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  • Interleukin-2

    Description The International Space Station provides a modern platform to study physiology and molecular changes in space.[nasa.gov] The authors report the case of a patient with a metastatic renal cell carcinoma who had an asymptomatic intra-epidural metastasis in the thoracic spine, which became symptomatic[ncbi.nlm.nih.gov] Interleukin-2-receptor signaling.[ncbi.nlm.nih.gov] It is difficult to differentiate angiosarcoma from epithelioid hemangioendothelioma based on the image findings and pathological findings of percutaneous liver biopsy.[ncbi.nlm.nih.gov] The survivor whose condition 23 months following introduction of IL-2 therapy is very good, demonstrates that IL-2 offers some chance to these hopeless patients.[ncbi.nlm.nih.gov] System Agents Anti-HIV Agents Anti-Retroviral Agents Antineoplastic Agents, Phytogenic Tubulin Modulators[clinicaltrials.gov] Ten patients who had received low-dose IL-2 were retrospectively identified.[ncbi.nlm.nih.gov] Due to the toxicities associated with systemic IL-2, an aerosolized delivery approach has been developed, which enables localized delivery and a higher local immune cell activation[ncbi.nlm.nih.gov] Introduction IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes.[prospecbio.com] Using a human OS mouse model, we demonstrated the efficacy of this approach.[ncbi.nlm.nih.gov]

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  • Thyroid Cancer

    […] locoregional, histopathologically proven, fluorodeoxyglucose positron emission tomography/computed tomography-avid recurrence of follicular thyroid carcinoma in the left subglottic space[ncbi.nlm.nih.gov] Our case shows that epidural metastases from endocrine origin might represent a clinical pitfall in Ga-DOTATATE PET.[ncbi.nlm.nih.gov] Abstract INTRODUCTION: To assess the rate of thyroid cancer and mortality rate in a cohort of patients who received RAI¹³¹ treatment for hyperthyroidism and to report the[ncbi.nlm.nih.gov] […] administration & dosage Antineoplastic Agents/administration & dosage Antineoplastic Agents, Phytogenic/administration & dosage Antineoplastic Combined Chemotherapy Protocols[ncbi.nlm.nih.gov] […] radioiodine remnant ablation (RRA) and to compare them to patients receiving low dose of iodine (30 mCi).[ncbi.nlm.nih.gov] Siteman’s thyroid cancer program can provide broad-based treatments because of its strong multidisciplinary approach.[siteman.wustl.edu] We report 4 cases of PTC metastasis to unusual sites: (1) the occipital skull and internal jugular vein, (2) the parapharyngeal space, (3) the sternocleidomastoid muscle,[ncbi.nlm.nih.gov] INTRODUCTION: Thyroid cancer is the most common endocrine malignancy; the most common type of thyroid cancer is papillary thyroid cancer which accounts for approximately 90%[ncbi.nlm.nih.gov] Abstract Introduction The annual incidence of thyroid cancer is known to vary with geographic area, age and gender.[ncbi.nlm.nih.gov] Single photon emission computed tomography/low-dose computed tomography (SPECT/CT) was added for children whose planar findings were inconclusive.[ncbi.nlm.nih.gov]

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  • Chemotherapy

    Intrapleural Chemotherapy Treatments Chemotherapy can be given into the pleural cavity (the space between the lung and the lining of the lung).[chemocare.com] OBJECTIVE: To assess the effectiveness of prolonged perioperative thoracic epidural analgesia (PEA) on long term survival of patients who underwent a complete cytoreductive[ncbi.nlm.nih.gov] Biological Therapy Interferon and interleukin-2 are commonly used biological agents.[healthcommunities.com] After ultrasound-guided percutaneous embolization, bleeding did not recur. Unfortunately, the patient died of liver dysfunction caused by severe SOS.[ncbi.nlm.nih.gov] INTRODUCTION: Paraganglioma (PGL) is a rare neuroendocrine tumor.[ncbi.nlm.nih.gov] A variety of antineoplastic agents displayed activity when administered with metronomic schedules in preclinical models of gastrointestinal cancers.[ncbi.nlm.nih.gov] Doses greater than or equal to 500mg/m2 are considered high, while doses 50 to 500 mg/m2 are intermediate. Low dose is considered under 50 mg/m2.[verywellhealth.com] This approach to treatment focuses on stimulating the patient’s immune system to fight disease.[siteman.wustl.edu] Medication Name Also Know As… 5-fluorouracil 5-FU, Efudix 6-mercaptopurine 6-MP, Puri-Nethol, Mercaptopurine Aldesleukin Proleukin, IL-2, Interleukin-2, r-serHuIL Alendronate[curesearch.org] When the tumor progressed again, he underwent a percutaneous liver biopsy, which led to the diagnosis of MAEC.[ncbi.nlm.nih.gov]

