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627 Possible Causes for AND, METAPLASIA, Myelofibrosis, MYELOID

  • Myelofibrosis

    […] multipotential cell; the major myeloid lineages are usually involved to some extent in clonal myeloid diseases.[doi.org] PMID 15388582 MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.[atlasgeneticsoncology.org] Idiopathic myelofibrosis; Myeloid metaplasia; Agnogenic myeloid metaplasia; Primary myelofibrosis; Secondary myelofibrosis; Bone marrow - myelofibrosis Long NM, Kavanagh EC[nlm.nih.gov] Myelofibrosis with myeloid metaplasia is classified broadly as a chronic myeloid disorder and, more specifically, as a chronic myeloproliferative disease 1 (Figure 1).[nejm.org]

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  • Myeloid Metaplasia

    Subject: Chromosome 99; Leukemia Section; MPD (class disease); Agnogenic myeloid metaplasia; JAK2 protein, human; Primary Myelofibrosis Publisher: Jean-Loup Huret (Editor-in-Chief[documents.irevues.inist.fr] Abstract Agnogenic myeloid metaplasia is a chronic myeloproliferative disorder characterized by splenomegaly, leukoerythroblastosis, extramedullary hematopoiesis, teardrop-shaped[ncbi.nlm.nih.gov] […] procedures, such as sonography, mammography, fine needle aspiration biopsy and surgical excision with histological examination of removed tissue in obtaining the diagnosis of myeloid[ncbi.nlm.nih.gov] Some patients with ET may also develop polycythemia vera (PV) and without a history of phlebotomies patients with primary myelofibrosis (PMF) are indistinguishable from those[ncbi.nlm.nih.gov]

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  • Secondary Myelofibrosis

    Serum PH activity was measured in patients with primary myelofibrosis (agnogenic myeloid metaplasia and myelofibrosis with prior history of polycythaemia vera), in patients[ncbi.nlm.nih.gov] These findings are rare and myeloid metaplasia with striking extramedullary hematopoiesis causing massive splenomegaly and mimicking agnogenic myeloid metaplasia is seldom[ncbi.nlm.nih.gov] Prognostic variables in sMF are not as well defined as they are for de novo myelofibrosis with myeloid metaplasia (MMM), which is also known as agnogenic myeloid metaplasia[ncbi.nlm.nih.gov] Although extramedullary hematopoiesis has been generally observed in primary myelofibrosis, in this case it was seen in myelofibrosis secondary to polycythemia vera.[ncbi.nlm.nih.gov]

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  • Primary Myelofibrosis

    PURPOSE: To report ocular manifestations of idiopathic primary myelofibrosis in a patient with relapsed primary myelofibrosis. METHODS: Observational case report.[ncbi.nlm.nih.gov] Myeloid sarcoma (MyS) is defined as an extramedullary tumor-forming neoplasm consisting of immature myeloid cells with/without maturation.[ncbi.nlm.nih.gov] Bone marrow specimens from 11 patients with myelofibrosis with myeloid metaplasia (MMM) and seven normal controls were studied immunohistochemically to determine expression[ncbi.nlm.nih.gov] Splenectomy and risk of blast transformation in myelofibrosis with myeloid metaplasia. Italian Cooperative Study Group on Myeloid with Myeloid Metaplasia.[doi.org]

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  • Myeloproliferative Disease

    Massachusetts, USA. [email protected] Abstract Oncogenic N-RAS and K-RAS mutations are among the most frequently detected genetic alterations in patients with acute myeloid[ncbi.nlm.nih.gov] […] myeloproliferative disorders comprise a group of related diseases, including polycythemia vera, essential thrombocythemia, chronic myelogenous leukemia, myelofibrosis, and myeloid metaplasia[ncbi.nlm.nih.gov] , including primary myelofibrosis, post–polycythemia vera myelofibrosis, and post–essential thrombocythemia myelofibrosis. 14 Two phase III trials demonstrated significant[ajmc.com] Cytogenetically normal acute myeloid leukemia (CN-AML) represents nearly 50% of human AML.[ncbi.nlm.nih.gov]

