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1,769 Possible Causes for 55A,, Drosophila, Protein, Y, AT, phosphatase

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  • Ataxia Telangiectasia

    METHODS: Retrospective study comprising all 52 patients (aged 2-26.2 y) followed at a national AT Clinic.[ncbi.nlm.nih.gov] The activity of the HDAC4 phosphatase, protein phosphatase 2A (PP2A), is downregulated by ATM-mediated phosphorylation.[ncbi.nlm.nih.gov] Louis–Bar syndrome Boder-Sedgwick syndrome Louis Bar syndrome ataxia telangiectasia syndrome AT At, Complementation Group C ATAXIA-TELANGIECTASIA ATAXIA-TELANGIECTASIA; AT[wikidata.org] Other mammalian ortholog(s) used D. melanogaster Gene Information (1) Comments on ortholog(s) Ortholog of human ATM (1 Drosophila to 1 human).[flybase.org] Here we identified that Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT.[ncbi.nlm.nih.gov] G Ppp4c protein phosphatase 4, catalytic subunit 1 198,219,012 198,225,775 RGD:8661242 G Ppp5c protein phosphatase 5, catalytic subunit 1 78,944,054 78,968,361 RGD:8661232[rgd.mcw.edu]

    Missing: 55A
  • LIG4 Syndrome

    -M.; Dai, Y.; Stumm, M.; Kysela, B.; Hirsch, B.; Gennery, A.; Palmer, S. E.; Seidel, J.; Gatti, R. A.; Varon, R.; Oettinger, M. A.; Neitzel, H.; Jeggo, P.[humpath.com] Mikio Shimada, Lavinia C Dumitrache, Helen R Russell and Peter J McKinnon , Polynucleotide kinase–phosphatase enables neurogenesis via multiple DNA repair pathways to maintain[doi.org] ATR-Seckel syndrome is caused by mutations in ataxia telangiectasia and Rad3 related protein (ATR), a component of a DNA damage signalling pathway.[ncbi.nlm.nih.gov] MATERIALS AND METHODS Drosophila DNA Ligase IV gene analysis: The Drosophila DNA Ligase IV gene ( Lig4 ) was identified by screening the Berkeley Drosophila Genome Project[genetics.org] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[mcb.asm.org] […] important vertebrate Gtf that -O-GlcNAcylates a multitude of nuclear and cytoplasmic protein, including transcription elements, cytoskeletal protein, metabolic enzymes, kinases, phosphatases[perlierusa.com]

    Missing: 55A
  • Dementia

    Y 3 , Kuzuhara S 4 , Abe K 5 .[ncbi.nlm.nih.gov] Jeon, Young-Won Chin, Byung-Soo Koo and Kyoung Sang Cho , In Vivo Screening of Traditional Medicinal Plants for Neuroprotective Activity against Aβ42 Cytotoxicity by Using Drosophila[doi.org] The pathogenesis of AD is complex, involving specific disease-linked proteins (amyloid-beta [Aβ] and tau), inflammation, and neurotransmitter dysregulation.[ncbi.nlm.nih.gov] Abstract We present a case of memory loss and aphasia in a 72-y-old man and discuss how PET imaging supported a diagnosis of Alzheimer dementia despite conflicting clinical[ncbi.nlm.nih.gov] The pathogenesis of AD is complex, involving specific disease-linked proteins (amyloid-beta [Aß] and tau), inflammation, and neurotransmitter dysregulation.[doi.org] Yamamoto T , Kondo K , Hirai H , Nakade M , Aida J , Hirata Y .[doi.org]

