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2,347 Possible Causes for Acetylcholine

  • Dementia

    […] manifestations of Alzheimer's disease is to enhance cholinergic neurotransmission in relevant parts of the brain by the use of cholinesterase inhibitors to delay the breakdown of acetylcholine[] Cholinesterase is an enzyme that breaks down a chemical in the brain called acetylcholine. Acetylcholine acts as an important messaging system in the brain.[] These drugs inhibit acetylcholinesterase, increasing the acetylcholine level in the brain.[]

  • Smoking

    Varenicline (Champix , Chantix ) is a partial agonist of the α4β2 nicotinic acetylcholine receptor (nAChR) and a full agonist of the α7 nAChR.[] Two mechanisms underlie smoking cessation efficacies of α4β2* nicotinic acetylcholine receptor (nAChR) agonists: a "nicotine-like" agonist activity reduces craving by substituting[]

  • Tobacco

    The nicotinic acetylcholine receptor partial agonist varenicline has been shown to be effective in the treatment of tobacco dependence, but has been reported to induce exacerbations[] […] receptor modulators nAChRs Agonists (and PAMs ) 5-HIAA A-84,543 A-366,833 A-582,941 A-867,744 ABT-202 ABT-418 ABT-560 ABT-894 Acetylcholine Altinicline Anabasine Anatoxin-a[] […] receptor modulators • Acetylcholine metabolism/transport modulators v t e TRP channel modulators TRPA Activators 4-Hydroxynonenal 4-Oxo-2-nonenal 4,5-EET 12S-HpETE 15-Deoxy-Δ[]

  • Sclerosteosis Type 2

    […] signaling pathway via nicotinic acetylcholine receptor acetylcholine metabolic pathway Ache , Chat acetylcholine signaling pathway via muscarinic acetylcholine receptor Ache[] Genes in Pathway: show annotations for term's descendants view all columns Sort by: acetylcholine signaling pathway via nicotinic acetylcholine receptor G Ache acetylcholinesterase[] Pathway Gene Annotations Disease Annotations Associated with Genes in the acetylcholine signaling pathway via nicotinic acetylcholine receptor Abnormal Reflexes Chrnb2 acute[]

  • Cerebrovascular Insufficiency

    The M(5) muscarinic acetylcholine receptor is known to play a crucial role in mediating acetylcholine dependent dilation of cerebral blood vessels.[] In apoE4 mice, the increase in CBF produced by whisker stimulation (WS) or by topical application of the endothelium-dependent vasodilator acetylcholine (ACh) was attenuated[] Previously, we reported that male M(5) muscarinic acetylcholine knockout mice (M5R(-/-) mice) suffer from a constitutive constriction of cerebral arteries, reduced cerebral[]

  • High Calcium Diet

    DOC augmented in vitro contractions of aortic and mesenteric arterial rings induced by noradrenaline and impaired relaxations in reponse to nitroprusside and acetylcholine[] In the DOC calcium group vascular contractions did not differ from control values, but the relaxations caused by nitroprusside and acetylcholine were augmented in the mesenteric[]

  • Hip Dislocation

    Botulinum toxin decreases muscle activity by blocking the release of acetylcholine at the neuromuscular junction, thereby rendering the muscle unable to contract for up to[]

  • Perilla

    They were less inhibitory against other enzymes such as alpha-secretase (TACE), acetylcholine esterase (AchE), chymotrypsin, and elastase, indicating that they were relatively[] One of the critical features of Alzheimer's disease is cognitive dysfunction, which is, in part, due to decreases in acetylcholine (ACh).[]

  • Nizatidine

    In addition to its acid-suppressing effect, the H2RA nizatidine also has a prokinetic action by suppressing acetylcholine esterase.[] This prokinetic activity occurs through noncompetitive inhibition of acetylcholine; this inhibition approximates the inhibition caused by neostigmine.[] Both nizatidine and cisapride have been reported to increase acetylcholine concentrations in the cholinergic system.[]

  • Desmoplastic Small Round Cell Tumor

    Ongoing research in similar neurocrest-derived neoplasms has implicated both the muscarinic acetylcholine receptor (mAChR) and nicotinic acetylcholine receptor (nAChR) in[] Acetylcholine has been reported to impart a modulatory effect on chemotaxis and proliferation, an effect ameliorated by anticholinergic drugs.[]

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