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6,592 Possible Causes for 5,, catalytic, phosphatase, protein, rat, subunit

Did you mean: 5, catalytic, phosphatase, proteus, rat, subunit

  • Phosphorylase Kinase Deficiency

    […] to the skipping of exon 4, which results in a frameshift, starting at nucleotide 272, a premature stop codon after 32 additional amino acids, and subsequent loss of the catalytic[ncbi.nlm.nih.gov] […] storage diseases such as GSD due to liver phosphorylase deficiency (GSD type VI), GSD due to glycogen debranching enzyme deficiency (GSD type III), and GSD due to glucose-6-phosphatase[orpha.net] The complete coding sequences of the liver gamma subunit and of the beta subunit of phosphorylase kinase of the proband were analyzed for the presence of mutations, by either[ncbi.nlm.nih.gov] Maire I, Sovik O, Kilimann MW (1996) Mutations in the testis/liver isoform of the phosphorylase kinase gamma subunit (PHKG2) cause autosomal liver glycogenosis in the gsd rat[doi.org] L) but an exaggerated 5-fold increase in ammonia (peak 197 and 171 μmol/L; control peak range 60-113 μmol/L).[ncbi.nlm.nih.gov] The report of a pathogenic mutation (R531Q) in the gene (PRKAG2) encoding the gamma2 subunit of AMP-activated protein kinase (AMPK) in three infants with congenital hypertrophic[ncbi.nlm.nih.gov]

  • Influenza

    Further reading Comparative studies of catalytic pathways for Streptococcus pneumoniae sialidases NanA, NanB and NanC Kela Xiao , Xingyong Wang & Haibo Yu Scientific Reports[doi.org] Amplicons were prepared for sequencing by incubating them at 37  C for 60 min with 0.5 U of shrimp alkaline phosphatase (Amersham) and 1 U of exonuclease I (Amersham) to inactivate[dx.doi.org] Influenza subunit vaccine - ten years experience. Europ J Clin Res 1992; 3: 117-38. [ Links ] 3. Nichol KL, Lind A, Margokis KL, et al .[scielo.org.ar] Three clinical toxicology studies identified neurotoxicity in newborn rats administered this medication.[ncbi.nlm.nih.gov] ; yields live virus) A and B NP 5 swab, throat swab, NP 5 or bronchial wash, nasal or endotracheal aspirate, sputum; (specimens placed in VTM 8 ) 1-3 days No Viral tissue[cdc.gov] Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40 , 627–633 (1985). 5. Zebedee, S.L. & Lamb, R.A.[doi.org]

  • Lafora Disease

    This suggested, as also observed by others, that it could present two domains, a carbohydrate-binding domain (CBM20, known as a starch-binding domain) and the catalytic domain[ncbi.nlm.nih.gov] Laforin contains a dual specificity phosphatase domain and a carbohydrate-binding module, and is a member of the recently described family of glucan phosphatases.[ncbi.nlm.nih.gov] Here we show that, in addition, laforin interacts with itself and with the glycogen targeting regulatory subunit R5 of protein phosphatase 1 (PP1).[ncbi.nlm.nih.gov] The human, mouse, and rat orthologs of EPM2A are 94% similar at the amino acid level ( 16 ).[doi.org] Jansen , Lafora Disease , Encyclopedia of Movement Disorders , 10.1016/B978-0-12-374105-9.00338-5 , (113-116) , (2010) .[doi.org] Binary interactions i GO - Molecular function i identical protein binding Protein-protein interaction databases Structure i 3D structure databases Family & Domains i Phylogenomic[expasy.org]

  • LIG4 Syndrome

    Catalytically inactive Dnl4 protein does not impede DSB resection.[journals.plos.org] Mikio Shimada, Lavinia C Dumitrache, Helen R Russell and Peter J McKinnon , Polynucleotide kinase–phosphatase enables neurogenesis via multiple DNA repair pathways to maintain[doi.org] Epub 2004 Jun 11. 2004 23XRCC6, LIG4, PRKDC, XRCC4, XRCC5 Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4[genatlas.medecine.univ-paris5.fr] Reaktivitäten zu anti-Ligase IV, DNA, ATP-Dependent (LIG4) Antikörper Wählen Sie die Spezies und Applikation aus anti-Human Antikörper: anti-Mouse (Murine) Antikörper: anti-Rat[antikoerper-online.de] Figure 5.[academic.oup.com] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[mcb.asm.org]

  • Osteoporosis

    Pathogenic variants may result in various consequences, sometimes cumulative: decrease or abolition of the catalytic activity; inability to form homodimers; sequestration[ncbi.nlm.nih.gov] Overexpression of microRNA‑148a significantly reduced estrogen receptor a (ERα) protein expression and suppressed phosphoinositide‑3‑kinase regulatory subunit 1 (PI3K) and[ncbi.nlm.nih.gov] Osteoporotic rats were treated with ABPs, and serum was then sampled for metabolic analysis.[ncbi.nlm.nih.gov] Risedronate 5 mg vs Control ‐ all years baseline denominators Comparison 5.[doi.org] A similar increase in risk was observed for animal protein, but no association was found for consumption of vegetable protein.[doi.org] Autophagy-related proteins [ 36 ] IFNA4, IFNA5, IFNA7, IFNA8, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21 , Interferon α proteins [ 36 ] PIK3C3 Phosphatidylinositol 3-kinase catalytic[doi.org]

