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  • Stem Cell Transplant

    University School of Health Sciences, Toyoake, Japan. 3 Division of Molecular Genetics, Fujita Health University, Toyoake, Japan. 4 Department of Hematology, The Japanese Red[ncbi.nlm.nih.gov] What is peripheral blood stem cell transplantation?[medicinenet.com] KEYWORDS: Bloodless; HSCT; Hematology-oncology; Hematopoietic stem cell transplantation; Transfusion; Transfusion-free[ncbi.nlm.nih.gov] Abstract We propose a novel approach for the treatment of atrophic bone non-unions via parallel applications of extracorporeal shock wave therapy (ESWT) and an autologous[ncbi.nlm.nih.gov] Autologous Transplant: A Guide for Patients and Caregivers Read our guide to autologous stem cell transplants.[mskcc.org] […] cares for children with all types of blood disorders, including: Sickle cell anemia Hemophilia (when the blood doesn’t clot) Bleeding Thrombotic disorders (problems with veins[pennstatehershey.org] blood cells, which carry oxygen ; and platelets, which help the blood to clot.[cancer.gov] Mantle cell lymphoma is a relatively rare malignancy, comprising fewer than 10% of all non-Hodgkin lymphomas.[ncbi.nlm.nih.gov] Now that the Stanford Laboratory for Cell and Gene Medicine is open, the program is capable of producing cells required for both cellular and gene therapies.[stanfordchildrens.org] These cells are then collected from the donor’s vein in a process called apheresis. Once collected, blood stem cells are delivered to the patient through a vein.[upmccancercenter.com]

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  • Paroxysmal Nocturnal Hemoglobinuria

    As a result, red blood cells break down too early. The red cells leak hemoglobin into the blood, which can pass into the urine.[nlm.nih.gov] Flow cytometry of the patient's peripheral blood demonstrated that 21.7% and 21.5% of the erythrocytes were CD59 and CD55 deficient, respectively, and 63.5% of the granulocytes[ncbi.nlm.nih.gov] The transfused red cells survive far longer than PNH cells.[nejm.org] While this therapeutic approach is effective, there is residual complement activity resulting from specific clinical scenarios as well as from upstream complement components[ncbi.nlm.nih.gov] We report a previously undescribed case of PNH occurring after autologous stem cell transplantation (ASCT) in a patient affected by relapsing non-Hodgkin's lymphoma.[ncbi.nlm.nih.gov] Retinal vein occlusion (RVO) is a frequent cause of vision loss but its relationship with PNH has not been studied systematically.[ncbi.nlm.nih.gov] It stops the breakdown of the red blood cells and may replace the need for blood transfusions.[healthline.com] , T-Cell, alpha-beta[ncbi.nlm.nih.gov] MATERIALS AND METHOD: We conducted a pilot, prospective, open-label, longitudinal clinical study with six PNH patients treated with eculizumab.[ncbi.nlm.nih.gov] […] understanding of the unique pathobiology of PNH in relationship both to complement physiology and immune-mediated bone marrow failure provides the basis for a systematic approach[ncbi.nlm.nih.gov]

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  • Hemolytic Transfusion Reaction

    A few residual transfused e-positive red cells were detected after the red cell exchange until POD 13.[ncbi.nlm.nih.gov] A patient with blood type A2 received peripheral blood stem cells from a blood type O donor. The patient was in critical condition due to treatment-related toxicity.[ncbi.nlm.nih.gov] The hemolytic transfusion reaction is a potentially severe adverse reaction to blood transfusion that may be divided into acute episodes, occurring during the first 24 hours[symptoma.com] […] recurrence was successfully prevented by rituximab administration prior transfusion, supporting the safe use of rituximab to prevent DHTR in SCD patients as a second line approach[ncbi.nlm.nih.gov] This case of a hemolytic reaction adds to the known risks of autologous transfusion.[ncbi.nlm.nih.gov] Mild symptoms may be treated with: Acetaminophen, a pain reliever to reduce fever and discomfort Fluids given through a vein (intravenous) and other medicines to treat or[medlineplus.gov] We report the use of automated red blood cell exchange (ARE) to limit hemolysis associated with an emerging DHTR.[ncbi.nlm.nih.gov] Abstract A patient suffering from delayed hemolytic transfusion reaction with anti-Jkb erythrocyte antibody after open heart surgery is reported on.[ncbi.nlm.nih.gov] No evidence of intravascular hemolysis was observed upon visual comparison of the pre- and post-transfusion peripheral blood plasma.[ncbi.nlm.nih.gov] Current diagnostic approaches are complex and not consensual; they are based on assessment of hemoglobin (Hb) drop and enhanced hemolysis, features also seen during classical[ncbi.nlm.nih.gov]

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  • Hereditary Spherocytosis

