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3,793 Possible Causes for Activity, Gamma, Peroxisome, Proliferator Activated, Receptor, [MoA]

Did you mean: Activity, gumma, Peroxisome, Proliferator Activated, Receptor, [MoA]

  • Uterine Leiomyosarcoma

    The peroxisome proliferator-activated receptor γ (PPARγ) agonists, thiazolidinediones, including pioglitazone (PIO) exhibit anti-tumour activities in cancer cells.[ncbi.nlm.nih.gov] Gamma-glutamyltransferase (GGT) is an established marker for proliferative/apoptotic balance and has been associated with cancer risk and prognosis.[ncbi.nlm.nih.gov] Leiomyomata and uterine leiomyosarcomas share some common features, and they both often express progesterone receptors.[ncbi.nlm.nih.gov] Adesiyun AG, Samaila MOA. Leiomyosarcoma uteri in a white woman. Ann Afr Med 2010; 9:35-38. Oliva E. Pure mesenchymal and mixed Müllerian tumors of the uterus.[clinicalcases.eu] GGT: Gamma-glutamyltransferase.[nature.com] Protein expression of estrogen receptor (ER) and progesterone receptor (PR) by immunohistochemistry was studied in tissue microarrays from 294 patients diagnosed with uterine[ncbi.nlm.nih.gov]

  • Arsenical

    […] cytochrome c oxidase (Complex IV), measured for mitochondrial DNA (mtDNA) copy number and the expression levels of mitochondrial biogenesis-related genes, including peroxisome proliferator-activated[ncbi.nlm.nih.gov] Darinaparsin has significant activity in a broad spectrum of hematologic and solid tumors in preclinical models.[ncbi.nlm.nih.gov] The molecular bases of immunosuppression by arsenic in lymphocytes may include chromosomal and DNA abnormalities, decreased T-cell receptor activation, and the cellular status[ncbi.nlm.nih.gov] Scientific Peer Review The 2009 Agreement in Principle provided for a scientific peer review of the carcinogenic mode of action (MOA) of inorganic arsenic before the final[epa.gov] Imiquimod cream is an immune stimulator that is believed to cause an upregulation of pro-inflammatory cytokines, through Toll-like receptor 7, resulting in cellular apoptosis[clinicaladvisor.com] We present data herein that suggest that WNT5A is transcriptionally activated during arsenical-induced malignant transformation.[ncbi.nlm.nih.gov]

  • Sambucus

    T2D is caused by a combination of insulin resistance and beta-cell failure and can be treated with insulin sensitizing drugs that target the nuclear receptor peroxisome proliferator-activated[ncbi.nlm.nih.gov] S. ebulus extract at the concentration of 100 mg/ml for 60 minutes had the most anti-giardial activity (78 4%) than other concentrations.[ncbi.nlm.nih.gov] Sambucus nigra lectin has high affinity for SA-α-2,6-Gal receptors.[ncbi.nlm.nih.gov] Therefore, the present study suggests that lariciresinol possesses fungicidal activities by disrupting the fungal plasma membrane and therapeutic potential as a novel antifungal[ncbi.nlm.nih.gov] Up to now they have been conjugated with either transferrin or anti-CD105 to target either transferrin receptor- or endoglin-overexpressing cells, respectively.[ncbi.nlm.nih.gov] T2D is caused by a combination of insulin resistance and beta-cell failure and can be treated with insulin sensitizing drugs that target the nuclear receptor peroxisome proliferator-activated[ncbi.nlm.nih.gov]

    Missing: [MoA]
  • Cachexia

    The reduction in oxidative capacity involves AMP-activated protein kinase and peroxisome proliferator-activated receptor gamma coactivator 1α dysregulation.[ncbi.nlm.nih.gov] […] nuclear gene encoding for thymidine phosphorylase (ECGF1, TYMP), a similar clinical phenotype was described in patients carrying mutations in the nuclear-encoded polymerase gamma[ncbi.nlm.nih.gov] Four laboratories have recently identified GFRAL, an orphan receptor of the glial-derived neurotrophic factor (GDNF) receptor α family, as the receptor for MIC-1/GDF15, signaling[ncbi.nlm.nih.gov] It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.[prnewswire.com] […] receptor-gamma coactivator 1 alpha ; PPAR-γ , peroxisome proliferator-activated receptor-gamma ; RyR1 , ryanodine receptor/Ca 2 release channel ; SARM , selective androgen[biochemj.org] Genetic inhibition of PARP activity attenuated the deleterious effects seen on depleted muscles in mouse models of oncologic cachexia.[ncbi.nlm.nih.gov]

  • Retinoid

    Vitamin D Receptor (VDR), Retinoid X Receptor (RXR) and Peroxisome Proliferator-activated Receptor γ (PPARγ) are known to interact with TRs by forming functional heterodimers[ncbi.nlm.nih.gov] The patient responded well to topical PUVA and systemic etretinate (retinoid-PUVA) and intravenous IFN-gamma.[ncbi.nlm.nih.gov] However, the active conformation of HX531 for RXRs is not well established.[ncbi.nlm.nih.gov] The promiscuous protein retinoid X receptor (RXR) displays essential allosteric regulation of several members in the nuclear hormone receptor superfamily via heterodimerization[ncbi.nlm.nih.gov] TRETINOIN All-trans-retinoic acid  1st retinoid introduced into clinical use – nearly 4 decades ago, for topical Rx of acne vulgaris MOA :  By reducing microcomedone formation[de.slideshare.net] Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent transcription factor that plays an important role in regulating glucose metabolism.[ncbi.nlm.nih.gov]

