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6,997 Possible Causes for 5, Absolute, Brain, CTCAE, Count, Grade, Infection, Neutrophil, Unknown, with

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  • Febrile Neutropenia

    Polymicrobial infection in patients with cancer: an underappreciated and underreported entity. Clin Infect Dis. 2007;45:228-233. 29.[uspharmacist.com] Conjunctiva l Petechiae (endocarditis) Roth Spot s on fundus (endocarditis) Neurologic findings Altered Level of Consciousness ( Meningitis ) Focal neurologic deficit ( Brain[fpnotebook.com] The definition of FN was used the criteria of CTCAE (ver. 4.0).[erj.ersjournals.com] All studies included people with cancer with fever of unknown origin and excluded people with microbiological documented infections.[cochrane.org] The patient's clinical manifestations resolved 5 days later.[ncbi.nlm.nih.gov] The proportion of severe adverse events (CTC-NCI grades 3/4) was low in both periods (4 and 1%).[bloodjournal.org] Neutropenia is defined as an absolute neutrophil count (polymorphonuclear cells plus band forms) of 500/ml or less.[jpgmonline.com] […] available electronic medical record data between January 2009 and December 2011, we examined cases of chemotherapy -induced neutropenia reported in our hospital using the CTCAE[journals.lww.com] In the USA, a mortality rate associated with grade 3 and 4 neutropenia ranging from 3.4 % to 10.5% with an overall mortality ranging from 6.8% to 9.5% was reported Ozguler[medcraveonline.com] It is defined as a temperature higher than 38.3 degrees Celsius or 100.5 degrees Farenheit in the presence of any severity of neutropenia, which is typically an absolute neutrophil[mdmag.com]

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  • Lymphocytopenia

    infection.[ncbi.nlm.nih.gov] A pathological diagnosis of PML was made by brain biopsy.[ncbi.nlm.nih.gov] Lymphopenia was classified according to CTCAE (Common Terminology Criteria for Adverse Events) version 4.[doi.org] After cord blood transplantation, CD4( ) lymphocytopenia from unknown causes was observed, and persistent infections with human parvovirus B19 (B19) occurred.[ncbi.nlm.nih.gov] Comment to Haematologica. 2011;96(8):1221–5 Haematologica April 2012 97: e9-e11; doi: 10.3324/haematol.2011.058669 We read with interest a recent article in Haematologica[haematologica.org] A significant correlation of total leukocyte count and NLCR, but not lymphocyte count, with parasitaemia was found.[ncbi.nlm.nih.gov] Likewise, the neutrophil-lymphocyte count ratio (NLCR) has been shown a simple promising method to evaluate systemic inflammation in critically ill patients.[ncbi.nlm.nih.gov] In univariate analysis, subnormal absolute lymphocyte count (ALC) 9 /l; P 0.001), ALC 9 /l (P 0.0002), subnormal absolute monocyte count (AMC) 9 /l (P 0.0003), LMR (P 0.0001[ncbi.nlm.nih.gov] A brain biopsy performed 4 months after symptom onset established the diagnosis of PML.[nn.neurology.org] Background: Idiopathic CD4 lymphocytopenia (ICL) is a rare disorder of unknown etiology.[ingentaconnect.com]

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  • Meningitis

    […] causing the infection).[web.archive.org] Brain abscess is a focal infection of the brain parenchyma, commonly caused by bacterial, fungal, and parasitic pathogens.[ncbi.nlm.nih.gov] However, the cost effectiveness of such algorithms is unknown.[ncbi.nlm.nih.gov] Furthermore, the assay's validity was evaluated testing 5 pooled CSF samples positive for different pathogens.[ncbi.nlm.nih.gov] We assessed the overall quality of evidence using the GRADE (Grades of Recommendation, Assessment, Development and Evaluation) approach.[ncbi.nlm.nih.gov] Every second counts. Meningitis is a medical emergency. It can develop in a number of hours. It’s important to know the warning signs and to get medical treatment fast.[meningitis.com.au] Cerebrospinal fluid (CSF) analysis revealed pleocytosis with neutrophil predominance, increased protein and low glucose. CSF and blood cultures yielded negative results.[ncbi.nlm.nih.gov] Five studies of 587 patients compared atraumatic needles with standard needles and found a nonsignificant decrease in the odds of headache with an atraumatic needle (absolute[ncbi.nlm.nih.gov] Unknown status NCT01478035 Phase 4 Phenytoin;placebo 2 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Unknown status NCT02686853[malacards.org] Cerebrospinal fluid collected through lumbar puncture showed increased eosinophil count and third-stage Angiostrongylus cantonensis larvae.[ncbi.nlm.nih.gov]

