nlm.nih.gov] Isogenic hla-negative (Deltahla) strains caused skin lesions in a mouse infection model that were significantly smaller than those caused by wild-type USA300 and Newman strains[ncbi.nlm.nih.gov]

    Missing: bromodomain
  • Premature Aging

    Resistance is mediated by the bromodomain protein BRD4, which exhibits altered genome-wide binding patterns in transformation-resistant cells, leading to inhibition of oncogenic[ncbi.nlm.nih.gov] We first confirmed the existence of a reduction in GDF11/8 levels in our mouse model of accelerated aging compared with wild-type littermates.[ncbi.nlm.nih.gov] She had many manifestations of the Mulvihill-Smith syndrome, a disorder that has been described in 4 sporadic individuals, ranging in age from 4 to 17 years.[ncbi.nlm.nih.gov] The chapter contains a detailed description of the clinical features of both disorders and then it focuses on the genetics, the resulting biochemical alterations at the protein[ncbi.nlm.nih.gov] In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins.[ncbi.nlm.nih.gov]

  • Ureteral Obstruction

    Bromodomain and extra-terminal (BET) protein inhibitors have been shown to effectively ameliorate pathological fibrotic responses.[ncbi.nlm.nih.gov] We investigated the effect of vascular endothelial growth factor (VEGF)-C on lymphangiogenesis, inflammation, and fibrosis in the mouse kidney using the unilateral ureteral[ncbi.nlm.nih.gov] RESULTS: Two patterns of obstruction were observed: early, during the first 3-4 days post-operation, in four patients (4 ureters; 3%) which was associated with transient hydroureteronephrosis[ncbi.nlm.nih.gov] Six days after completing a 4-week induction therapy containing 9 doses of L-asparaginase, severe left abdominal pain developed.[ncbi.nlm.nih.gov] Proteins from the groups of CUUO and corresponding sham rat kidney tissues were subjected to 2-D gel electrophoresis, and then protein identification by mass spectrometry.[ncbi.nlm.nih.gov]

  • Respiratory Syncytial Virus Infection

    In vivo , poly(I·C)-induced neutrophilia and mucosal chemokine production are blocked by a small-molecule BRD4 bromodomain inhibitor.[ncbi.nlm.nih.gov] We examined the effects of dietary bovine colostrum on virus infection and CD8 T cell responses following hRSV infection in the mouse model.[ncbi.nlm.nih.gov] BACKGROUND: While genetic polymorphisms in Toll-like Receptor 4 (TLR4) have been demonstrated to play an important role in respiratory syncytial virus (RSV) infections in[ncbi.nlm.nih.gov] Abstract Cytologic examination of a bronchoalveolar lavage specimen from a 6-year-old bone marrow transplant recipient revealed pulmonary infiltrates and occasional cells containing[ncbi.nlm.nih.gov] Conjugation inhibition assays demonstrated that ISG15 exerts its antiviral activity via protein ISGylation.[ncbi.nlm.nih.gov]