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58 Possible Causes for ATPase, activity, peroxisome assembly

  • Zellweger Syndrome

    The second enzymic activity was associated with peroxisomes and acted only on the 24R,25R-isomer, in which the 24-hydroxy group possesses the D-configuration.[ncbi.nlm.nih.gov] Abstract The primary defect arising from Zellweger syndrome appears to be linked to impaired assembly of peroxisomes.[ncbi.nlm.nih.gov] Abstract Peroxisomal matrix protein import requires the action of two AAA ATPases, PEX1 and PEX6.[ncbi.nlm.nih.gov]

  • Peroxisomal Disease

    We have restored SIRT1 activity using a dual strategy of resveratrol treatment or by the moderate transgenic overexpression of SIRT1 in a X-ALD mouse model.[ncbi.nlm.nih.gov] A defect in a peroxisomal VLCFA CoA synthetase or ligase has been reported for these patients, but assembly of their peroxisomes is apparently normal.[ncbi.nlm.nih.gov] […] in PEX5, which encodes the PTS1 receptor, PEX2 and PEX12, which encode two zinc-binding integral membrane proteins; and PEX6, which encodes vesicle-associated cytosolic ATPase[ncbi.nlm.nih.gov]

  • Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum

    To identify drugs that help recover peroxisome function a group of scientists developed a laboratory-based research test aimed at reviewing the activity of the large number[clinicaltrials.gov] For two such patients, we conducted cell fusion complementation analyses to identify the defective gene responsible for aberrant peroxisome assembly.[ncbi.nlm.nih.gov] It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.[genecards.org]

  • Telmisartan

    Our results indicate that telmisartan can be considered as a novel AMPK activator, suppressing microglia activation by promoting M2 polarization.[ncbi.nlm.nih.gov] Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ. Nature . 1998; 395 : 137–143.[doi.org] Angiotensin II stimulation of Na /K( )ATPase activity and cell growth by calcium-independent pathway in MCF-7 breast cancer cells .[doi.org]

  • Rhizomelic Chondrodysplasia Punctata Type 2

    , alkyl-dihydroxyacetonephosphate synthase (alkyl-DHAP synthase) activity, and peroxisomal 3-ketoacyl-CoA thiolase protein were normal.[ncbi.nlm.nih.gov] Human peroxisome assembly factor-2 (PAF-2): A gene responsible for Group C peroxisome biogenesis disorder in humans. Am. J. Hum.[nature.com] […] annotations that may be applicable to E71.540 : E00-E89 2019 ICD-10-CM Range E00-E89 Endocrine, nutritional and metabolic diseases Note All neoplasms, whether functionally active[icd10data.com]

  • Saccharomyces Cerevisiae

    Because sulfate mimics the chemistry of a phosphate group, this structural data suggested that this groove represents the phosphoryl transfer active site.[ncbi.nlm.nih.gov] […] organization and biogenesis 8.91E-06 BP Shorter 39 Chromatin assembly/disassembly 1.43E-05 BP Shorter 24 As shown in Table 4 , there were a number of functional classes of[genomebiology.biomedcentral.com] A C-terminal deletion mutant of Ctf18 (ctf18(ΔC) ) exhibited the same high sensitivity to hydroxyurea as the complete deletion strain (ctf18Δ) or ATPase-deficient mutant ([ncbi.nlm.nih.gov]

  • Infantile Refsum Disease

    Furthermore, beta-oxidation of VLCFA is re-established in these selected cells as well as dihydroxyacetone phosphate acyltransferase activity.[ncbi.nlm.nih.gov] Infantile Refsum disease is an autosomal recessive disorder caused by mutations in genes that encode peroxins, proteins required for normal peroxisome assembly.[en.wikipedia.org] Abstract Peroxisomal matrix protein import requires the action of two AAA ATPases, PEX1 and PEX6.[ncbi.nlm.nih.gov]

  • Refsum Disease

    Furthermore, beta-oxidation of VLCFA is re-established in these selected cells as well as dihydroxyacetone phosphate acyltransferase activity.[ncbi.nlm.nih.gov] This category is inherited as an autosomal recessive trait and is characterized by altered peroxisome assembly, resulting in multiple peroxisome enzyme deficiencies, complex[emedicine.com] The activities of complexes I, II, I-III and II-III and Na( ), K( )- ATPase were markedly inhibited (65-85%) in a dose-dependent manner by Phyt.[ncbi.nlm.nih.gov]

  • Neonatal Adrenoleukodystrophy

    ) and (2) X-linked childhood adrenoleukodystrophy (deficiency of activation of lignoceric acid).[ncbi.nlm.nih.gov] […] that are critical for peroxisome assembly and biogenesis and 7 genes that encode single enzymes for peroxisome functions.[bcm.edu] The PEX1 gene encodes a protein that is a member of the AAA-type ATPases (AAA: A TPases A ssociated with diverse cellular A ctivities).[themedicalbiochemistrypage.org]

  • Dermatomyositis

    Although serum ferritin level is known to reflect interstitial lung disease activity, there are few case reports describing this association.[ncbi.nlm.nih.gov] […] on the mitochondrial and peroxisomal membranes.[clinicalmolecularallergy.biomedcentral.com] (Arrow; Right) COX stain Perifascicular atrophy: ATPase pH 9.4 stain ATPase pH 9.4 stain Perifascicular atrophy is often especially obvious on ATPase stains.[neuromuscular.wustl.edu]