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6,372 Possible Causes for 65, Antibody:Substance, Concentration:Point, Glutamate, decarboxylase, fluid:Quantitative, IN, spinal, time:Cerebral

  • Flumazenil

    50924, Cologne, Germany. [email protected] Abstract Stiff Person Syndrome (SPS) is a rare autoimmune disorder associated with antibodies against glutamic acid decarboxylase[ncbi.nlm.nih.gov] This study investigated the effect of flumazenil on the hypnotic activity of propofol in 60 men scheduled for minor surgical procedures done under spinal anesthesia.[link.springer.com] Changes in brain GABA(A) receptors during substance use and withdrawal provide a neurobiological basis for craving and associated anxiety.[ncbi.nlm.nih.gov] BACKGROUND: It is unknown whether flumazenil antagonizes the decrease in cerebral blood flow or the alteration in dynamic cerebral autoregulation induced by midazolam.[ncbi.nlm.nih.gov] Evidence points to the GABAergic system being altered in DoC, making it a potential target as such a marker.[ncbi.nlm.nih.gov] […] directly compare the high-resolution research tomograph (HRRT) (high-resolution brain) and HR (standard whole-body) positron emission tomography (PET) only scanners for quantitative[ncbi.nlm.nih.gov] This study evaluated whether this finding is related to changes in neurocognitive performance, which is also affected by cortical GABA and glutamate tone.[ncbi.nlm.nih.gov] RESULTS: Twenty-three patients were included in the analysis, of which 15 (65%) of patients experienced some type of clinically significant mental status improvement.[ncbi.nlm.nih.gov] Significant benzodiazepine abstinence occurred with this flumazenil infusion method despite high levels of initial dependence, comorbid substance use and comorbid psychiatric[ncbi.nlm.nih.gov]

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  • Pyridoxine

    It is suggested that in addition to glutamic acid decarboxylase abnormality, the path from the absorption, transportation, phosphorylation, and oxidation of pyridoxine to[ncbi.nlm.nih.gov] Treatment outcome was monitored by cerebral-spinal-fluid (CSF) α-AASA measurements at baseline, 6th and 12th months of therapy.[ncbi.nlm.nih.gov] Pyridoxine: One of the vitamin B6 group (which also includes pyridoxal and pyridoxamine) that is transformed in the body to pyridoxal phosphate, which functions as a coenzyme, a substance[medicinenet.com] METHOD: Spanning a wide age range from birth to 48 years, corpus callosum morphology and cross-sectional cerebral area were measured in 30 individuals with PDE (12 males,[ncbi.nlm.nih.gov] Herein authors aim to present an expert point of view on PDEs in childhood, reviewing the most recent literature data and proposing a new therapeutical approach for seizures[ncbi.nlm.nih.gov] […] in the form of abnormal electromyography/nerve conduction study demonstrating a chronic sensory polyneuropathy and autonomic testing demonstrating abnormal responses to quantitative[ncbi.nlm.nih.gov] The CSF glutamate level was below the sensitivity of detection ([ncbi.nlm.nih.gov] Overview Key Specifications Table CAS # EC Number Hill Formula Molar Mass 65-23-6 200-603-0 C₈H₁₁NO₃ 169.17 g/mol Add To My Favorites Product has been Added to My Favorites[emdmillipore.com] There was greater improvement in symptoms scores with doxylamine-pyridoxine compared with placebo (0.73 points; 95% CI 0.21 to 1.25) when last observation carried forward[ncbi.nlm.nih.gov]