    Missing: CTCAE with
  • Cyclic Neutropenia

    Abstract Atraumatic Clostridium septicum infection is rare in infancy and childhood and is associated with a high mortality rate.[ncbi.nlm.nih.gov] New Tests Hydrocephalus, Congenital 2 with or without Brain or Eye Anomalies via MPDZ Gene Sequencing with CNV Detection ( #12013 ) Pediatric Cancer Sequencing Panel with[preventiongenetics.com] Abstract Fever of unknown origin (FUO) is the diagnosis associated with a variety of infectious, neoplastic, or rheumatic/inflammatory disorders.[ncbi.nlm.nih.gov] Epidemiology Most patients present before the age of 5 years: 32% are 27% are between ages 1 and 5 years.[unboundmedicine.com] Further work up of the patient for high grade fever and occasional leukopenias revealed the diagnosis of cyclic neutropenia.[ncbi.nlm.nih.gov] Cyclic therapy with G-CSF (5 micrograms/kg/d s.c. for 1 week every 21 d) maintained peripheral neutrophil count above the normal range, reduced the incidence of severe infections[ncbi.nlm.nih.gov] The authors hypothesized that congenital neutropenia is also due to mutations of neutrophil elastase.[ncbi.nlm.nih.gov] When G-CSF therapy was discontinued, the leukocyte and absolute neutrophil counts again declined.[ncbi.nlm.nih.gov] Brain Dev. 2013 May;35(5):449-53. 3: Hiramoto T et al.[home.hiroshima-u.ac.jp] Because of its rarity, location, and an unknown association with CN, we found this case worthwhile to publish.[ncbi.nlm.nih.gov]

    Missing: CTCAE with
  • Congenital Neutropenia

    Abstract Severe congenital neutropenia is one of primary immunodeficiency disorders that characterized by severe neutropenia and is associated with severe systemic bacterial infections[ncbi.nlm.nih.gov] Moreover, two alternative HAX1 splice variants were identified in normal human tissues, including the brain.[ncbi.nlm.nih.gov] RESULTS: ELANE mutations correlated with more severe periodontal status than the HAX1 or unknown mutations in patients with SCN.[ncbi.nlm.nih.gov] We present the case of a 5-month old male with congenital neutropenia who developed severe TAH during treatment with granulocyte colony-stimulating factor (G-CSF).[ncbi.nlm.nih.gov] Cumulative incidence (day 90) of acute graft-versus-host disease (GVHD) grade 2-4 was 21%.[ncbi.nlm.nih.gov] Treating a low white blood cell count A blood test can tell you if your white blood cell count is low.[nhs.uk] These results demonstrate that precursors containing the mutation are selectively lost during myelopoiesis or fail to develop into neutrophils.[ncbi.nlm.nih.gov] […] nationwidechildrens.org Abstract Severe congenital neutropenia is an autosomal recessive disorder characterized by maturation arrest at the promyelocyte/myelocyte phase in the bone marrow, absolute[ncbi.nlm.nih.gov] Fungal infections may lead to serious complications in immunodeficient patients.[ncbi.nlm.nih.gov] She died 1 year after being diagnosed with a diffuse large B cell non-Hodgkin’s lymphoma in the brain at the age of 72.[link.springer.com]