  • Glycogen Storage Disease due to Muscle Phosphorylase Kinase Deficiency

    Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.[uniprot.org] , catalytic subunit glucose-6-phosphatase, catalytic (glycogen storage disease type i, von gierke disease glucose-6-phosphatase, catalytic, 1 G6PC G6PC1 G6PT GSD1A 613742[ukgtn.nhs.uk] Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.[uniprot.org] Purification of rat liver phosphorylase b kinase. J. Biol. Chem. 257 (1982) 10798–10804 Google Scholar Cohen, P.[link.springer.com] Arch Neurol 38(5):279–81 Google Scholar 45.[link.springer.com] […] kinases such as protein kinase A (PKA, cAMP-dependent kinase).[en.wikipedia.org]

  • Spinocerebellar Ataxia Type 12

    Functional PP2A consists of a structural unit, one of two catalytic units, and one of 30 regulatory subunits, with the N-terminal region of the regulatory subunits serving[grantome.com] This hypothesis would predict that the mutation changes the regulation of protein phosphatase 2A, with implications for the phosphoproteome.[ncbi.nlm.nih.gov] […] action tremor, mild cerebellar dysfunction, and hyperreflexia, genetic testing revealed abnormal CAG repeat length in the brain-specific protein phosphatase 2, regulatory subunit[ncbi.nlm.nih.gov] The neurotoxic effect of PPP2R2B overexpression was examined in transfected rat primary neurons.[ncbi.nlm.nih.gov] Nature Genet. 18 , 72– 75 (1998). 5. Ott, J. Analysis of Human Genetic Linkage (Johns Hopkins University Press, Baltimore, 1991). 6. Mayer, R.E. et al.[nature.com] […] spots, which were confirmed as nine proteins by LC-MS/MS.[ncbi.nlm.nih.gov]

  • Intermediate Maple Syrup Urine Disease

    In "Thiamin: Catalytic Mechanisms and Roles in Normal and Disease States" (Jordan, F., and Patel, M. S. eds.) Marcel Dekker, Inc., New York, pp. 449-469, 2004.[www4.utsouthwestern.edu] The phosphatase that removes the inhibitory phosphate is encoded by the PPM1K (protein phosphatase, Mg 2 /Mn 2 dependent 1K) gene located on chromosome 4q22.1 and is composed[themedicalbiochemistrypage.org] No detectable assembly of the F364C E1α subunit with normal E1β was observed during the 2 h chase.[utsouthwestern.influuent.utsystem.edu] […] hydroxytryptamine; 5-HT)) through competition via the large neutral amino acid transporter.[ncbi.nlm.nih.gov] Zero levels of protein should be given at this stage.[zekesfundraiser.org.au] PP2Cm is a phosphatase that reactivates the BCKDH complex in the presence of excess branched- chain amino acids.[invitae.com]

  • Cantharidin

    […] metal ion and a non-catalytic phenylalanine residue, the latter of which is substituted by tryptophan in PP4C.[ncbi.nlm.nih.gov] Its cytotoxicity is believed to be mediated by the inhibition of serine/threonine protein phosphatase 2A.[ncbi.nlm.nih.gov] […] α (IKKα) and NF‑κB inhibitor α (IκBα) in cells, and an increased NF‑κB p65 subunit level in the nucleus.[ncbi.nlm.nih.gov] After treatment with compounds 3-12, primary cultured rat hepatocytes exhibited no cytotoxicity (IC(50) 200 microM).[ncbi.nlm.nih.gov] […] cream nightly for an average of 5 weeks.[ncbi.nlm.nih.gov] […] cell-permeable, potent and specific inhibitor of serine/threonine protein phosphatases 1 2 and 2A 3 by competitively docking in the ligand binding site at the beta catalytic subunit[alomone.com]

  • Carney Complex

    To accomplish this goal, we introduced null alleles of the PKA catalytic subunits Prkaca (Ca) or Prkacb (Cb) into the Prkar1a-cardiac knockout (R1a-CKO) or limited Schwann[ncbi.nlm.nih.gov] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. ‏[books.google.com] Torgersen KM, Vaage JT, Levy FO et al. (1997) Selective activation of cAMP‐dependent protein kinase type I inhibits rat natural killer cell cytotoxicity.[els.net] RESULTS: Within the pedigree, ten patients with CNC were identified, and a novel heterozygous mutation (c.440 5 G C in intron 4a) was identified in the PRKAR1A gene.[ncbi.nlm.nih.gov] AMP-Dependent Protein Kinase RIalpha Subunit PRKAR1A protein, human RNA, Messenger RNA, Small Interfering SMAD3 protein, human Smad3 Protein Transforming Growth Factor beta[ncbi.nlm.nih.gov] The truncated protein is expressed, but rapidly degraded, and does not interact with the protein kinase A catalytic subunit.[ncbi.nlm.nih.gov]