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3,115 Possible Causes for Alternative, RNA, Splicings

  • Osteoporosis

    Preserving periodontally compromised abutments in patients who are actively undergoing oral and intravenous bisphosphonate treatment for osteoporosis provides an alternative[ncbi.nlm.nih.gov] The present study aimed to identify the key long non‑coding RNAs (lncRNAs) in PMOP through RNA sequencing.[ncbi.nlm.nih.gov] Sanger sequencing showed 41bp deletion in splice region following exon 1 of WNT1 gene in homozygous state.[ncbi.nlm.nih.gov]

  • Venezuelan Equine Encephalitis

    The new assay provides a reliable high-throughput method for the detection and quantitation of VEEV RNA in clinical and field samples and allows a rapid differentiation from[ncbi.nlm.nih.gov] This first evidence of the host gene alternatively spliced mRNA induction by RNA viruses raises the questions of its biological role, regulation mechanisms of alternative[ncbi.nlm.nih.gov] We used a HA tagged nsP3 infectious clone (rTC-83-nsP3-HA) to identify and validate two RNA helicases: DDX1 and DDX3 that interacted with VEEV-nsP3.[ncbi.nlm.nih.gov]

  • Coxsackievirus Infection

    These alternatively spliced CAR proteins are released from transfected HeLa cells confirming that they are soluble proteins.[ncbi.nlm.nih.gov] Peroxynitrite inhibits viral replication in vitro, in part by inhibiting viral RNA entry into the host cell.[ncbi.nlm.nih.gov] The adenosine-uridine (AU)-rich element RNA binding factor 1 (AUF1) is an integral component in the regulation of gene expression.[ncbi.nlm.nih.gov]

  • Herpes Simplex Virus 1 Infection

    These forms were observed following infection with a series of recombinant viruses that produce truncated ICP27 polypeptides, suggesting that alternative splicing is not involved[ncbi.nlm.nih.gov] Deep RNA sequencing was used to profile the global changes in circRNAs, genes, and miRNAs following HSV-1 infection.[ncbi.nlm.nih.gov] STING has emerged in recent years as a key player in orchestrating innate immune responses to cytosolic DNA and RNA derived from pathogens.[ncbi.nlm.nih.gov]

  • African Trypanosomiasis

    Trypanosome alternative oxidase is a parasite specific enzyme whose inhibition by the natural product ascofuranone (AF) has been shown to be curative in murine models.[ncbi.nlm.nih.gov] Data from our proof-of-concept study show that SL RNA detection has high potential as a test of cure.[ncbi.nlm.nih.gov] We propose an alternative 'reverse' approach to address this problem, conceptualised as using appropriate statistical methods to test the performance of combinations of established[ncbi.nlm.nih.gov]

  • Limb-Girdle Muscular Dystrophy

    The present study presents a novel association between a muscular disorder and a RNA-related gene and reinforces the importance of RNA binding/processing proteins in muscle[ncbi.nlm.nih.gov] Nanospan is an alternatively spliced isoform of sarcospan.[ncbi.nlm.nih.gov] The RNA-binding proteins hnRNPA1 and hnRNPA2/B1 accumulated and co-localized with DNAJB6 at sarcoplasmic stress granules suggesting that these proteins maybe novel DNAJB6b[ncbi.nlm.nih.gov]

  • Keloid

    Knockdown of β-catenin was achieved by delivering small interfering RNA to target β-catenin.[ncbi.nlm.nih.gov] Dysregulated alternative splicing events have been demonstrated in tumours and fibrosis.[ncbi.nlm.nih.gov] Topical steroid and silicone dressings are a patient friendly and non-invasive treatment alternative.[ncbi.nlm.nih.gov]

  • Childhood Absence Epilepsy

    EEG might be an alternative approach to explore the effects of AEDs on the central nervous system.[ncbi.nlm.nih.gov] […] encompassing the gene CHRNB2 coding for the β-2 subunit of the nicotinic acetylcholine receptor and the gene ADAR coding for adenosine deaminase, an enzyme responsible for RNA[ncbi.nlm.nih.gov] The GABRG2 intron 6 splice donor site was found to be mutated from GT to GG.[ncbi.nlm.nih.gov]

  • Parasite

    RNA contains over 100 modified nucleotides that are created post-transcriptionally, among which pseudouridine (Ψ) is one of the most abundant.[ncbi.nlm.nih.gov] […] splicing or alternative start/ stop sites.[ncbi.nlm.nih.gov] T. cruzi RBP42 structurally resembles T. brucei RBP42, sharing an NTF2 domain at its amino terminus and a single RNA-binding domain (specifically, the RNA recognition motif[ncbi.nlm.nih.gov]

  • CHARGE Syndrome

    We show that Fam172a plays a key role in the regulation of cotranscriptional alternative splicing, notably by interacting with Ago2 (Argonaute-2) and Chd7.[ncbi.nlm.nih.gov] In this region DHX29 serves as the candidate gene as it encodes an ATP-dependent RNA-helicase that is involved in the initiation of RNA translation.[ncbi.nlm.nih.gov] Strikingly, MO-mediated knockdown of the jumonji domain-containing histone demethylase fbxl10/kdm2bb, a repressor of ribosomal RNA (rRNA) genes, rescues cell proliferation[ncbi.nlm.nih.gov]