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  • Aseptic Meningitis

    KEYWORDS: Aseptic meningitis; bupivacaine; spinal anesthesia[ncbi.nlm.nih.gov] Aseptic/chemically induced* Meningitis, Aseptic/diagnosis Meningitis, Aseptic/physiopathology Middle Aged Tonsillar Neoplasms/drug therapy* Tonsillar Neoplasms/pathology Substances[ncbi.nlm.nih.gov] Cerebral salt-wasting syndrome often develops in patients with severe neurosurgical disorders, such as hydrocephalus, cerebral infarction, and tuberculous meningitis.[ncbi.nlm.nih.gov] 10,000 cells/mm3 (1 point) and seizures upon/before arrival (1 point).[ncbi.nlm.nih.gov] Medical Center, Rotterdam, The Netherlands. 8 Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Statistics and Quantitative[ncbi.nlm.nih.gov] glutamate-pyruvate transaminase).[ncbi.nlm.nih.gov] Epidemiol Infect. 2014 Oct;142(10):2159-65. doi: 10.1017/S0950268813003221. Epub 2013 Dec 19.[ncbi.nlm.nih.gov] Abstract Drug-associated headache is a quite common phenomenon, e.g. as a side effect of distinct substances such as nitric oxide or as a result of medication overuse of analgesic[ncbi.nlm.nih.gov] CONCLUSIONS: As the symptomatic attacks of spontaneous rupture of spinal teratoma resemble presentations of Mollaret meningitis, spinal teratoma should be considered in the[ncbi.nlm.nih.gov]

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  • Myasthenia Gravis

    Thymoma was detected, and both anti-glycine receptor and anti-glutamic acid decarboxylase antibodies were found.[ncbi.nlm.nih.gov] The central nervous system is comprised of the brain and spinal cord. The peripheral nervous system includes all peripheral nerves.[mountsinai.org] KEYWORDS: AChR antibodies; Experimental autoimmune myasthenia gravis (EAMG); MG patients; Myogenic factors Publication type, MeSH terms, Substances Publication type Research[ncbi.nlm.nih.gov] CASE PRESENTATION: A 54-year-old female was diagnosed with cerebral toxoplasmosis.[ncbi.nlm.nih.gov] Only a single patient presented an improvement of at least 20 points on MMS at M12, although 2 patients displayed an increase of at least 18 points at M12.[ncbi.nlm.nih.gov] Objective: To perform the translation, cross-cultural adaptation and validation of the Quantitative Myasthenia Gravis Score (QMGS) to Brazilian Portuguese in accordance with[ncbi.nlm.nih.gov] Here, we describe the case of a 65-year-old man with squamous cell lung carcinoma who developed myasthenia gravis (MG) after a third Nivo infusion.[ncbi.nlm.nih.gov] FEATURE The Comeback Kid An emergency medicine doctor returns to work within months of a life-changing spinal cord injury.[brainandlife.org] The mean QMG score at baseline (before pregnancy) was 7.4 points in five women with generalized forms of MG.[ncbi.nlm.nih.gov]

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  • Immunosuppressive Therapy

    Antibodies to glutamic acid decarboxylase (GAD) have been associated with a host of neurological disorders including stiff person syndrome, cerebellar ataxia, limbic encephalitis[ncbi.nlm.nih.gov] Spinal cord MRI showed longitudinally extensive transverse myelitis (LETM) and aquaporin-4-immunoglobulin-G (AQP4-IgG) was positive.[ncbi.nlm.nih.gov] […] lymphoma; Immunosuppressive therapy-associated lymphoproliferative disorders; Pancreatitis; Systemic lupus erythematosus (SLE); Tacrolimus Publication type, MeSH terms, Substances[ncbi.nlm.nih.gov] Although LYG cerebral lesions are usually located adjacent to LYG pulmonary lesions, few reports have described the occurrence of primary cerebral LYG.[ncbi.nlm.nih.gov] , and at the 6th month time point, the complete remission rate was still significantly higher in the non-PLA 2 R-associated group (46.2% versus 11.5%,p 0.007).[ncbi.nlm.nih.gov] Abstract This study aimed to review and quantitatively analyze (1) the association of aplastic anemia (AA) with human leukocyte antigen (HLA)-DRB1*15 and HLA-DRB1*15:01 polymorphisms[ncbi.nlm.nih.gov] Patients were stratified by age 65 at the start of follow-up, given differences in vaccination guidelines for the general population.[ncbi.nlm.nih.gov] Myocardial inflammation was assessed by quantitative immunohistology.[ncbi.nlm.nih.gov] […] risk factors related to the health service, such as control and reduction of the number of doses; related to the individual, such as being male, divorced, alcohol or other substances[ncbi.nlm.nih.gov]

