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318 Possible Causes for 9, PGP

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  • Alitretinoin

    The CYP3A4 PgP substrates of simvastatin and ciclosporin A did not affect the single or repeated dose PK of alitretinoin.[] CHEBI:50648 - 9- cis -retinoic acid Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models InChI 1S/C20H28O2/c1- 15(8- 6- 9- 16(2) 14- 19(21) 22) 11- 12- 18- 17(3)[] ,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid ChEBI (7E,9Z,11E,13E)-Retinoic acid ChEBI 9(Z)-Retinoic acid ChEBI 9-cis-Tretinoin[]

  • Vinblastine

    […] resistant cell lines was found to correlate directly with an impact on Pgp-derived efflux.[] […] button to enlarge Close Synonym: VLB; Vincaleukoblastine sulfate salt Application: An anti-mitotic agent which arrests the cell cycle in the G 2 /M-phase CAS Number: 143-67-9[] Wt 909.06 Formula C 46 H 58 N 4 O 9 .H 2 SO 4 Storage Desiccate at 4 C Purity 95% (HPLC) CAS Number 143-67-9 PubChem ID 241902 InChI Key KDQAABAKXDWYSZ-JKDPCDLQSA-N Smiles[]

  • Harpagophytum Procumbens

    Pgp activity and expression were tested by the calcein-AM test and by Western blotting, respectively.[] Compounds 1, 2, 6, 7 and 9 are known for H. procumbens; 3 and 10 were isolated the first time from H. procumbens; compounds 4, 5 and 8 are new natural products.[] Phytother Res. 2010 Sep;24(9):1365-9. doi: 10.1002/ptr.3124.[]

  • Quinacrine

    When evaluated on bidirectional assays on a Pgp overexpressing cell line, one analog was less susceptible to Pgp efflux activity compared to quinacrine.[] Abstract A library of functionalized 6-chloro-2-methoxy-(N(9)-substituted)acridin-9-amines structurally related to quinacrine were synthesized and evaluated for antiprion[] Abstract Quinacrine-the drug based on 9-aminoacridine-failed in clinical trials for prion diseases, whereas it was active in in vitro studies.[]

  • Lactobacillus Acidophilus

    Interestingly, overexpression of c-Fos or c-Jun activated Pgp promoter by nearly twofold each.[] Below are 9 ways in which Lactobacillus acidophilus may benefit your health. High cholesterol levels may increase the risk of heart disease.[] The current studies were designed to elucidate the molecular mechanisms mediating the stimulatory effects of LA CS on Pgp promoter activity.[]

  • Euphorbia

    Mechanistically, EA/EuH decreased tumor necrosis factor alpha (TNFα)-induced matrix metalloproteinase (MMP)-9 mRNA expression through the inhibition of NF-κB activity in MDA-MB[] Since J196-9-4 inhibited P-gp mediated efflux and stimulated ATP hydrolysis, J196-9-4 was a substrate of P-gp.[] (J196-9-4) could modulate multidrug resistance. Cytotoxicity assays were performed to measure the reversal efficiency of J196-9-4.[]

  • Bepridil

    MDR1/Pgp expression was positive in nine of 14 cases.[] The 9-year French experience suggests that bepridil is a safe and effective agent for treatment of angina pectoris in properly selected patients.[] Maintenance of sinus rhythm was achieved in 9 of 25 patients (36%) in the bepridil group, and in 22 of 35 patients (62%) in the RAS-I group with persistent atrial fibrillation[]

  • Atorvastatin

    Further investigation into PGP impact on HMG-CoA appears warranted.[] BACKGROUND: A Phase 2, dose-ranging study of bococizumab, a monoclonal anti-proprotein convertase subtilisin/kexin type 9 antibody, was conducted in Japanese subjects to assess[] CONCLUSIONS: PGP drug interactions with atorvastatin and other hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) may be associated with unreported risks for[]

  • Irinotecan

    Overall, the current study suggests that Pgp and cMOAT are capable of mediating the efflux of CPT-11 in vitro.[] The objective response rate and the disease control rate (DCR) were 55% (5/9) and 78% (7/9), respectively. The median progress free survival time was 8.3 months.[] Gastric Cancer. 2018 May;21(3):464-472. doi: 10.1007/s10120-017-0759-9. Epub 2017 Aug 10.[]

  • Idarubicin

    Therapeutics February 2002, 300 (2) 688-694; DOI: Abstract Little is known about cardiac uptake kinetics of idarubicin, including a possible protective role of P-glycoprotein (Pgp[] 5,12-Naphthacenedione, 9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7S,9S)- 5,12-Naphthacenedione, 9-acetyl-7-[[] Idarubicin Hydrochloride Catalogue number: I167000 Chemical name: Idarubicin Hydrochloride Synonyms: (7S,9S)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy[]

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