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24 Possible Causes for 5 fluoro , acid,, orotic

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  • Hyperammonemia

    […] valproic acid pharmacokinetics and its toxic effect.[ncbi.nlm.nih.gov] Other intermediate catabolites of 5-FU, dihydrofluorouracil, and alpha-fluoro-beta-ureidopropionic acid were not changed.[ncbi.nlm.nih.gov] Further investigation revealed an increased orotic acid level in the urine, suggesting a urea cycle disorder (UCD).[ncbi.nlm.nih.gov]

  • Flumazenil

    […] hastening of emergence from general anesthesia has largely focused on activating subcortical monoaminergic networks, with little attention on antagonizing the γ-aminobutyric acid[ncbi.nlm.nih.gov] -3-carboxylate # Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-3-carboxylate ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4[molinstincts.com] Abnormally high levels of orotic acid were found in serum and urine, confirming the diagnosis of ornithine transcarbamylase deficiency.[ncbi.nlm.nih.gov]

  • Fluorouracil

    ; licensee BioMed Central Ltd. 2004 Received: 13 April 2004 Accepted: 20 July 2004 Published: 20 July 2004 Abstract Background Combination therapy of irinotecan, folinic acid[bmccancer.biomedcentral.com] Other names: 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-; Fluorouracil; Uracil, 5-fluoro-; Efudex; Fluoroplex; Fluracil; Fluril; NSC 19893; Ro 2-9757; 5-Fluoro-2,4(1H,3H)-Pyrimidinedione[webbook.nist.gov] Its metabolites, oxypurinol, can inhibit orotate phosphoribosyl transferase and thus reduce the toxicity and may improve the therapeutic index.[chemicalbook.com]

  • Hereditary Orotic Aciduria

    acid.[mayomedicallaboratories.com] It reduces toxicity and cell-death associated with two cytotoxic intermediates: 5-fluoro-2'-deoxyuridine-5'-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP).[drugbank.ca] Conclusion Patients with orotic aciduria with and without megaloblastic anemia cannot be distinguished by ratio of orotic acid to orotidine.[ncbi.nlm.nih.gov]

  • Antimetabolite

    Azahomofolic acid and its derivatives were ineffective.[molpharm.aspetjournals.org] fluoro-2'-deoxyuridine (FdUrd)] is summarized.[ncbi.nlm.nih.gov] Ring closure through intramolecular Schiff base formation (3) yields dihydroorotate, and subsequent dehydrogenation (4) produces orotate.[watcut.uwaterloo.ca]

  • Dihydropyrimidine Dehydrogenase Deficiency

    […] constitutes the first step of the pyrimidine degradation pathway in which the pyrimidine bases uracil and thymine are catabolised to beta-alanine and beta-aminoisobutyric acid[ncbi.nlm.nih.gov] 5-fluorouracil NAD 5-fluoro-5,6-dihydrouracil NADH - - - - ? 5-fluorouracil NAD 5-fluoro-5,6-dihydrouracil NADH H 5-fluorouracil NAD ?[brenda-enzymes.org] Jakobs C, Sweetman L, Nyhan WL, Gruenke L, Graig JC, Wadman SK (1984) Stable isotope dilution analysis of orotic acid and uracil in amniotic fluid.[springerlink.com]

  • Disorder of Pyrimidine Metabolism

    Human catabolizes purine (Adenine & Guamine) to uric acid, which is relatively insoluble aicd.[gradestack.com] Molecules of this class include 5-fluorouracil (fluorouracil: 5-FU), 5-fluorodeoxyuridine (floxuridine; FUdR), and 5-fluoro-2'-deoxyuridine monophosphate (FUdR-MP).[themedicalbiochemistrypage.org] See also specific forms, such as aminoaciduria, orotic aciduria. orotic aciduria appearance of orotic acid, an intermediate of pyrimidine synthesis, in the urine due to a[medical-dictionary.thefreedictionary.com]

  • Moderately-Differentiated Thymic Neuroendocrine Carcinoma

    […] occasional to rare patterns Spindle cell Oncocytic Pigmented (melanin or lipofuscin) Angiectatic With amyloid stroma (calcitonin positive carcinoid) With mucinous stroma (acidic[surgpathcriteria.stanford.edu] In vivo, 5-FU is converted to its active form, 5-fluoro-2′-deoxyuridine-5′-monophosphate (FdUMP).[link.springer.com] Periodic acid-Schiff and mucicarmine stains were negative in the tumor cells in all cases.[nature.com]

  • Leflunomide

    : This study determined that leflunomide reduced serum uric acid concentrations through increased urinary excretion of uric acid, which might not reflect changes in disease[ncbi.nlm.nih.gov] Structure Chemical Name CAS MF p-tert-butyl propiophenone N/A C6H4ClN3 PamidronicAcid 2-Fluoro-4-[(trans,trans)-4'-propyl[1,1'-bicyclohexyl]-4-yl]benzonitrile 93743-04-5 C22H30FN[chemicalbook.com] Teriflunomide, just like the mother drug, inhibits dihydro-orotate dehydrogenase and synthesis of pyrimidine.[ncbi.nlm.nih.gov]

  • Chylomicronemia Syndrome

    acid.[atvb.ahajournals.org] fluoro-2’-deoxyuridylate 5-fluoro-2’-desoxiuridilato FEF frontal eye fields campos oculares frontales [corteza premotora] FEV 1 forced expiratory capacity in 1 s capacidad[harrisonmedicina.mhmedical.com] […] disorders with hyperammonemia treatment Hyperhomocysteinemia megaloblastic anemia treatment Hyperhomcysteinemia treatment Mental retardation with Megaloblastic Anemia and high orotic[quizlet.com]