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  • Clear Cell Sarcoma

    KEYWORDS: Clear cell; parapharyngeal space; rare; sarcoma[ncbi.nlm.nih.gov] Unusual soft tissue sites (scalp, epidural, nasopharynx, neck, paraspinal, ovary, abdominal wall, axilla) and other sites (orbit) have been reported.[emedicine.medscape.com] Examples of biologic therapy for metastatic kidney cancer include interferon alpha or interleukin-2.[webmd.com] Obiorah I.E....A9zdemirli M. 2017 26 Clear cell sarcoma-like tumor of the gastrointestinal tract: A clinicopathological review. ( 28887884 ) Washimi K....Yokose T. 2017 27 Percutaneous[malacards.org] INTRODUCTION: Clear cell sarcoma (CCS) is an aggressive tumor, typically developing in tendons or aponeuroses.[ncbi.nlm.nih.gov] Gov't MeSH terms Adult Antigens, Neoplasm/immunology Antigens, Neoplasm/metabolism Antineoplastic Agents/therapeutic use Female Humans Immunophenotyping Indoles/therapeutic[ncbi.nlm.nih.gov] Very-low-dose therapeutic radiation therapy (RT) may be used to treat infants with Stage 4S neuroblastoma.[ncbi.nlm.nih.gov] […] tumor in growth in CCSK is firm, non friable and non-adherent, and tumor en bloc resection may be possible through a limited venotomy via primary abdominal approach.[ncbi.nlm.nih.gov] INTRODUCTION: Clear cell sarcoma of the gastrointestinal tract (CCS-GI) is an extremely rare and aggressive tumor, which often mimics other neoplastic processes.[ncbi.nlm.nih.gov] Abstract INTRODUCTION: Clear cell sarcoma of the kidney (CCSK) is childhood neoplasm with its own distinctive pattern of metastasis and may appear after a disease free interval[ncbi.nlm.nih.gov]

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  • Ethanol

    A computed tomography scan showed that the inferior, medial, and superior extraocular muscles were bilaterally enlarged, the perineural space at the orbital cone was slightly[ncbi.nlm.nih.gov] High glucose decreased glutathione content; stimulated the production of reactive oxygen species, interleukin-6, tumor necrosis factor-alpha, and prostaglandin E 2 ; raised[ncbi.nlm.nih.gov] CT-guided percutaneous ethanol injection (PEI) was performed for this high surgical risk patient.[ncbi.nlm.nih.gov] INTRODUCTION: Ethanol exposure to developing brain may alter the growth and differentiation of neurological cells resulting in unfavorable pathologies.[ncbi.nlm.nih.gov] KEYWORDS: Hepatocellular carcinoma; Intrinsic apoptosis; SREBP1; Zhiheshouwu ethanol extract MeSH terms, Substances MeSH terms Antineoplastic Agents, Phytogenic/pharmacology[ncbi.nlm.nih.gov] OBJECTIVE: This study investigated whether preceding ethanol intake impairs glucose response to low-dose glucagon in individuals with type 1 diabetes.[ncbi.nlm.nih.gov] Ethanol was injected into the liver parenchyma surrounding the isolated bile duct via the percutaneous transhepatic approach under sonographic guidance on POD 78 in order[ncbi.nlm.nih.gov] An acrylic bar was positioned between two dentin specimens and impression material was added to create a block, simulating an instrumented root canal space.[ncbi.nlm.nih.gov] INTRODUCTION: EUS-guided ethanol ablation of insulinoma is a new method of treatment of this neuroendocrine tumour.[ncbi.nlm.nih.gov] Keeping these tanks full will reduce water buildup in the fuel by eliminating both available air space and tank wall surface space for condensation to accumulate.[government-fleet.com]

