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106 Possible Causes for Allele, XRCC3, wt

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  • Osteosarcoma

    Exposure to radiation induces osteosarcoma cell apoptosis by upregulation of p53 both in U2OS (p53-wt) and exogenous p53-introduced MG-63 (p53-null) osteosarcoma cells.[ncbi.nlm.nih.gov] The average pooled odds ratio for the 9 risk alleles was 2.082 (range: 1.585 to 3.262).[ncbi.nlm.nih.gov] PTH in certain end-organ tissues, especially the kidney; the response in bone is unaffected because it normally expresses stimulatory G protein equally from both parental alleles[ncbi.nlm.nih.gov]

  • Troglitazone

    Wt 441.54 Formula C24H27NO5S Solubility DMSO Purity 98% Storage at -20 C 3 years Powder CAS No. 97322-87-7 Synonyms Rezulin SMILES code CC1 C(C( C2CCC(OC2 C1C)(C)COC3 CC C[adooq.com] This supports the hypothesis that risk alleles at SLC30A8 mark individuals with insulin-processing defects.[ncbi.nlm.nih.gov] LIG1, BRCA1, TOP2A, POLE2, RAD54L, GTSE1, POLE, PCNA, RAD51, MDC1, UIP1, RAD51AP1, HMGB2, RPA1, TYMS, POLQ, NEIL3, CCNA2, CHAF1A, PTTG1, MAP2K6, RFC5, FANCG, RPA3, FANCB, XRCC3[wjgnet.com]

  • Myelodysplasia

    The high frequency of these mutations in MDS, combined with their mutual exclusivity and noteworthy dependence on the WT allele, make targeting RNA splicing attractive in[ncbi.nlm.nih.gov] The XRCC3 protein also functions in the double-strand break repair pathway and directly interacts with and stabilizes RAD51.[haematologica.org] The nature of the remaining ferrochelatase allele was examined by polymorphism analysis and we discuss the insights that this patient's genotype may reveal about the pathogenesis[ncbi.nlm.nih.gov]

  • Gastrointestinal Stromal Tumor

    Mutations of the SDH gene are associated with many tumors, such as renal cell carcinoma, wild type gastrointestinal stromal tumors (WT GISTs) and hereditary paragangliomas[ncbi.nlm.nih.gov] Secondary resistance to IM in GISTs typically occurs due to several mechanisms that include hemi- or homo-zygous deletion of the wild-type KIT allele, overexpression of focal[ncbi.nlm.nih.gov] Allelic loss of 14q and 22q, NF2 mutation, and genetic instability occur independently of c-kit mutation in gastrointestinal stromal tumor.[emedicine.medscape.com]

  • Fanconi Anemia

    Wilms tumor (WT) is the most common primary renal tumor in childhood.[ncbi.nlm.nih.gov] Although several cases appeared to carry missense variants, no bi-allelic pathogenic mutations were identified, indicating that bi-allelic mutations in these FA-genes do not[ncbi.nlm.nih.gov] Role of RAD51C and XRCC3 in genetic recombination and DNA repair . J. Biol. Chem. 282 , 1973–1979 (2007). 14. Badie, S. et al.[nature.com]

  • Hereditary Breast Cancer

    Patients with VUS/WT BRCA1 were predominantly of luminal B subtype with histological grades I and II.[ncbi.nlm.nih.gov] Missense substitution p.R415Q (rs1800067), a previously postulated breast cancer susceptibility allele, was subsequently screened for in a total of 3,698 breast cancer cases[ncbi.nlm.nih.gov] Familiar breast-ovarian cancer Atlas_Id 10062 Genes implicated in ATM BARD1 BRIP1 BRCA1 BRCA2 CASP8 CDH1 CHEK2 ESR1 HMMR NQO2 PALB2 PHB PPM1D PTEN RAD51 RAD54L STK11 TP53 XRCC3[atlasgeneticsoncology.org]

  • Temozolomide

    The brain/plasma distribution of talazoparib in Bcrp -/- versus wild-type (WT) mice did not differ, whereas the brain/plasma ratio in Mdr1a/b -/- mice was higher than WT mice[ncbi.nlm.nih.gov] Patients carrying the G allele of MGMT (rs2308327) exhibited a 240% increase in risk of toxicity (95% CI, 0.99–5.84). Table 5.[academic.oup.com] Wt 194.15 Formula C 6 H 6 N 6 O 2 Storage Store at RT Purity 99% (HPLC) CAS Number 85622-93-1 PubChem ID 5394 InChI Key BPEGJWRSRHCHSN-UHFFFAOYSA-N Smiles CN1N NC2 C(N CN2C1[tocris.com]

  • Proximal Renal Tubular Acidosis

    Whereas the activities of R298S, A799V, and R881C were 15 to 40% of the wild-type (WT) activity, T485S and R510H, as a result of poor surface expression, showed almost no[ncbi.nlm.nih.gov] The absence of this mutation in 156 alleles of 78 normal individuals indicates that this mutation is related to the disease and is not a common DNA sequence polymorphism.[ncbi.nlm.nih.gov] PLAT, PROC, PROS1, PROZ, SERPINC1, SERPIND1, SERPINE1, SERPINF2, THBD, VKORC1, VWF)Pan113Tumori della pelle (CDKN2A, EPCAM, MC1R, MITF, MLH1, MSH2, MSH6, PMS1, PMS2, PTCH1, XRCC3[bredagenetics.com]

  • Cerebro-Oculo-Facio-Skeletal Syndrome 1

    […] clinical findings in 102 individuals and recommendations for care Wilson BT, Stark Z, Sutton RE, Danda S, Ekbote AV, Elsayed SM, Gibson L, Goodship JA, Jackson AP, Keng WT[disorders.eyes.arizona.edu] In Rr individuals the R allele masks the presence of the r allele, thus, allele R is dominant to allele r, and allele r is recessive to allele R.[wikivisually.com] Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire. [ PMID 17705814 ] Polymorphisms in XPC, XPD, XRCC1, and XRCC3[snpedia.com]

  • Squamous Cell Carcinoma of the Head and Neck

    Kim DH, Kim WT, Lee JH, et al., Analysis of the prognostic factors for distant metastasis after induction chemotherapy followed by concurrent chemoradiotherapy for head and[touchoncology.com] […] and BRIP1 mRNA expression, compared to the A allele with the presence of miR-101.[ncbi.nlm.nih.gov] ., Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis, Cancer Epidemiol Biomarkers Prev., 2005, 14, 1747–1753[degruyter.com]