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36 Possible Causes for ALAS1

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  • Gallbladder Carcinoma

    The recommended combinations were PPIA PUM1 ACTB for the total sample group, GAPDH PBGD ALAS1 for the gallbladder carcinoma group and PPIA PUM1 TBP for the paired normal gallbladder[ncbi.nlm.nih.gov]

  • Avascular Necrosis of the Femoral Head

    This study aimed to evaluate 12 genes (18S, GAPDH, B2M, ACTB, ALAS1, GUSB, HPRT1, PBGD, PPIA, PUM1, RPL29, and TBP) for their reliability and stability as reference sequences[ncbi.nlm.nih.gov]

  • Sideroblastic Anemia

    Glucose and heme administration decreases ALAS1 activity and provides effective therapy.[ommbid.mhmedical.com] […] more frequent in women than in men, and are often exacerbated by certain sex steroids, drugs, and diet that induce the housekeeping form of 5-aminolevulinic acid synthase (ALAS1[ommbid.mhmedical.com]

  • Rhabdomyolysis

    Here, we examined the changes with time in the gene expression of Bach1, HO-1, and δ-aminolevulinate synthase (ALAS1, a heme biosynthetic enzyme) in the rat kidney using an[ncbi.nlm.nih.gov] Following glycerol treatment, HO-1 mRNA and protein levels were significantly up-regulated, while ALAS1 mRNA expression was down-regulated, suggesting an increase in the free[ncbi.nlm.nih.gov]

  • Avascular Necrosis

    This study aimed to evaluate 12 genes (18S, GAPDH, B2M, ACTB, ALAS1, GUSB, HPRT1, PBGD, PPIA, PUM1, RPL29, and TBP) for their reliability and stability as reference sequences[ncbi.nlm.nih.gov]

  • Acute Intermittent Porphyria

    The treatment of choice is intravenous haem, which restores the deficient regulatory haem pool of the liver and represses ALAS1.[ncbi.nlm.nih.gov] […] individuals experience life-threatening acute neurovisceral attacks that are precipitated by factors that induce the hepatic expression of 5-aminolevulinic acid synthase 1 (ALAS1[ncbi.nlm.nih.gov] Emerging therapies including replacement enzyme therapy or gene therapies (HMBS-gene transfer and ALAS1-gene expression inhibition) are being developed to improve quality[ncbi.nlm.nih.gov]

  • Acute Hepatic Porphyria

    Inhibition of ALAS1 is known to reduce the accumulation of heme intermediates that cause the clinical manifestations of AIP.[spjnews.com] ALN-AS1 is a small interfering RNA therapy that decreases the upregulation of ALAS1 mRNA.[hematologyandoncology.net] […] company also announced initial results from an open-label extension or OLE study with givosiran, an investigational RNAi therapeutic targeting aminolevulinic acid synthase 1 (ALAS1[markets.businessinsider.com]

  • Porphyria

    ALN-AS1 is a small interfering RNA therapy that decreases the upregulation of ALAS1 mRNA.[hematologyandoncology.net] In the liver, “free” heme regulates the synthesis and mitochondrial translocation of the housekeeping form of ALA-synthase, ALAS1. 6 Heme represses the synthesis of the ALAS1[bloodjournal.org] Enter givosiran, a gene-silencing drug designed to switch off the aminolevulinic acid synthase 1 (ALAS1) gene.[fiercebiotech.com]

  • X-Linked Sideroblastic Anemia and Ataxia

    Whereas, ALAS2 is restricted to fetal liver and adult bone marrow, ALAS1 is expressed in all cells.[themedicalbiochemistrypage.org] Glucose and heme administration decreases ALAS1 activity and provides effective therapy.[ommbid.mhmedical.com] Other interactions of ALAS2 Using these different cDNAs, the human ALAS housekeeping gene ( ALAS1 ) and the human erythroid-specific ( ALAS2 ) gene have been localized to[wikigenes.org]

  • Autosomal Recessive Sideroblastic Anemia

    Downregulation of ALAS1 by nicarbazin treatment underlies the reduced synthesis of protoporphyrin IX in shell gland of laying hens Sami Samiullah , Juliet Roberts & Shu-Biao[nature.com] Glucose and heme administration decreases ALAS1 activity and provides effective therapy.[ommbid.mhmedical.com] […] more frequent in women than in men, and are often exacerbated by certain sex steroids, drugs, and diet that induce the housekeeping form of 5-aminolevulinic acid synthase (ALAS1[ommbid.mhmedical.com]

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