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481 Possible Causes for Antagonists,, Cysteine, Proteinase

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  • Momordica Charantia

    The activity of the enzyme was inhibited by sulfide, azide and L-cysteine.[eurekaselect.com] The activity in BMSE-W was unaffected by heat and proteinases treatments, and eluted in the total volume of size-exclusion HPLC, suggesting the small, organic nature of the[ncbi.nlm.nih.gov] In conclusion, this study demonstrates, for the first time as far as we know, the partial agonist/antagonist activity via ER of four new and one known cucurbitane-type triterpenoids[ncbi.nlm.nih.gov]

  • Acanthamoeba

    T5, T15, T11 and T10 genotypes have a high potential for pathogenicity and a very high degree of virulence due to their production of serine proteases and extracellular cysteine[ncbi.nlm.nih.gov] The use of proteinase inhibitors on a tissue culture model proved that the proteinase activity is critical for developing focal lesions in HeLa cell monolayers.[ncbi.nlm.nih.gov] Growth assays showed proliferation and lethal effects of exposure to mAChR1 agonist and antagonist respectively.[ncbi.nlm.nih.gov]

  • Fasciola Hepatica

    Cystatins are small, phylogenetically conserved proteins that are tight-binding inhibitors of cysteine proteinases.[ncbi.nlm.nih.gov] FhCaM3 binds to the calmodulin antagonists trifluoperazine and W7, but not to the myosin regulatory light chain binding compound praziquantel.[ncbi.nlm.nih.gov] It secretes a large family of cysteine peptidases, termed cathepsins, that are important virulence factors.[ncbi.nlm.nih.gov]

  • Necator Americanus

    This bioinformatics based study focuses on eight of the cathepsin B like cysteine proteases (CPs) of the worm, which could have immense pathogenic potential.[biorxiv.org] All the skin macromolecules tested were hydrolyzed by aspartyl proteinase activity, which was inhibitable by pepstatin A.[ncbi.nlm.nih.gov] Na-ASP-2 is a useful homology model for NIF, a natural antagonistic ligand of CR3 receptor. From these modeling studies, possible binding modes were predicted.[ncbi.nlm.nih.gov]

  • Streptococcus Agalactiae

    PTSFru2 is involved in the activation of the fru2 promoter, and the histidine-67 of EIIAFru2 and the cysteine-9 of EIIBFru2 are important for this function.[ncbi.nlm.nih.gov] The activities of fosfomycin, rifampicin, benzylpenicillin, daptomycin, gentamicin, levofloxacin, proteinase K and their combinations on planktonic and/or biofilm-embedded[ncbi.nlm.nih.gov] Through coincubation with supplemental arginine and the arginine antagonist canavanine, we show that arginine availability is a determinant of GBS cytotoxicity and that the[ncbi.nlm.nih.gov]

  • Trichuris Trichiura

    The encoded proteins are composed of tandem arrays of alternating 50- and 51-amino-acid domains within which the positioning of the cysteine residues is highly conserved.[ncbi.nlm.nih.gov] Praziquantel was not shown to have synergistic or antagonistic effects with albendazole.[ncbi.nlm.nih.gov] Brown A, Girod N, Billett EE, Pritchard DI: Necator americanus (human hookworm) aspartyl proteinases and digestion of skin macromolecules during skin penetration .[link.springer.com]

  • Creutzfeldt Jakob Disease

    […] presence of massive regulation of Ca2 responsive genes in sCJD brain tissue, accompanied by two Ca2 -dependent processes: endoplasmic reticulum stress and the activation of the cysteine[ncbi.nlm.nih.gov] An examination of her cerebrospinal fluid revealed increased levels of 14-3-3 and total tau proteins, and abnormal conformation of the proteinase K-resistant prion protein[ncbi.nlm.nih.gov] Here we show that blocking IL-1β receptors with anakinra, the human recombinant form of the endogenous IL-1 receptor antagonist used to treat rheumatoid arthritis, normalizes[ncbi.nlm.nih.gov]

  • Mineralocorticoid

    In the present work, we describe an already known mutation in a new patient affected by apparent mineralocorticoid excess, which results in an arginine-to-cysteine mutation[ncbi.nlm.nih.gov] […] middle cerebral artery; MDM2, murine double minute type 2; MMP, matrix metalloproteinase; MR, mineralocorticoid receptor; PA, primary aldosteronism; PCPE-1, procollagen C-proteinase[clinsci.org] The role of nonsteroidal mineralocorticoid receptor antagonists (MRAs) in DKD is being evaluated in ongoing clinical trials.[ncbi.nlm.nih.gov]

  • Streptococcal Infection

    Cysteine protease (Exotoxin B) Pyoderma strains of S. pyogenes can colonize or survive on normal skin surfaces for extended periods.[atsu.edu] […] digests host connective tissue, hyaluronic acid, and the organism's own capsule), streptokinases (proteolytic), and streptodornase A-D (deoxyribonuclease activity). [ 13 ] Proteinase[emedicine.medscape.com] In the former, a surface EMG showed short-duration (30 to 60 ms), highly frequent (6 to 8 Hz) and synchronous discharges of multiple muscles, including the antagonists, suggesting[ncbi.nlm.nih.gov]

  • Oral Candidiasis

    The CZ-loaded polyvinylpyrrolidone (PVP)/hydroxypropyl-β-cyclodextrin (HPβCD) fiber was coated with chitosan-cysteine (CS-SH)/polyvinyl alcohol (PVA) to increase the mucoadhesive[ncbi.nlm.nih.gov] The capability of the Candida samples in producing phospholipases and proteinases was also determined.[ncbi.nlm.nih.gov] Therefore, probiotics, which counter pathogenic microorganisms through competitive, antagonistic, and immunological effects, have been used by some clinicians.[ncbi.nlm.nih.gov]