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  • Epilepsy

    Abstract Antibodies against the 65-kDa isoform of the intracellular enzyme, glutamate decarboxylase (GAD65), have been found in patients with limbic encephalitis and drug-resistant[ncbi.nlm.nih.gov] […] and spinal cord — from the lumbar (or lower) region of the spinal column.[radiologyinfo.org] According to these rewarding pharmacological effects and chemical substances, the prescription of TCM herbs could be an effective therapeutic strategy for epilepsy patients[ncbi.nlm.nih.gov] CONCLUSIONS: Patients with typical facial features and cerebral cortical malformations associated with refractory epilepsy should be highly suspected BWCFF.[ncbi.nlm.nih.gov] Parametric two-point analysis suggested linkage with the greatest LOD score of 3.42 for the marker D9S286 at 9p24.1 at recombination fraction ( θ ) 0, 90% penetrance value[ncbi.nlm.nih.gov] Quantitative parameters of the intensity dynamic objectively distinguished frontal lobe seizures, establishing an observer independent tool for semiological seizure evaluation[ncbi.nlm.nih.gov] BACKGROUND/AIM: Excessive extracellular glutamate activates AMPA-type glutamate receptors (AMPA receptors) and induces seizures.[ncbi.nlm.nih.gov] When the cause can be determined, it is most often due to head injury, infections or a tumor in the brain, a stroke, degenerative diseases such as Alzheimer's disease, substance[health.ny.gov] KEYWORDS: Cerebral hemiatrophy; Contralateral EEG abnormalities; Hemispherotomy; Refractory epilepsy[ncbi.nlm.nih.gov]

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  • Coxsackie Virus

    PBMC in persons with or at increased risk for IDD show elevated reactivity to the beta cell enzyme glutamate decarboxylase (GAD).[ncbi.nlm.nih.gov] Abstract Acute transverse myelitis is a rare clinical manifestation of Coxsackie virus infection which cause acute and progressive debilitating illness associated with loss of spinal[ncbi.nlm.nih.gov] Publication type, MeSH terms, Substances, Grant support Publication type Research Support, Non-U.S.[ncbi.nlm.nih.gov] The diffuse slowing seen on EEG and seizure activity suggest that cerebral cortex was affected by the meningoencephalitis.[jamanetwork.com] In conclusion, the natural history of Coxsackie virus heart disease is characterized by two possibilities: a complete recovery from a clinical point of view, in some cases[ncbi.nlm.nih.gov] […] infection, with a 50% inhibitory concentration (IC(50)) from 2.66 to 6.62 microg/ml, but it also decreased the CVB(5)-RNA level in infected host cells, as shown in semi-quantitative[ncbi.nlm.nih.gov] CVB4 p2C-specific antibodies were not only detectable in GAD(65) antibody-positive diabetes patients but also in GAD(65) antibody-negative healthy blood donors.[ncbi.nlm.nih.gov] […] virus is strongly associated with the development of insulin-dependent diabetes mellitus in humans and shares sequence similarity with the islet autoantigen glutamic acid decarboxylase[ncbi.nlm.nih.gov] Filtration end points and sedimentation constants were measured by following the activity of the infectious particles.[jimmunol.org]