    Missing: 55A phosphatase
  • Gonadoblastoma

    Y gene deletion PCR assays.[ncbi.nlm.nih.gov] TSPY protein localized with established germ cell tumor markers, such as the placental alkaline phosphatase, c-KIT, and OCT3/4, in the same tumor cells of both gonadoblastoma[ncbi.nlm.nih.gov] 7928059 ) van der Bijl A.E....de Jong D. 1994 11 Ovarian gonadoblastoma with dysgerminoma in a woman with two normal children. ( 2744756 ) Nakashima N....TAKEUCHI J. 1989 12 Ataxia-telangiectasia[malacards.org] To study the TSPY protein expression, an anti-fusion protein antibody was used for immunohistochemistry of the patient's gonads.[ncbi.nlm.nih.gov] Three cases of gonadoblastomas and fetal gonads of both sexes were analyzed using oncofetal markers to M2A-antigen (M2A), germ cell alkaline phosphatase (PLAP/GCAP), receptor[ncbi.nlm.nih.gov] […] chromosome material appears to participate in gonadoblastoma tumorigenesis ( Am J Clin Pathol 1997;108:197 , Birth Defects Res C Embryo Today 2009;87:114 ) Associated with ataxia-telangiectasia[pathologyoutlines.com]

    Missing: 55A Drosophila
  • Progeria

    Similarly, Drosophila bred for longevity have displayed increased levels of small heat shock proteins [JOURNALS OF GERONTOLOGY; Kurapati,R; 55A(11):B552-B559 (2000)].[benbest.com] Conversely, ROCK inactivation with Y-27632 abolished their interaction, concomitant with ROS reduction.[ncbi.nlm.nih.gov] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. ‎ Pagina 22 - R. (1997).[books.google.ro] […] information 1 Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. [email protected] Abstract A clinical trial of a protein[ncbi.nlm.nih.gov] […] acyl-CoA dehydrogenase very long chain ACAN : aggrecan ACAT1 : acetyl-CoA acetyltransferase 1 ACE : angiotensin I converting enzyme ACOX1 : acyl-CoA oxidase 1 ACP5 : acid phosphatase[ghr.nlm.nih.gov] The binding of XPA to the stalled forks excludes normal binding by repair proteins, leading to DSB accumulation, which activates ATM (ataxia telangiectasia mutated) and ATR[biochemsoctrans.org]

  • Cantharidin

    -Y. Tsai, J.-G. Chung, J.-H. Chiang, K.-T. Chen, Y.-C. Chen, H.-Y. Chen, Y.-F. Chen, J.-S. Yang, Int. J. Oncol. 2011 , 38 , 1067.[tcichemicals.com] Its cytotoxicity is believed to be mediated by the inhibition of serine/threonine protein phosphatase 2A.[ncbi.nlm.nih.gov] Cantharidin (5, 10, and 15 μM) treatment of NCI-H460 cells reduced protein levels of ataxia telangiectasia mutated (ATM), breast cancer 1, early onset (BRCA-1), 14-3-3 proteins[ncbi.nlm.nih.gov] […] adios to Spanish Fly and meet its distant cousin, Spanish Fruit Fly--with both wine and ripened fruit, this fermentation combination is the ultimate elixir of love for the Drosophila[blogs.scientificamerican.com] Results from western blotting showed that cantharidin inhibited the expression of DNA-dependent serine/threonine protein kinase, poly-ADP ribose polymerase, phosphate-ataxia-telangiectasia[ncbi.nlm.nih.gov] 016773303.1, Bactrocera dorsalis JAC38805.1, Bombyx mori NP_001093298.1, Bombus terrestris NP_001295235.1, hrysomela populi ABO37162.1, Culex quinquefasciatus EDS41396.1, Drosophila[doi.org]

    Missing: 55A
  • Influenza

    Y , Osaki S , Ryuto M , Sakaguchi S , Sakayori S , Sasaki Y , Sato S , Sato T , Sato Y , Sato Y , Segawa Y , Shibasaki A , Shimamoto E , Shimomura H , Sugiura T , Suzuki[ncbi.nlm.nih.gov] The bound antibodies were detected with an alkaline phosphatase-conjugated antibody against mouse (Sigma).[dx.doi.org] Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila . Nature 423 , 715–719 (2003) 12 Webster, R. G., Bean, W.[dx.doi.org] Amplicons were prepared for sequencing by incubating them at 37  C for 60 min with 0.5 U of shrimp alkaline phosphatase (Amersham) and 1 U of exonuclease I (Amersham) to inactivate[dx.doi.org] Xu X Y, Subbarao K, Cox N J, Guo Y J.[pubmedcentral.nih.gov] Sequence based analysis demonstrated substantial changes in the HA protein over the last decade.[ncbi.nlm.nih.gov]

