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629 Possible Causes for 4A5, Phosphodiesterase, Specific, cAMP

Did you mean: 4A5, Phosphodiesterase, Specific, coma

  • Acrodysostosis

    Two PRKAR1A patients each with a novel mutation presented a specific pattern of brachydactyly. One PDE4D patient presented with acroskyphodysplasia.[ncbi.nlm.nih.gov] Beyond the missing residues, the entire capping motif is disordered (residues 357-379) and explains the disrupted cAMP binding.[ncbi.nlm.nih.gov] […] acrodysostosis (ACRDYS2), a rare developmental skeletal dysplasia characterized by short stature, severe brachydactyly and facial dysostosis, is caused by mutations in the phosphodiesterase[ncbi.nlm.nih.gov] Her recent work has focused on development of small molecule drugs, particularly phosphodiesterase-2 and 9 inhibitors, on central nervous system disorders. Dr.[books.google.com]

    Missing: 4A5
  • Phobia

    Exposure based treatments in which patients are systematically confronted with their feared objects of situations are highly effective in the treatment of specific phobias[ncbi.nlm.nih.gov] […] analog 8-Br-cAMP, suggesting that the cellular effects of naloxone or CTAP in modulating extinction are mediated by cAMP inhibition that would occur with μ opioid receptor[doi.org] Specific Phobias Specific Phobias As the name suggests, a person with a Specific Phobia experiences intense fear in response to an object or situation.[web.archive.org] Similarly, Monti et al. 282 reported that rolipram, a phosphodiesterase inhibitor that increases cAMP concentrations in the brain, facilitates acquisition of fear and delays[doi.org]

    Missing: 4A5
  • Pseudohypoparathyroidism

    OBJECTIVE: To clarify the usefulness of methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA), we evaluated genetic and epigenetic changes of the[ncbi.nlm.nih.gov] Moreover, mutations in PRKAR1A and PDE4D, which encode proteins crucial for G s α–cAMP-mediated signalling, have been found in patients with acrodysostosis.[nature.com] Disorders Theophylline Bronchodilator Agents Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Asthmatic Agents Respiratory System Agents Phosphodiesterase[clinicaltrials.gov] GPCRs) and several downstream intracellular effectors, including the heterotrimeric stimulatory G-protein (Gs), the cAMP-dependent protein kinase A (PKA), and cAMP-specific phosphodiesterases[ncbi.nlm.nih.gov]

    Missing: 4A5
  • Benign Prostatic Hyperplasia

    TPV, total prostate specific antigen, and duration of BPH were significantly lower in group 1 than those in group 2.[ncbi.nlm.nih.gov] McVary KT , Monnig W , Camps Jr JL , Young JM , Tseng LJ , van den Ende G .[doi.org] This includes a detailed history and physical exam, as well as initiation of a number of medications such as alpha-blockers, 5-alpha reductase inhibitors and phosphodiesterase[ncbi.nlm.nih.gov] This classical paradigm is being challenged by antimuscarinics, 5-phosphodiesterase inhibitors (PDE5i) and β3-adrenoreceptor agonists.[ncbi.nlm.nih.gov]

    Missing: 4A5
  • Pulmonary Hypertension

    Left atrial area of 26.8 cm 2 and 30.0 cm 2 were optimal specific thresholds for identification of PAWP   15 and 18 mm Hg, had sensitivity of 60%/53% and specificity 89%/94%[ncbi.nlm.nih.gov] […] hypotension as inactivated when bound to Hb) milrinone (50mcg/kg bolus - 0.2-0.8mcg/kg/min) dipyridamole (0.2-0.6mg/kg IV over 15min bd) inhaled prostacyclin (increases cAMP[lifeinthefastlane.com] […] that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic nucleotide phosphodiesterases[doi.org] PDE1 has 3 isoforms that are regulated by calcium-calmodulin and can hydrolyze both cAMP and cGMP.[doi.org]

    Missing: 4A5
  • Primary Pigmented Nodular Adrenocortical Disease

    Adrenal specific ablation of Prkar1a leads to resurgence of foetal features Adrenocortical-specific ablation of the Prkar1a gene led to expansion of hypertrophic eosinophilic[doi.org] […] analog 8Br-cAMP.[ncbi.nlm.nih.gov] […] patients with a micronodular form of BAH that we have called "isolated micronodular adrenocortical disease" (iMAD) in whom CS was associated with inactivating mutations in phosphodiesterase[ncbi.nlm.nih.gov] Isolated PPNAD is a genetic heterogenous disease, and recently inactivating mutations of the gene of the phosphodiesterase 11A4 (PDE11A4) located at 2q31-2q35 have been identified[ncbi.nlm.nih.gov]

    Missing: 4A5
  • Atopic Dermatitis

    Randomised controlled trials (RCTs) of specific allergen immunotherapy that used standardised allergen extracts in people with AE.[ncbi.nlm.nih.gov] Clinical photographs of atopic dermatitis (A) before and (B) after “eczema boot camp,” an intensive 2-week topical therapy outpatient regimen.[doi.org] Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis.[ncbi.nlm.nih.gov] Apremilast, an oral phosphodiesterase-4 inhibitor, was FDA approved in September 2014 for the treatment of moderate-to-severe plaque psoriasis.[ncbi.nlm.nih.gov]

    Missing: 4A5
  • Atopy

    Asthma, specifically, has been observed to be a risk factor for lung cancer.[ncbi.nlm.nih.gov] Previous studies to that by Hanifin report in AD a cAMP lower intracellular levels, which act by inhibiting the cellular functions, also demonstrating low cAMP levels in leukocytes[omicsonline.org] The odds ratio for sum of abnormal specific IgE measurements was 0.77 (0.44-1.34).[ncbi.nlm.nih.gov] Prevalence of reported wheeze was 2% in under-fives and 5% in participants 5 years; 19% had a positive SPT; median Dermatophagoides-specific IgE and cockroach-specific IgE[ncbi.nlm.nih.gov]

    Missing: 4A5
  • Hypersensitivity

    We developed a specific questionnaire to be completed by anesthesiologists.[ncbi.nlm.nih.gov] Thophylline elevates cAMP by inhibiting cAMP-phosphodiesterase and inhibits intracellular Ca release is also used to relieve bronchopulmonary symptoms.[microbiologybook.org] CASE PRESENTATION: We report a pediatric case of haemophagocytic lymphohistiocytosis with specific presentation which predominantly featured as acute necrotizing encephalopathy[ncbi.nlm.nih.gov] The presence of serum IgE antibodies to specific sequential epitopes of ovomucoid may be used as a screening instrument for persistent egg allergy.[ncbi.nlm.nih.gov]

    Missing: 4A5
  • Hypertension

    A layer-specific analysis of myocardial deformation in all adults revealed that all of the peak systolic longitudinal strain (LS) and the peak systolic circumferential strain[ncbi.nlm.nih.gov] Crossref Medline Google Scholar 110 Camp NJ, Hopkins PN, Hasstedt SJ, Coon H, Malhotra A, Cawthon RM, Hunt SC.[doi.org] Note that thrombolytics are contraindicated if the BP is above 185/100 mm Hg. [28] In addition, note that nitrates administered in the presence of phosphodiesterase type 5[emedicine.com] Houweling, Johan Quispel, Norbert Beier, Pieter D Verdouw, Dirk J Duncker and Daphne Merkus , Endothelial dysfunction enhances the pulmonary and systemic vasodilator effects of phosphodiesterase[doi.org]

    Missing: 4A5