  • Phenelzine

    This effect was supported by the reduced expression in the key adipogenic transcription factors peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and CCAAT/enhancer[ncbi.nlm.nih.gov] There were significant reductions in platelet MAO activity, urinary MHPG excretion, and depressive symptoms in all of the patients.[ncbi.nlm.nih.gov] Drug Interactions In patients receiving nonselective monoamine oxidase (MOA) inhibitors in combination with serotoninergic agents (e.g., dexfenfluramine, fluoxetine, fluvoxamine[druglib.com] Fenelzina [Inn-Spanish] Interactions In patients receiving nonselective monoamine oxidase (MOA) inhibitors in combination with serotoninergic agents (e.g., dexfenfluramine[minclinic.ru] "Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with[en.wikipedia.org] The role of beta-adrenergic receptors in affective illness is reviewed in light of this case.[ncbi.nlm.nih.gov]

  • Smoking

    This study aims to investigate the role of peroxisome proliferator-activated receptor (PPAR) g in cigarette smoking-induced inflammation.[ncbi.nlm.nih.gov] We report a rare case of a patient with a vestibular schwanomma who underwent gamma knife irradiation and subsequently lost unilateral taste sensation.[ncbi.nlm.nih.gov] Recently we investigated the mechanism by which nicotine damages sperm through the evaluation of the expression of nicotinic receptors subunits in human spermatozoa. 8 nAChR[ncbi.nlm.nih.gov] Protein levels of Toll-like receptor 4 (TLR-4) and nuclear factor κB (NF-κB) were detected using Western blot and immunofluorescence.[ncbi.nlm.nih.gov] In the tumor cells of all five patients, epidermal growth factor receptor (EGFR) mutation gene sequencing identified a deletion in exon 19 of the EGFR gene, and all five patients[ncbi.nlm.nih.gov] Compared to small workplaces, very small workplaces offered cessation activities less often and had fewer tobacco policy restrictions.[ncbi.nlm.nih.gov]

    Missing: [MoA]
  • Chagas Disease

    Peroxisome proliferator-activated receptors (PPAR)-α, are known to modulate inflammation.[ncbi.nlm.nih.gov] A parametric survival analysis based on a generalized gamma distribution was used for assessing risk factors for treatment interruption.[ncbi.nlm.nih.gov] In the search for new treatments against Chagas disease and leishmaniasis, several studies have shown that hybrid molecules display high antiprotozoal activity and this emerging[ncbi.nlm.nih.gov] These receptors are possibly involved in the pathogenesis of chronic Chagas cardiomyopathy.[ncbi.nlm.nih.gov] […] outcome of Chagas disease (CD), has been associated with cytokine-enriched heart tissue inflammation, and high serum levels of transforming growth factor (TGFβ), interferon-gamma[ncbi.nlm.nih.gov] The trypanocidal activity of new nanostructured formulations of benznidazole to eliminate Trypanosoma cruzi was studied in vitro as well as their toxicity in two cultured[ncbi.nlm.nih.gov]

    Missing: [MoA]
  • Ammonium Chloride

    The mRNA level of peroxisome proliferator-activated receptor co-activator 1α (PGC-1α), citrate synthase, cytochome c and FOXO1 was elevated at rest following ACID (P 0.05)[ncbi.nlm.nih.gov] A method for purification and refolding of recombinant human interferon-gamma (hIFNgamma) from inclusion bodies is described.[ncbi.nlm.nih.gov] The present study was undertaken to assess the effects of acute metabolic acidosis on the activity of the renin-angiotensin-aldosterone system in 12 children with a mean age[ncbi.nlm.nih.gov] Due to the presence of these receptors, these leukemic T-cells can be selectively killed in vitro by monoclonal anti-interleukin 2 receptor antibody covalently linked to the[ncbi.nlm.nih.gov] METHYLPYRROLIDIN-2-ONE 2,5-Dichlorothiophene-3-sulfonamide 2-NAPHTHYL ISOCYANATE 4-NITROBENZAMIDINE, HYDROCHLORIDE 2-Formylfuran-5-boronic acid Iridium 1,3-DICHLORO-2-BUTENE interferon-gamma[chemicalbook.com] The effect of ammonium chloride treatment, used to eliminate contaminating red blood cells from lymphoid cell preparations, on the cytotoxic activity of human effector cells[ncbi.nlm.nih.gov]

    Missing: [MoA]
  • Troglitazone

    Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma have been shown to induce terminal differentiation of normal preadipocytes and human[ncbi.nlm.nih.gov] As a ligand for peroxisome proliferators-activated receptor gamma (PPAR gamma), troglitazone inhibits cell growth by mechanisms besides activating PPAR gamma.[ncbi.nlm.nih.gov] […] in T-lymphocyte activation.[ncbi.nlm.nih.gov] The role of the peroxisome proliferator-activated receptor-γ (PPARγ) in cell differentiation, cell cycle arrest and apoptosis has attracted increasing attention.[ncbi.nlm.nih.gov] In the present study, we showed that co-treatment with troglitazone (TGZ), a synthetic ligand of peroxisome proliferator-activated receptor γ (PPARγ), and TRAIL synergistically[ncbi.nlm.nih.gov] Peroxisome proliferator-activated receptor-gamma was expressed in human keratinocytes; ligands for PPARgamma inhibited the proliferation of normal and psoriatic human keratinocytes[ncbi.nlm.nih.gov]

    Missing: [MoA]