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5,028 Possible Causes for Activity, Alpha, Peroxisome, Proliferator Activated, Receptor, [MoA]

  • Troglitazone

    Abstract Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma have been shown to induce terminal differentiation of normal preadipocytes[ncbi.nlm.nih.gov] PPAR gamma coactivator-1 alpha (PGC-1 alpha) functioning as an inverse agonist.[ncbi.nlm.nih.gov] […] in T-lymphocyte activation.[ncbi.nlm.nih.gov] Abstract The role of the peroxisome proliferator-activated receptor-γ (PPARγ) in cell differentiation, cell cycle arrest and apoptosis has attracted increasing attention.[ncbi.nlm.nih.gov] In the present study, we showed that co-treatment with troglitazone (TGZ), a synthetic ligand of peroxisome proliferator-activated receptor γ (PPARγ), and TRAIL synergistically[ncbi.nlm.nih.gov] The peroxisome proliferator-activated receptor-gamma (PPARgamma) is a related nuclear hormone receptor that can be activated by its ligands, including the thiazolidinediones[ncbi.nlm.nih.gov]

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  • Bezafibrate

    Author information 1 Department of Nutrition and Food, Harbin Medical University, Heilongjiang, China. [email protected] Abstract Fibrates, the ligands of peroxisome proliferator-activated[ncbi.nlm.nih.gov] However, bezafibrate has a unique characteristic profile of action since it activates all three PPAR subtypes (alpha, gamma and delta) at comparable doses.[ncbi.nlm.nih.gov] Receptors PPAR alpha RNA, Messenger Receptors, IgG Bezafibrate[ncbi.nlm.nih.gov] The goal of this study was to evaluate the effect of the peroxisome proliferator-activated receptor ligand bezafibrate on the progression of impaired fasting glucose phase[ncbi.nlm.nih.gov] Among these fibrates, the binding activity of fenofibrate to PPAR-alpha is stronger than that of bezafibrate.[ncbi.nlm.nih.gov] Nuclear peroxisome proliferator-activated receptors (PPAR), which play a central role in lipid and glucose metabolism, had been hypothesized as being involved in colon cancerogenesis[ncbi.nlm.nih.gov]

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  • Telmisartan

    Peroxisome proliferator-activated receptor δ (PPARδ), a versatile regulator of metabolic homeostasis, may be a potential therapeutic target.[ncbi.nlm.nih.gov] Plasma protein binding is over 99.5%, mainly to albumin and alpha-1-acid glycoprotein.[en.wikipedia.org] Our results indicate that telmisartan can be considered as a novel AMPK activator, suppressing microglia activation by promoting M2 polarization.[ncbi.nlm.nih.gov] In humans, mutations in the peroxisome proliferator-activated receptor-gamma (PPARgamma) have been reported to cause the full-blown metabolic syndrome, and drugs that activate[ncbi.nlm.nih.gov] Effect of telmisartan on levels of IL-1, TNF-alpha, down-regulated COX-2, MMP-2, MMP-9 and RANKL/RANK in an experimental periodontitis model .[doi.org] Peroxisome proliferator-activated receptor-δ (PPARδ) expression by HUVECs exposed to Hcy with or without telmisartan pretreatment was analyzed by RT-PCR and western blotting[ncbi.nlm.nih.gov]

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  • Clofibrate

    Clofibrate treatment reduced the proliferation of breast cancer cells probably by inhibiting NF-κB and ERK1/2 activation, reducing cyclinD1, cyclinA, cyclinE, and inducing[ncbi.nlm.nih.gov] -(4-chlorophenoxy)-2-methylpropanoate 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester ChemIDplus 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester ChemIDplus alpha[ebi.ac.uk] Liver biopsies were taken after 2, 4, and 7 yr, to follow the peroxisomal response.[ncbi.nlm.nih.gov] Abstract The NADP -dependent dehydrogenase activity of a predominant isoenzyme of human liver 3alpha-hydroxysteroid dehydrogenase was activated by antihyperlipidemic drugs[ncbi.nlm.nih.gov] This increased binding was due to an increased affinity without a change in the number of insulin receptors.[ncbi.nlm.nih.gov] […] category: 2183 ATC code: C10AB01 Chemical structure group: DG00358 Product (DG00358): D00279 JP Efficacy Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated[kegg.jp]

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  • Rosiglitazone

    Abstract Anti-inflammatory effects of peroxisome proliferator-activated receptor gamma (PPRAγ) ligands are thought to be largely due to PPARγ-mediated transrepression.[ncbi.nlm.nih.gov] Similar phenomena were found on immunofluorescence microscopy of alpha-smooth muscle actin.[ncbi.nlm.nih.gov] Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the large nuclear hormone receptor transcription factor superfamily, and has been recently implicated[ncbi.nlm.nih.gov] Rosiglitazone (RSG), a thiazolidinedione ligand of the peroxisome proliferatoractivated receptor (PPAR) γ, has been found to inhibit proliferation, induce apoptosis, suppress[ncbi.nlm.nih.gov] NFkappaB-binding activity and plasma MCP-1, CRP, SAA, and TNF-alpha did not change in the obese and obese diabetic control groups.[ncbi.nlm.nih.gov] Peroxisome proliferator-activated receptor (PPAR)γ activation, through rosiglitazone treatment, reduced the rate of α-GalCer-induced late PTB and improved neonatal survival[ncbi.nlm.nih.gov]

