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48 Possible Causes for A 4, combretastatin

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  • Combretum

    Of the eight cell lines used, combretastatin A-4 showed preferential cytotoxicity for six of them.[] RESULTS: Combretum hereroense showed higher production of IL-4 at three different concentrations and a significant expression of mRNA with 4-fold amplification increase at[] Bioassay-guided fractionation of this extract yielded two known bioactive compounds, combretastatin A-1 and (-)-combretastatin, and two new bioactive glucosides, combretastatin[]

  • Thiabendazole

    Griggs J, Skepper JN, Smith GA, Brindle KM, Metcalfe JC, et al. (2002) Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4.[] Name: 2-(4-thiazolyl)benzimidazole CAS: 148-79-8;98002-42-7 Molecular Formula: C10H6N2S2 Molecular Weight: 218.298 Home CAS CAS 148 CAS 148-79-8 2-(4-thiazolyl)benzimidazole[] ; Tebuzate; 2-(1,3-thiazol-4-yl)benzimidazole; 2-(4-thiazolyl)-Benzimdazole; 2-(4-thiazolyl)-1H-Benzimidazole, ; 2-(Thiazol-4-Yl)benzimidazole; SMILES CLASSIFICATION PHYSICAL[]

  • Paclitaxel

    The biology of the combretastatins as tumour vascular targeting agents . Int. J. Exp. Pathol. 83 , 21–38 (2002).[] Approximately 4% patients, especially with high dosage, experience significant sensory and motor difficulty and decreased tendon reflex.[] Paclitaxel, 99.5 % MDL MFCD00869953 Chemical Properties Formula C 4 7 H 5 1 NO 1 4 Formula Weight 853.91 Form Crystalline solid Melting point 213 dec.[]

  • Colchicine

    […] a novel tubulin inhibitor 7a3 targeting the colchicine binding site was designed, synthesized, and optimized from a series of novel cis-restricted pyrazole analogues of combretastatin[] Responses were sustained in all but 4 patients, who relapsed.[] MCF-7TXT cells were also noted to be more sensitive to other CSBAs including 2MeOE2, ABT-751 and phosphorylated combretastatin A-4 (CA-4P).[]

  • Sulfone

    Abstract Studies examining various spacer groups that link the two aromatic rings of combretastatin A-4 (CA4) have shown that the biological activity of analogs does not require[] A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4. Eur J Med Chem 2009;44(6):2685-88. 19.[] Electronic address: [email protected] 4 Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; State Key Laboratory of[]

  • Malignant Glioma

    ) into 75:25 PLGA nanofibres [BIC and combretastatin (BICC)/PLGA].[] Bone morphogenetic protein 4 (BMP4), drives differentiation of GCSCs and thus improves therapeutic efficacy.[] Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. Alcohol X Interacts with Alcohol.[]

  • Alendronate

    KEYWORDS: alendronate; antiangiogenic; bone targeting; combretastatin A4; polymer drug conjugate[] Product Name Osteofos 70mg 4 Tablets/Pack Also known as Fosamax Active Ingredient Alendronate Sodium Manufacturer Cipla Pharmaceuticals Product Type Antiosteoporotic (bisphosphonate[] In this work, poly(oligoethylene glycol)methacrylate (POEGMA) based bone-targeting polymers bearing an antiangiogenic drug combretastatin A4 (CA4) were synthesized using free[]

  • Epithelioid Cell Sarcoma

    Synthesis and biological properties of bioreductively targeted nitrothienyl prodrugs of combretastatin A-4 . Mol. Cancer Ther. 5 , 2886–2894 (2006). 88.[] Figure 4.[] Table 4.[]

  • Etoposide

    Sackett , Podophyllotoxin, steganacin and combretastatin: Natural products that bind at the colchicine site of tubulin , Pharmacology & Therapeutics , 59 , 2 , (163) , (1993[] Pediatr Hematol Oncol. 2017 May;34(4):187-198. doi: 10.1080/08880018.2017.1360970. Epub 2017 Oct 17.[] […] in 4-week intervals.[]

  • Anthracycline

    Xiaoyan Wang, Chunlai Nie and Lijuan Chen , Discovery of a potent microtubule-targeting agent: Synthesis and biological evaluation of water-soluble amino acid prodrug of combretastatin[] ) zu erzeugen. (4) to generate hydrolyzing the protektierten 4-demethoxydaunorubicin in a basic solution to produce 4-R-substituted anthracyclines of formula (I).[] CHEBI:47898 - 4'-epidoxorubicin Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models InChI 1S/C27H29NO11/c1- 10- 22(31) 13(28) 6- 17(38- 10) 39- 15- 8- 27(36,16(30[]

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