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  • Mesothelioma

    For mesothelioma, chemotherapy may be given directly into the pleural space (intrapleurally).[ww2.mc.vanderbilt.edu] Usually, opioids, both transdermal and delivered via indwelling epidural catheters, are used.[merckmanuals.com] The cytokine protein Interleukin-2 (IL2) is capable of stimulating the growth of immune system cells called "T-cells."[asbestosnetwork.com] Click to download a PDF leaflet on percutaneous cordotomy A procedure called a Percutaneous Spinal Cordotomy may help relieve pain that has not responded to conventional pain[mesothelioma.uk.com] Mesothelioma: Introduction ON THIS PAGE : You will find some basic information about this disease and the parts of the body it may affect.[cancer.net] Agents Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Folic Acid Antagonists Nucleic Acid Synthesis Inhibitors[clinicaltrials.gov] dose rapamycin therapy, an mTOR inhibitor.[ncbi.nlm.nih.gov] The first includes expenditure borne by the State and other public bodies (medical care costs, insurance, tax and benefits), while the latter uses the human capital approach[ncbi.nlm.nih.gov] Use the menu below to choose the Introduction section to get started. Or, you can choose another section to learn more about a specific question you have.[cancer.net] Introduction Malignant mesothelioma is a relatively uncommon malignancy.[bloodjournal.org]

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  • Cauda Equina Syndrome

    Caudal migration of the bullet within the spinal subarachnoid space leads to the appearance of cauda equina syndrome.[ncbi.nlm.nih.gov] His pain had greatly intensified 1 day after spinal epidural steroid injection.[ncbi.nlm.nih.gov] KEYWORDS: Cauda equina syndrome; Endoscope; Lumbar disc herniation; Percutaneous discectomy[ncbi.nlm.nih.gov] INTRODUCTION: Cauda equina syndrome (CES) is a condition with significant implications and medico-legal profile.[ncbi.nlm.nih.gov] Publication type, MeSH terms, Substance Publication type Case Reports MeSH terms Aged Antineoplastic Combined Chemotherapy Protocols/therapeutic use Biomarkers, Tumor/analysis[ncbi.nlm.nih.gov] Adjuvant medication such as low dose an antidepressants (e.g. amitriptyline); . anticonvulsants ,.(e.g.[caudaequina.org] Surgical outcome immediately and 3, 6, 12, 36 months after the surgery were compared to evaluate the effectiveness two different approaches.[ncbi.nlm.nih.gov] INTRODUCTION: Patients with cauda equina syndrome (CES) are frequently referred late when neurological damage cannot be reversed.[ncbi.nlm.nih.gov] Adjuvant medication such as low dose antidepressants, anticonvulsants, and neurontin often help the person.[disabled-world.com] BACKGROUND CONTEXT: Percutaneous intradiscal therapies are gaining popularity as a regenerative treatment option for spinal disc degeneration.[ncbi.nlm.nih.gov]

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  • Famotidine

    Take any remaining doses for that day at evenly spaced intervals, but do not take a double dose.[clevelandclinic.org] Abstract Lymphokine-activated killer cell (LAK) cytotoxicity against tumor cells is induced by the use of high-dose infusional interleukin-2 (IL-2).[ncbi.nlm.nih.gov] METHODS: Patients with acute coronary syndrome or elective percutaneous coronary interventions treated with aspirin and clopidogrel cotherapy were randomized to receive esomeprazole[ncbi.nlm.nih.gov] INTRODUCTION: Pharmacokinetic outcomes of transporter-mediated drug-drug interactions (TMDDIs) are increasingly being evaluated clinically.[ncbi.nlm.nih.gov] […] antacids within seven days before enrollment or if they were taking 7.5 mg or more of prednisolone daily (or an equivalent dose of another corticosteroid), methotrexate, or antineoplastic[nejm.org] BACKGROUND AND AIM: Proton-pump inhibitors are known to be effective in the treatment and prevention of ulcers related to low-dose aspirin (LDA), but few reports address H2[ncbi.nlm.nih.gov] In conclusion, the study confirmed that ternary complexation can be utilized as an alternative approach for effective taste masking.[ncbi.nlm.nih.gov] Abstract High-dose interleukin-2 (IL-2), given via continuous intravenous (i.v.) infusion, induces lymphokine-activated killer (LAK) cell cytotoxicity against tumor cells.[ncbi.nlm.nih.gov] Home Introduction Clinical Course Phenotypes Immune Features Clinical Outcomes Causality Severity Grading Likelihood Scale Classes of Drugs Submit a Case Report Meetings/Alerts[livertox.nih.gov] BACKGROUND: There are few therapeutic options for the prevention of gastrointestinal mucosal damage caused by low-dose aspirin.[ncbi.nlm.nih.gov]