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  • Pioglitazone

    Abstract Pioglitazone (PGZ), a peroxisome proliferator-activated receptor γ agonist, which is known as a type 2 diabetes drug, inhibits cell proliferation in various cancer[ncbi.nlm.nih.gov] (TNF alpha) and remodelling of adipose tissue.[ncbi.nlm.nih.gov] Thus, pioglitazone can increase catalase activity by changing the BLC structure. Copyright 2017 John Wiley & Sons, Ltd.[ncbi.nlm.nih.gov] Abstract The peroxisome proliferator-activated receptor gamma (PPAR γ) agonists have been reported to have antiproliferative and tumor-suppressive effects.[ncbi.nlm.nih.gov] We used 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) in a human model of lung inflammation to assess whether pioglitazone, a peroxisome proliferator-activated[ncbi.nlm.nih.gov] No significant change was found for GLP-1 agonists, DPP-4 inhibitors, sulphonylureas or alpha-glucosidase inhibitors.[ncbi.nlm.nih.gov]

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  • Familial Partial Lipodystrophy

    We studied peroxisome proliferator-activated receptor-gamma (PPARgamma) gene as a candidate gene in seven FPL patients who did not appear to have Dunnigan variety.[ncbi.nlm.nih.gov] METHODS: Plasma levels of adiponectin, leptin, resistin, IL-1beta, IL-6 and TNF-alpha in 30 subjects (ten patients, 20 controls) were correlated with indices of metabolic[ncbi.nlm.nih.gov] […] partial lipodystrophy (Dunnigan) type 3 (FPLD3, Mendelian Inheritance in Man [MIM] 604367) results from heterozygous mutations in PPARG encoding peroxisomal proliferator-activated[ncbi.nlm.nih.gov] The gene encoding retinoic acid receptor B (RARB) showed a higher methylation in all six patients with FPLD2 when compared with the progeria patients with other LMNA mutations[ncbi.nlm.nih.gov] activator receptor -γ (PPARG) mutation with those of a cluster of patients with familial partial lipodystrophy with classic codon 482 Lamin A/C (LMNA) mutations.[ncbi.nlm.nih.gov] CONTEXT: Familial partial lipodystrophy (FPLD) results from coding sequence mutations either in LMNA, encoding nuclear lamin A/C, or in PPARG, encoding peroxisome proliferator-activated[ncbi.nlm.nih.gov]

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  • Retinoid

    Vitamin D Receptor (VDR), Retinoid X Receptor (RXR) and Peroxisome Proliferator-activated Receptor γ (PPARγ) are known to interact with TRs by forming functional heterodimers[ncbi.nlm.nih.gov] KEYWORDS: AKT; Cancer; Derivatives; Triptolide; Truncated retinoic X receptor-alpha[ncbi.nlm.nih.gov] However, the active conformation of HX531 for RXRs is not well established.[ncbi.nlm.nih.gov] Abstract The promiscuous protein retinoid X receptor (RXR) displays essential allosteric regulation of several members in the nuclear hormone receptor superfamily via heterodimerization[ncbi.nlm.nih.gov] TRETINOIN All-trans-retinoic acid  1st retinoid introduced into clinical use – nearly 4 decades ago, for topical Rx of acne vulgaris MOA :  By reducing microcomedone formation[de.slideshare.net] Abstract Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent transcription factor that plays an important role in regulating glucose metabolism.[ncbi.nlm.nih.gov]

  • Irbesartan

    Activation of renal peroxisome proliferator-activated receptor α (PPARα) is renoprotective, but there is no safe PPARα activator for patients with chronic kidney disease ([ncbi.nlm.nih.gov] […] antioxidant enzymes, transforming growth factor beta 1 (TGF-β1), nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 (Nrf2/HO-1) content, tumor necrosis factor alpha[ncbi.nlm.nih.gov] The complex exerted anticancer behavior (at 100 μM) improving the activity of the ligand.[ncbi.nlm.nih.gov] Three angiotensin receptor blockers (ARBs), telmisartan, irbesartan and candesartan, inhibit the expression of the receptor for advanced glycation end-products (RAGE), which[ncbi.nlm.nih.gov] CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II ANTAGONISTS, COMBINATIONS Angiotensin II antagonists and calcium channel blockers FDA MoA[drugcentral.org] Abstract Irbesartan, an angiotensin II receptor blocker (ARB), acts as a selective PPAR-γ (peroxisome proliferator-activated receptor-γ) modulator, and thus may have anti-inflammatory[ncbi.nlm.nih.gov]

  • Refsum Disease

    It has been proposed that the disease complex in RD is in part due to the high affinity of phytanic acid for retinoid X receptors and peroxisome proliferator-activated receptors[ncbi.nlm.nih.gov] The phytanoyl-CoA ligase, the first enzyme in the alpha-oxidation pathway, had activity similar to that in peroxisomes from control (9.86 /- 0.09 nmol/h per mg protein) and[ncbi.nlm.nih.gov] […] and hence to a generalized loss of peroxisomal functions.[ncbi.nlm.nih.gov] Furthermore, beta-oxidation of VLCFA is re-established in these selected cells as well as dihydroxyacetone phosphate acyltransferase activity.[ncbi.nlm.nih.gov] Here, we studied the ability of phytanic acid and pristanic acid to activate the free fatty acid receptor GPR40, a G-protein-coupled receptor, which was described to be involved[ncbi.nlm.nih.gov] […] carnitine acetyltransferase; CYP, cytochrome P450; ER, endoplasmic reticulum; FALDH, fatty aldehyde dehydrogenase; FATP, fatty acid transport protein; PPARα, peroxisome-proliferator-activated[biochemsoctrans.org]

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