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572 Possible Causes for Acid, Orotic

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  • Coma

    Abstract Hyperammonaemic encephalopathy is a rare and potentially fatal complication of valproic acid treatment.[] Measurement of plasma ammonia concentration, followed by measurement of plasma amino acid and urine orotic acid levels allowed to diagnose the OTC deficit, lately confirmed[] KEYWORDS: drug concentration; hypoglycemic coma; succinic acid cibenzoline[]

  • Streptozocin

    […] reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid[] Nucleotide and RNA metabolism was studied in the renal cortex after infusion of radio-labeled orotate or adenine.[] Abstract In this study, the effect and mechanism of a series of ursolic acid (UA) derivatives on glucose uptake were investigated in a Caco-2 cells model.[]

  • Alkaptonuria

    acid excretion.[] BACKGROUND: Urinary homovanillic acid (HVA)/vanillylmandelic acid (VMA), orotic acid (OA), and homogentisic acid (HGA) are diagnostic biomarkers of neuroblastoma, ornithine[] acid, 91-104% for tyrosine and 88-103% for nitisinone.[]

  • Intrahepatic Cholestasis

    Ursodeoxycholic acid has been proposed as a treatment alternative, but its use remains controversial.[] […] hypoproteinaemia, abnormal liver enzymes, prolonged coagulation profile, hyperammonaemia, hypergalactosaemia, multiple aminoacidaemia, elevated α-feto protein and urinary orotic[] KEYWORDS: bile acid metabolism; bile salts; clinical studies; cytochrome P450; diseases; liver; progressive familial intrahepatic cholestasis[]

  • Ornithine Transcarbamylase Deficiency

    The amino acid profile in the 10 patients showed increases in glutamine, proline, lysine, valine and methionine, and decreases in serine, ornithine and arginine.[] BACKGROUND: Orotic acid (OA) is the key parameter in the detection of ornithine transcarbamylase deficiency (OTC-D).[] Five months after discharge, urinary uracil concentration remained elevated despite normalized orotic acid concentration.[]

  • Hypercalcemia

    Furthermore, disease-modifying effects of zoledronic acid in sarcoidosis should be investigated.[] If you're unable to meet your calcium requirements through food sources, I advise supplementing with calcium orotate .[] Calcium levels should be monitored at days 1, 7, and 14 of each course of retinoic acid.[]

  • Hereditary Orotic Aciduria without Megaloblastic Anemia

    […] yielded increased levels of both orotic acid and oritidine.[] Orotic acid is a heterocyclic compound and an acid; it is also known as pyrimidinecarboxylic acid. Wikipedia ( 6 entries) edit.[] For comparison: Patients diagnosed with classical orotic aciduria had orotate-to-orotidine ratios of 29-590.[]

  • Homocystinuria

    The accumulation of toxic metabolites in organic acidurias, respiratory chain, and fatty acid oxidation disorders inhibits mitochondrial enzymes and processes resulting in[] […] procedure, which consists of urease treatment, stable isotope dilution and GC-MS, enables a simultaneous quantification of methionine, homocystine, cystine, methylmalonate, orotate[] Homocysteine levels in the serum and urine are difficult to estimate because the amino acid is usually bound to other proteins or amino acids with disulfide bonds.[]

  • Lysinuric Protein Intolerance

    Furthermore, of these metabolites, myo-inositol, threonic acid, 2,5-furandicarboxylic acid, galactaric acid, 4-hydroxyphenylacetic acid, indole-3-acetic acid and beta-aminoisobutyric[] All other subjects remained asymptomatic and showed no change in plasma ammonia or urinary orotic acid excretion.[] […] high plasma Citr, Ala, Gly, Glu, Ser levels, as well as citrullinuria, lysinuria, glutaminuria, alaninuria, argininuria, prolinuria, hydroxyprolinuria, ornithinuria, and orotic[]

  • Flumazenil

    […] hastening of emergence from general anesthesia has largely focused on activating subcortical monoaminergic networks, with little attention on antagonizing the γ-aminobutyric acid[] Abnormally high levels of orotic acid were found in serum and urine, confirming the diagnosis of ornithine transcarbamylase deficiency.[] Flumazenil Catalogue number: F500450 Chemical name: Flumazenil Synonyms: 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Ethyl Ester[]

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