    Missing: CTCAE with
  • Agranulocytosis

    Treatment of agranulocytosis consists of the immediate and permanent withdrawal of the offending drug and control of the infection with antibiotics.[britannica.com] […] nikhil.a.huprikar.mil@mail.mil Abstract Superficial siderosis of the central nervous system is a rare neurological disorder caused by deposits of haemosiderin on subplial brain[ncbi.nlm.nih.gov] High-dose methylprednisolone therapy should thus be considered for patients demonstrating ANA-positive agranulocytosis with an unknown etiology that is refractory to G-CSF[ncbi.nlm.nih.gov] Pharmacogenomics J. 2017 Oct;17(5):471-478. doi: 10.1038/tpj.2016.32.[ncbi.nlm.nih.gov] He was diagnosed as dengue hemorrhagic fever, grade I because he had hemoconcentration, thrombocytopenia without bleeding and positive IgM dengue antibody On the 5th day,[ncbi.nlm.nih.gov] Results: At the onset of agranulocytosis, the median administration period of MMI was 33 days, the average white blood cell count was 1 896/μL, and the median neutrophil count[ncbi.nlm.nih.gov] Evaluation of a peripheral blood smear showed leukopenia with severe absolute neutropenia.[ncbi.nlm.nih.gov] Prevailing low grade fever may progress into a high fever or hypothermia along with rapid breathing, confusion, and body swelling.[explainmedicine.com] Medical Center Utrecht, Utrecht, The Netherlands. 3 Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Center, Donders Institute for Brain, Cognition[ncbi.nlm.nih.gov] However, the exact incidence and risk factors of this complication in patients with nephrotic syndrome remain unknown.[ncbi.nlm.nih.gov]

    Missing: CTCAE with
  • Kostmann Syndrome

    There was no admitting history to the hospital related to infection, and he has resumed a normal life style with regular school attendance.[jahjournal.org] Neurological examination, hearing test, and brain magnetic resonance imaging were normal.[doi.org] […] of apoptosis in SCN, bone marrow aspirates and biopsies were obtained from 4 patients belonging to the kindred originally described by Kostmann and 1 patient with SCN of unknown[ncbi.nlm.nih.gov] One patient died at age 2 from neurological complications, while two other patients, including one who underwent a hematopoietic stem cell transplantation (HSCT) at age 5,[ncbi.nlm.nih.gov] The latest classification schemes and criteria for malignancy, incorporated throughout, enable you to include the most current gradings in your reports.[books.google.com] , and a differential count showing 86 percent eosinophils.[ncbi.nlm.nih.gov] Mutations in the transcriptional repressor GFI1 and the cytoskeletal regulator WASP also lead to defective neutrophil production.[doi.org] Primary Familial Brain Calcification Eliana Marisa Ramos, Joao Oliveira, Maria J Sobrido, and Giovanni Coppola.[ncbi.nlm.nih.gov] […] congenital neutropenia (SCN) constitutes a primary immunodeficiency syndrome associated with increased apoptosis in myeloid cells, yet the underlying genetic defect remains unknown[ncbi.nlm.nih.gov] At 7 months of age, he was referred to the pediatric hematology with high-grade fever persisting for 20 days and suffering from diarrhea lasting for 1 week.[jahjournal.org]

    Missing: CTCAE with
  • Felty's Syndrome

    Register NEUTROPENIA AND INFECTIONS IN FELTY'S SYNDROME - 24 Hours access EUR 36.00 GBP 28.00 USD 45.00 Rental This article is also available for rental through DeepDyve.[rheumatology.oxfordjournals.org] It causes blood clots to form in the body's small blood vessels, including vessels in the brains, kidneys, and heart.[nhlbi.nih.gov] Abstract A 63-year old man with Felty's syndrome and pneumonia of unknown origin was treated with GM-CSF.[ncbi.nlm.nih.gov] Clin Rheumatol. 2013 May;32(5):701-4. doi: 10.1007/s10067-012-2157-3. Epub 2013 Jan 5. Author information 1 B.[ncbi.nlm.nih.gov] She complains of low-grade fever and chills at home. She also complains of pain and swelling on the left chin.[omicsonline.org] Both of these patients had initial poly counts above 1000/mm3.[ncbi.nlm.nih.gov] ANCA, detected by indirect immunofluorescence on ethanol-fixed neutrophils, was found in 77% of 30 patients with FS and in 36% of 50 RA patients.[ncbi.nlm.nih.gov] Absolute neutrophil counts rose from 0.1 to 2.2 x 10(9)/l and remained 1.0 x 10(9)/l 8 weeks after discontinuation of the GM-CSF therapy.[ncbi.nlm.nih.gov] Their application in the management of Felty's syndrome with intercurrent infection has raised concern that resultant neutrophilia and activation of a diverse array of polymorphonuclear[ncbi.nlm.nih.gov] The cause of Felty syndrome is unknown. It is more common in people who have had rheumatoid arthritis (RA) for a long time.[nlm.nih.gov]

