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5,941 Possible Causes for 6, BREAKPOINT, SARCOMA,, SYNOVIAL,, X

  • Soft Tissue Sarcoma

    Synovial sarcoma derives its name from the fact that microscopically it resembles normal synovium.[radiopaedia.org] Abstract We present two cases in which a soft-tissue sarcoma metastasized to the pancreas, but both patients survived as a result of repetitive surgical treatment during a 6-[ncbi.nlm.nih.gov] Although 30% of subcutaneous soft tissue sarcomas behave less aggressively.[symptoma.com] […] situ hybridization (FISH) analysis of an aggressive undifferentiated soft tissue sarcoma diagnosed as primitive neuroectodermal tumor (PNET) revealed an insertion ins(4;X)[ncbi.nlm.nih.gov] Bull Exp Biol Med. 2017 Jun;163(2):260-262. doi: 10.1007/s10517-017-3779-x. Epub 2017 Jul 18.[ncbi.nlm.nih.gov]

  • Synovial Sarcoma

    […] to arise adjacent to joints, indicated a synovial origin; however, the actual cells from which the tumor develops are unknown and not necessarily synovial. [3] Primary synovial[en.wikipedia.org] We investigated how alterations in the cyclin D1-CDK4/6-Rb axis impact prognosis and studied effects of targeting this axis with the CDK4/6 inhibitor palbociclib.[ncbi.nlm.nih.gov] PMID 1657367 Translocations involving the X chromosome in solid tumors: presentation of two sarcomas with t(X;18)(q13;p11).[atlasgeneticsoncology.org] Candidate intronic primers were designed to detect the intronic fusion breakpoint and this fusion sequence was confirmed in intron 10 of SYT and intron 5 of SSX2 by genomic[ncbi.nlm.nih.gov] The synovial sarcoma, X breakpoint 1 gene-fusion transcript was detected by reverse transcription-polymerase chain reaction. It is diagnostic of PPSS.[ncbi.nlm.nih.gov]

  • Retinoid

    The crystal structures of the apo and holo forms of RXR have been resolved by X-ray crystallography (4,5).[umass.edu] Furthermore, we identified a patient with intellectual disability and a balanced translocation where one breakpoint truncates RORB and refined the phenotype of a recently[ncbi.nlm.nih.gov] The expression of GRIM19 in synovial tissues and RA-FLS was detected by real-time quantitative RT-PCR(qRT-PCR).The effects of GRIM19 on proliferation, migration, invasion,[ncbi.nlm.nih.gov] In fact, it can take up to six months for some less potent retinoids to make a visible improvement, but full-strength prescription treatments can also take 6-8 weeks.[stylecaster.com] Abstract Primary effusion lymphoma (PEL) is a rare B-cell neoplasm, associated with Kaposi sarcoma-associated herpes virus/human herpes virus-8 (KSHV/HHV-8), arising as malignant[ncbi.nlm.nih.gov]

  • Pulmonary Metastasis

    BACKGROUND: Primary pulmonary synovial sarcoma (PPSS) is rare.[ncbi.nlm.nih.gov] Jiang Y 1 , Yin J 1 , Chen R 1 , Ye D 1 , Wang Q 1 , Liu Z 1 , Liu S 1 , Cheng C 1 , Mao J 1 , Hou Y 2 , Wang M 3 , Siebenlist U 4 , Eugene Chin Y 1, 5 , Wang Y 1 , Cao L 6,[ncbi.nlm.nih.gov] […] demographics and tumor characteristics of patients with repeat pulmonary metastasis following complete resection of pulmonary metastases from osteogenic or soft tissue sarcoma[ncbi.nlm.nih.gov] Abstract Primary synovial sarcoma of kidney is an uncommon neoplasm, metastasizing most commonly to lung.[ncbi.nlm.nih.gov] CASE PRESENTATION: A 77-year-old woman was found to have a solitary pulmonary lesion 6 years after the initial treatment of sebaceous carcinoma of the eyelid.[ncbi.nlm.nih.gov]

  • Tuberculosis

    Approximately three-quarters of chest X-ray tests were normal (72.7%).[ncbi.nlm.nih.gov] RESULTS: In the development cohort, the mean ( SD) MIC of isoniazid below the breakpoint was 0.0334 0.0085 μg per milliliter in the relapse group and 0.0286 0.0092 μg per[ncbi.nlm.nih.gov] A synovial fluid sample and repeated wound swabs yielded no growth from routine bacterial culture.[ncbi.nlm.nih.gov] INTERVENTIONS: Anti-TB therapy with isoniazid, rifampicin, ethambutol, and pyrazinamide for 6 months. The skin ulcer completely healed after 6 months.[ncbi.nlm.nih.gov] Thoracic duct ligation and octreotide were required for only 17.1% (6/35) and 8.6% (3/35) of the patients, respectively.[ncbi.nlm.nih.gov]