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  • Thrombocythemia 2

    Myelofibrosis A Phase 2 Study of the Safety, Tolerability, and Efficacy of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis The purpose of this study[pvreporter.com] PubMed/NCBI 17 Pagnano KBB, Almeida D, Delamain MT, De Souza AC and Lorand-Metze I: JAK2 V617F mutation evaluation of chronic myeloid leukemia and acute myeloid leukemia.[spandidos-publications.com] There are four main types of MPDs, namely, Polycythemia Vera (PV), Essential thrombocythemia (ET), Myeloid metaplasia (MMM), and Chronic myelomonocytic leukemia (CMML).[oatext.com] Polycythemia vera, essential thrombocythemia, and primary myelofibrosis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine . 25th ed.[medlineplus.gov]

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  • Unclassified Chronic Myeloproliferative Disease

    MPN are subclassified into eight separate entities: chronic myelogenous leukemia, polycythemia vera, essential thrombocythemia, primary myelofibrosis, systemic mastocytosis[leukemia-net.org] PMID 12542482 The chronic myeloid leukaemias: guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia.[atlasgeneticsoncology.org] .- ) Type 1 Excludes acute myelofibrosis ( C94.4- ) idiopathic myelofibrosis ( D47.1 ) leukoerythroblastic anemia ( D61.82 ) myelofibrosis with myeloid metaplasia ( D47.4[icd10data.com] Chronic MPD Polycythemia vera, agnogenic myeloid metaplasia, primary thrombocythemia, chronic myelogenous leukemia–Philadelphia chromosome positive or negative, chronic monocytic[medical-dictionary.thefreedictionary.com]

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  • Post-Polycythemia Vera Myelofibrosis

    Because ASXL1 lesions have been increasingly identified in myeloid neoplasms, we examined the relationships of ASXL1 mutation or deletion to both clinical phenotype and associated[ncbi.nlm.nih.gov] (AMM), myelofibrosis with myeloid metaplasia (MMM), and many other names in the hematologic literature.[vivo.med.cornell.edu] PV belongs to the group of "BCR-ABL1-negative" myeloproliferative diseases (MPNs), together with essential thrombocythemia and primary myelofibrosis, which turned the attention[symptoma.com] Chr12 abnormalities did not significantly correlate with JAK2 status, progression to acute myeloid leukemia, or survival, however patients with 12q24 abnormalities trended[ncbi.nlm.nih.gov]

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  • Thrombocytosis

    We report two cases of chronic myeloid leukaemia (CML) with extreme thrombocytosis.[ncbi.nlm.nih.gov] […] thrombocytosis (ET) falls under the umbrella of myeloproliferative disorders, which also includes chronic myelogenous leukemia, polycythemia vera, and myelofibrosis with myeloid metaplasia[ncbi.nlm.nih.gov] Myelofibrosis/drug therapy Primary Myelofibrosis/genetics* Primary Myelofibrosis/pathology Pyrazoles/pharmacology Pyrrolidines/pharmacology Receptors, Thrombopoietin/genetics[ncbi.nlm.nih.gov] We present an unusual case study on acute myeloid leukemia associated with t(1;3) and extreme thrombocytosis, along with a thorough review on relevant literature of t(1;3)[ncbi.nlm.nih.gov]

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  • Extramedullary Hematopoiesis

    A 63-year-old patient with primary myelofibrosis underwent kidney biopsy to investigate nephrotic-range proteinuria and reduced kidney function.[ncbi.nlm.nih.gov] The present case report describes a patient with the diagnosis of atypical chronic myeloid leukemia and myelofibrosis who subsequently developed EMH of the pericardium with[ncbi.nlm.nih.gov] We describe a case of follicular adenoma with histologically proven osseous metaplasia and mature bone formation with EMH in a middle- aged woman, which, to our knowledge,[ncbi.nlm.nih.gov] Megakaryocytes were immunoreactive with factor VIII, erythroid elements with Glycophorin and myeloid precursors with myeloperoxidase.[ncbi.nlm.nih.gov]

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