    Missing: CTCAE with
  • Barth Syndrome

    For affected individuals with confirmed neutropenia, complications due to bacterial infection are often preventable by ongoing monitoring and early therapy of suspected infections[checkorphan.org] Neurol. 38 (5):305-13 (PMID: 18410845) Zeviani et al. (2004) Brain 127 (Pt 10):2153-72 (PMID: 15358637) Taylor et al. (2014) JAMA 312 (1):68-77 (PMID: 25058219)[genedx.com] In some cases, a new mutation of the gene occurs randomly for unknown reasons.[childrenshospital.org] 代謝 本疾患で認められる3-メチルグルタコン酸尿症は,ミトコンドリア機能障害による二次的な3-メチルグルタコン酸増加が原因と考えられるが,その機序は十分に解明されていない 27) .現在,3-メチルグルタコンサン尿症は5型に分けられ,Barth症候群はII群に分類されている 5, 6) .3-メチルグルタコン酸尿は診断に有用であるが, TAZ[jpccs.jp] Data from these boys were compared to data from 15 typically developing boys individually matched on age and grade in school to each of the 15 boys with Barth syndrome.[dx.doi.org] Comparisons of reported events for the population suggest that patients with baseline neutrophil counts 0.5 x 10 9 /L have more infections than patients with higher counts[bloodjournal.org] (A,D,F) Freshly purified control neutrophils; (B) neutrophils from the same donor after overnight culture with more than 80% annexin-V binding; (C,E,G) freshly purified neutrophils[dx.doi.org] Laboratory analysis revealed low total white blood cell count (absolute count: 4000 cells per microL) in 25% of those who were not on granulocyte colony-stimulating factor[ncbi.nlm.nih.gov] These blood clots may block blood vessels and block blood flow to important organs, including the brain, heart, and lungs.[health24.com] Barth syndrome is due to mutations in the TAZ gene, the exact function of which is unknown but there are indications that it is directly involved in the metabolism of cardiolipin[genome.jp]

    Missing: CTCAE with
  • Temozolomide

    Lymphocytopenia is reported to be the most frequent and severe adverse effect of TMZ and leads to opportunistic infections.[ncbi.nlm.nih.gov] […] irradiation (WBI) in patients with brain metastases.[dx.doi.org] Two patients experienced no toxicity per CTCAE guidelines.[ncbi.nlm.nih.gov] Continuous daily dosing is available, but the acceptable dose and duration of therapy is unknown.[ncbi.nlm.nih.gov] Ichimura K 10 , Sakai R 5 , Namba H 11 , Mori K 7 .[ncbi.nlm.nih.gov] Hematological toxicity was seen in six patients (18%): grade 1 neutropenia in four, grade 2 thrombocytopenia in one, and grade 4 thrombocytopenia plus grade 1 neutropenia[doi.org] […] is 100,000/mm 3 . 1 Withhold next cycle until these counts are exceeded; adjust subsequent dosages based on nadir hematologic measurements (i.e., ANC and platelet counts)[drugs.com] Patients with a 40% decrease in neutrophils showed significantly longer OS than those with[ncbi.nlm.nih.gov] Her absolute lymphocyte counts were 156/μL on admission. Cultures obtained from the wound yielded Aspergillus fumigatus.[ncbi.nlm.nih.gov] The optimal treatment of pituitary carcinomas (PC) is unknown. Treatment includes surgical resection, radiation, and more recently, temozolomide (TMZ).[ncbi.nlm.nih.gov]

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