    Missing: SARCOMA
  • Cat Eye Syndrome

    ,XXXYY 49,XXXXY Triple X syndrome (47,XXX) Tetrasomy X (48,XXXX) 49,XXXXX Jacobs syndrome (47,XYY) 48,XYYY 49,XYYYY 45,X/46,XY Translocations Leukemia / lymphoma Lymphoid[en.wikipedia.org] The larger type II CES chromosomes are either asymmetrical, with one breakpoint located in each of the two intervals, or symmetrical, with both breakpoints located in the[ncbi.nlm.nih.gov] Bid and adjacent gene Atp6e were found to map to mousechromosome 6, while the region homologous to the DGSCR is known to map to mouse chromosome 16.[ncbi.nlm.nih.gov] The margin of this region also delineates the boundary of conserved synteny between the CESCR and mouse chromosome 6.[ncbi.nlm.nih.gov] Distal 4q 33 Leiner Disease 23 Chromosome 4 Ring 34 LEOPARD Syndrome 24 Chromosome 4 Trisomy 4p 35 Lichen Planus 25 Chromosome 5 Trisomy 5p 36 Lichen Sclerosis 26 Chromosome 6[books.google.com]

  • X-Linked Ichthyosis

    X-linked ichthyosis is an X-linked disorder caused due to the deficiency of the enzyme - steroid sulfatase, which leads to the build-up of cholesterol sulfate in the skin.[symptoma.com] In ten cases the pulse-field evidence supports the clustering of breakpoints and indicates a deletion size of 2 Mb in most patients.[rspb.royalsocietypublishing.org] The DNA analysis showed that only exons 6-10 and the 5' flanking markers of the STS gene were present.[ncbi.nlm.nih.gov] […] and Randomized Patients in Two Arms With Soft Tissue Sarcoma of the Extremity and Trunk Wall Active, not recruiting NCT02379845 Phase 2, Phase 3 50 A Study of Doxorubicin[malacards.org] Malik A 1, 2, 3 , Amer AB 1, 2, 3 , Salama M 1, 2, 3 , Haddad B 1, 2, 3 , Alrifai MT 1, 2, 3 , Balwi MA 1, 2, 3 , Davies W 4, 5, 6, 7 , Eyaid W 8, 9, 10, 11 .[ncbi.nlm.nih.gov]

    Missing: SYNOVIAL
  • Epirubicin

    […] was shown to reverse repression of gene expression by translocation products such as PAX3/FKHR in alveolar rhabdomyosarcoma, EWS/FLI in Ewing's sarcoma, and SS18/SSX in synovial[annonc.oxfordjournals.org] Schouten PC 1 , Gluz O 2, 3 , Harbeck N 2, 4 , Mohrmann S 5 , Diallo-Danebrock R 5 , Pelz E 3 , Kruizinga J 6 , Velds A 6 , Nieuwland M 6 , Kerkhoven RM 6 , Liedtke C 2, 7[ncbi.nlm.nih.gov] ET-X (8.35 v 6.03 months).[ncbi.nlm.nih.gov] Significant breakpoint clustering was observed in PML and RARA loci ( P .009 and P .017, respectively), with PML breakpoints lying outside the mitoxantrone-associated hotspot[bloodjournal.org] At a median follow-up of 85·6 months (IQR 80·6-95·9) no significant difference was seen in the proportions of patients free from TTR events between the accelerated and standard[ncbi.nlm.nih.gov]

  • Fibrosarcoma

    Differential Diagnosis Nodular fasciitis Extra-abdominal desmoid fibromatosis Monophasic synovial sarcoma Malignant fibrous histiocytoma Leiomyosarcoma Dermatofibrosarcoma[surgpathcriteria.stanford.edu] J Clin Ultrasound. 2014 Jul-Aug;42(6):363-6. doi: 10.1002/jcu.22117. Epub 2013 Nov 27.[ncbi.nlm.nih.gov] We present a case of a 52-year-old female who presented with a sclerosing Muc-4-positive sarcoma with glandular differentiation of the sciatic nerve, resembling sclerosing[ncbi.nlm.nih.gov] Sources of penetrating radiation, including radioactive materials and x rays, are also associated with a risk of developing cancer, however, in most cases medical x rays have[symptoma.com] Fluorescence in situ hybridization studies showed rearrangement of Ewing sarcoma breakpoint region 1.[ncbi.nlm.nih.gov]

  • Mycobacterium Kansasii

    On admission, chest X-ray revealed multiple cavitary lesions and his sputnum yielded acid-fast bacilli, that were identified as Mycobacterium kansasii with multidrug resistance[ncbi.nlm.nih.gov] Linezolid was active against all isolates with MIC(50) and MIC(90) values of 0.5 and 1 mg/L, respectively, both below the susceptibility breakpoint established for mycobacteria[ncbi.nlm.nih.gov] Histological findings of the synovial biopsy revealed multinucleated giant cell epithelioid granuloma. Culture of synovial fluid grew Mycobacterium kansasii.[ncbi.nlm.nih.gov] We investigated esat-6 and cfp-10 genes in 22 clinical and 14 environmental isolates of M. kansasii.[ncbi.nlm.nih.gov] Bone biopsy showed granulocytic sarcoma. To our knowledge, this is the first reported case of life-threatening hemophagocytosis due to M. kansasii.[ncbi.nlm.nih.gov]

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