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  • Bleeding Diathesis

    Nineteen patients with intracranial hemorrhage had bleeding in the subdural space (79%), intracerebral (42%), intraventricular (32%), and subarachnoid space (5.2%).[ncbi.nlm.nih.gov] ) after epidural analgesia for pain relief is described.[ncbi.nlm.nih.gov] The choice of shockwave lithotripsy, percutaneous nephrolithotomy or ureteroscopy with laser lithotripsy for treatment of lithiasis should be determined with regard to these[ncbi.nlm.nih.gov] INTRODUCTION AND OBJECTIVES: The management of urolithiasis in patients on anticoagulants presents a challenge to the endourologist.[ncbi.nlm.nih.gov] It has potent estrogenic activity and substantial antineoplastic effects in patients with prostate cancer. 1 , 2 We describe a patient with profound bleeding diathesis after[nejm.org] Erythromelalgia is frequently preceded or followed by atypical transient neurologic, ocular or coronary ischemic symptoms, which specifically respond to low-dose aspirin or[ncbi.nlm.nih.gov] Many surgeons who routinely use this approach do not require their patients to discontinue anticoagulation therapy before surgery.[aao.org] Radiographic findings at this stage may include joint space narrowing, osseous erosions, subchondral cysts, sclerosis, and osteophytosis.[appliedradiology.com] INTRODUCTION: Noonan syndrome (NS) is characterized by dysmorphic facies, short stature and congenital heart defects.[ncbi.nlm.nih.gov] INTRODUCTION: Factor VIII (FVIII) treatment for hemophilia A has difficulties in correcting bleeding diathesis in the presence of inhibitors.[ncbi.nlm.nih.gov]

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  • Myelofibrosis

    A 56-year-old woman with myelofibrosis and newly diagnosed space-occupying lesion of the chest wall underwent whole-body PET/CT for further evaluation.[ncbi.nlm.nih.gov] MRI confirmed CT findings for the spine noting also an enhanced epidural collection. Biopsies did not reveal malignant cells.[ncbi.nlm.nih.gov] METHODS: Serum levels of interleukin-8 (IL-8) and lymphoid-associated activation markers - soluble interleukin-2 receptor (sIL-2R) and immunoglobulin-free light chains (FLC[ncbi.nlm.nih.gov] INTRODUCTION/BACKGROUND: Myelofibrosis (MF) is a chronic myeloproliferative neoplasm that presents with a heterogeneous clinical phenotype and prognosis.[ncbi.nlm.nih.gov] KEYWORDS: chronic lymphocytic leukemia; chronic myeloid leukemia; erythron system; multiple myeloma; myelofibrosis MeSH terms, Substance MeSH terms Adult Antineoplastic Combined[ncbi.nlm.nih.gov] Low-dose thalidomide in myelofibrosis , John T. Reilly , Mary Frances McMullin , Natasha J. Curtin , Deepti Radia , Claire N.[haematologica.org] The development or worsening of cytopenias in patients receiving ruxolitinib uncovered an unmet need that has been addressed by alternative approaches.[ncbi.nlm.nih.gov] Marrow becomes progressively hypocellular and diffusely fibrotic, and late in the disease the marrow space can become converted to bone (osteosclerosis).[sharinginhealth.ca] The patient was treated with a multitargeted approach specifically developed for cachexia including oral l-carnitine, celecoxib, curcumin, lactoferrin, and subcutaneous recombinant[ncbi.nlm.nih.gov] As a result there is less space for healthy bone marrow so the bone marrow goes on to produce poor quality blood.[bonemarrowmx.com]

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