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  • Apomorphine

    In such cases, by means of effective preparations for oral use, we have utilized the synergistic effect of small amounts of apomorphine, L-dopa, and decarboxylase inhibitor[ncbi.nlm.nih.gov] It has been suggested that periodic leg movements (PLM) and spinal flexor reflex (FR) share common mechanisms.[ncbi.nlm.nih.gov] Both groups of substances are diminished within the Parkinsonian brain. 1 2 3 L-dopa administration might therefore increase both melanins and catecholamines. 4 The side effects[nejm.org] These findings are discussed in the context of current hypotheses of these agents' therapeutic mechanisms on cerebral function.[ncbi.nlm.nih.gov] RESULTS: In the crossover phase (n 28), least squares mean changes in the UPDRS part III score from pre-dose were -24.5 points with apomorphine and -2.3 points with placebo[ncbi.nlm.nih.gov] CONCLUSION: Our study was able to demonstrate quantitatively the efficacy of nocturnal apomorphine infusion in PD patients with nocturnal hypokinesia and demonstrated the[ncbi.nlm.nih.gov] […] the generation of excitotoxic glutamate in central nervous system disorders such as HIV-associated dementia (HAD) and multiple sclerosis.[ncbi.nlm.nih.gov] Expression of β-tubulin-3, Nestin and MAP2 confirmed neuronal differentiation whereas tyrosine hydroxylase, aromatic acid decarboxylase and dopamine transporter were expressed[ncbi.nlm.nih.gov] Drugs containing this substance are sometimes used in the treatment of Parkinson's disease or erectile dysfunction. In higher doses it is a highly effective emetic.[druglib.com]

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  • Cerebellar Ataxia

    Abstract Cerebellar ataxia associated with glutamic acid decarboxylase autoantibodies (GAD-ab) is a rare and usually slow progressive disease with moderate to severe gait[ncbi.nlm.nih.gov] External links [ edit ] List of movies and TV shows that mention or portray cerebellar ataxia Lady without cerebellum v t e Lesions of spinal cord and brain Spinal cord [en.wikipedia.org] Publication types, MeSH terms, Substances, Grant support Publication types Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S.[ncbi.nlm.nih.gov] Also like Ataxic Cerebral Palsy, Cerebral Ataxia has many different causes .[ataxiccerebralpalsyhelp.com] In light of these points, the potential mechanisms whereby cannabinoids may modulate the eCB system to ameliorate dysfunction associated with cerebellar ataxias are considered[ncbi.nlm.nih.gov] This case study provides, for the first time, a quantitative assessment of gait improvement in response to TMS therapy in ataxia, as well as neurophysiological evidence in[ncbi.nlm.nih.gov] Abstract Imaging of type 1 metabotropic glutamate receptor (mGluR1) has recently become possible using positron emission tomography (PET).[ncbi.nlm.nih.gov] Blood and cerebrospinal fluid serology, and imaging supported the diagnosis of GAD-65 cerebellar ataxia and epilepsy.[ncbi.nlm.nih.gov] Abstract Cerebellar ataxia is one of the most frequent syndromes associated with autoantibodies against glutamic acid decarboxylase (GAD-ab).[ncbi.nlm.nih.gov]

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  • Eikenella Corrodens

    Thus, lysine decarboxylases such as p80 inhibit growth by removing lysine from mammalian cell culture media.[ncbi.nlm.nih.gov] Abstract Spinal infections with Eikenella corrodens are rare.[ncbi.nlm.nih.gov] CONCLUSIONS: The heterogeneous antagonistic spectrum exhibited by E. corrodens isolates suggests their ability to produce more than one antagonistic substance, whose ecological[ncbi.nlm.nih.gov] Abstract A 2-year-old boy with underlying congenital cyanotic heart disease presented with seizures and fever and was found to have bilateral parietal cerebral abscesses.[ncbi.nlm.nih.gov] Carl Woese has pointed out a useful and important distinction between empirical, methodological reductionism and fundamentalist reductionism.[books.google.ro] The metabolism of proline, glutamate, serine and glutamine was found to result in relatively high rates of nitrate reduction.[ncbi.nlm.nih.gov] Consequently, a 65-kDa protein with hemolytic activity was obtained, suggesting that this protein might be a hemolysin.[ncbi.nlm.nih.gov] Alternatively, a direct pathogenic effect of the antagonistic substance on the host-tissue could be possible.[onlinelibrary.wiley.com] Septicemie a Eikenella corrodens a point de depart vesiculaire hautement probable . Médecine et Maladies Infectieuses, Vol. 17, Issue. 12, p. 746.[cambridge.org]

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