    Missing: 55A AT
  • Cerebellar Ataxia

    M 3 , Tsurusaki Y 3 , Miyake N 3 , Saitsu H 3 , Matsumoto N 3 , Tanaka F 1 .[ncbi.nlm.nih.gov] […] acetylcholine receptor antibodies); anti GAD65 antibodies; SSA, SSB antibodies (Sjögren’s antibodies); antigliadin antibodies (IgA and IgG); serum iron studies; alkaline phosphatase[practicalneurology.com] Drosophila modeling revealed that UBA5 knockdown induced locomotive defects and a shortened lifespan accompanied by aberrant neuromuscular junctions (NMJs).[ncbi.nlm.nih.gov] ADCK3 encodes a mitochondrial protein which functions as an electron-transfer membrane protein complex in the mitochondrial respiratory chain (MRC).[ncbi.nlm.nih.gov] Doi H 1 , Koyano S 2 , Miyatake S 3, 4 , Nakajima S 5 , Nakazawa Y 6 , Kunii M 2 , Tomita-Katsumoto A 2 , Oda K 7 , Yamaguchi Y 7 , Fukai R 2 , Ikeda S 2 , Kato R 8 , Ogata[ncbi.nlm.nih.gov] Ataxia-telangiectasia. A , Axial T2 image shows cortical thinning and fissure enlargement in the vermis and cerebellar hemispheres.[ajnr.org]

    Missing: 55A
  • Spinocerebellar Ataxia Type 1

    Nakayama T 1 , Nakayama K , Takahashi Y , Ohkubo K , Tobe H , Soma M , Ozawa Y , Kanmatsuse K , Nakamura M , Hironaga T , Makizumi Y , Nagura H .[ncbi.nlm.nih.gov] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. ‏ الصفحة 129 - Brook JD, McCurrach ME, Harley HG et al.[books.google.com] telangiectasia syndrome Ataxia-telangiectasia syndrome Azorean disease Azorean disease, type II Bailey-Cushing syndrome Corticostriatal spinal degeneration Corticostriatal-spinal[icd9data.com] We applied this approach, which integrates parallel cell-based and Drosophila genetic screens, to spinocerebellar ataxia type 1 (SCA1), a disease caused by expansion of a[ncbi.nlm.nih.gov] Here we show that the expanded polyglutamine tract differentially affects the function of the host protein in the context of different endogenous protein complexes.[ncbi.nlm.nih.gov] Imon Y, Katayama S, Kawakami H, Murata Y, Oka M, Nakamura S.[doi.org]

    Missing: 55A
  • Ataxia-Telangiectasia-Like Disorder Type 1

    Dürr A, Cossee M, Agid Y, et al. : Clinical and genetic abnormalities in patients with Friedreich’s ataxia . N Engl J Med 1996, 335 :1169–1175.[link.springer.com] G Ppp4c protein phosphatase 4, catalytic subunit 1 198,219,012 198,225,775 RGD:8661242 G Ppp5c protein phosphatase 5, catalytic subunit 1 78,944,054 78,968,361 RGD:8661232[rgd.mcw.edu] A prominent example of this principle is provided by examination of three such disorders: ataxia-telangiectasia (A-T) caused by lack or inactivation of the ATM protein kinase[ncbi.nlm.nih.gov] CACNL1A4 EA2 FHM HPCA MHP MHP1 SCA6 601011 1388 calcium/calmodulin dependent serine protein kinase calcium/calmodulin-dependent serine protein kinase (MAGUK family) CAMGUK, drosophila[ukgtn.nhs.uk] 1 Inflammation, a significant player of Ataxia-Telangiectasia pathogenesis?[malacards.org] Shiloh Y, Gygi SP, Elledge SJ.[ncbi.nlm.nih.gov]

    Missing: 55A

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