    Both these diseases can be readily diagnosed by various laboratory approaches that include red blood cell cytology, flow cytometry, ektacytometry, electrophoresis of the red[ncbi.nlm.nih.gov] Peripheral blood smears were performed to examine the red blood cell morphology.[ncbi.nlm.nih.gov] […] avoid transfusion.[ncbi.nlm.nih.gov] The authors have developed a novel LPS technique that combines the benefits of partial splenectomy with those of a laparoscopic approach.[ncbi.nlm.nih.gov] .: Amyloid-associated amyloidosis in a HCV carrier with non-Hodgkin's lymphoma who had been treated with autologous stem cell transplantation and rituximab.[kawasaki-m.ac.jp] The complications of splenectomy include an increased risk of thrombosis, usually presenting with deep vein thrombosis or pulmonary embolism.[ncbi.nlm.nih.gov] Accordingly, red blood cells from HS subjects were less sensitive to cryohemolysis than normal erythrocytes after inhibition of the AQP1 water channel.[ncbi.nlm.nih.gov] OBJECTIVES: To determine whether the values of mean cell volume (MCV) and mean sphered cell volume (MSCV) can distinguish hereditary spherocytosis (HS) from thalassemia.[ncbi.nlm.nih.gov] There are few reports on adult open-heart surgery for patients with hereditary spherocytosis.[ncbi.nlm.nih.gov] On further evaluation, he was found to have patent foramen ovale (PFO) and deep vein thrombosis (DVT), leading to paradoxical embolism.[ncbi.nlm.nih.gov]

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  • Aplastic Anemia

    Abstract Aplastic anemia (AA) and pure red cell aplasia (PRCA) appear to be more prevalent in Asian countries including Korea.[ncbi.nlm.nih.gov] PURPOSE: To report a case of severe, bilateral, rapidly progressing peripheral retinal nonperfusion associated with underlying aplastic anemia.[ncbi.nlm.nih.gov] This is the second documented case of anti-AnWj to cause a hemolytic transfusion reaction.[ncbi.nlm.nih.gov] Diagnosis of AA requires a comprehensive approach with prompt evaluation for inherited and secondary causes of bone marrow aplasia, while providing aggressive supportive care[ncbi.nlm.nih.gov] KEYWORDS: Autologous transplantation; Cord blood; Hepatitis-associated aplastic anemia[ncbi.nlm.nih.gov] Given through a tube inserted into a chest vein, the stem cells travel to the bone marrow and begin making new, healthy blood cells.[stjude.org] This means you do not have enough red blood cells, white blood cells or platelets. White blood cells fight germs, and platelets help blood clot.[ohsu.edu] Bone marrow remains the graft source of choice; peripheral blood stem cells may be acceptable in special circumstances in resource-constrained countries.[ncbi.nlm.nih.gov] Physiotherapy was performed to improve the mouth opening, and the patient was examined for HBsAg, HBsAb, and HIV; white blood cell and platelet count and coagulation tests[ncbi.nlm.nih.gov] Symptoms are due to the underproduction of red cells, white cells, and platelets.[nlm.nih.gov]

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  • Sickle Cell Disease

    Transfusion corrects anaemia and dilutes out the number of red cells able to cause vaso-occlusion and vascular damage.[ncbi.nlm.nih.gov] In stage II, peripheral arteriolar-venular anastomosis occurs as the eye adjusts to peripheral arteriolar occlusion, and blood is diverted from the occluded arterioles into[emedicine.com] […] who did not receive a transfusion.[ncbi.nlm.nih.gov] The two cases presented here demonstrate that a team-based, multidisciplinary approach can facilitate a successful transition.[ncbi.nlm.nih.gov] Gene therapy has curative potential, whereby autologous hematopoietic stem cells are genetically modified and transplanted, which would not be limited by matched donors, resulting[ncbi.nlm.nih.gov] Patients with sickle cell disease have a baseline hypercoaguable state and are at a greater risk forming deep vein thrombosis and pulmonary embolism than the general population[ncbi.nlm.nih.gov] […] interventions at the level of the body, conduct, health, and everyday life, received their color and their justification from the mythical concern with protecting the purity of the blood[books.google.com] From Wikidata Jump to navigation Jump to search type of hereditary blood disorder sickle-cell anemia drepanocytosis SCD SCA Sickle Cell Disease sickel cell disease sickle[wikidata.org] Other projects include Open Library & archive-it.org . Your use of the Wayback Machine is subject to the Internet Archive's Terms of Use .[web.archive.org] Currently, there are at least five major approaches for the general management of SCD and its complications.[ncbi.nlm.nih.gov]

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  • Bone Marrow Transplant

    Red blood cell transfusions were required until 118 days post-transplant.[ncbi.nlm.nih.gov] KEYWORDS: Histoplasma capsulatum; allogeneic bone marrow transplant; disseminated histoplasmosis; peripheral blood smear[ncbi.nlm.nih.gov] It has been hypothesized that transfusion induces subsequent BMT rejection through immunization.[ncbi.nlm.nih.gov] Our researchers have created exciting and new HSCT approaches for many rare diseases.[cincinnatichildrens.org] There are many types of HSCTs depending on the source of stem cells as described below: Autologous Stem Cell Transplantation: Autologous stem cell transplants are predicated[cumc.columbia.edu] For the stem cell collection, the donor is connected to a machine by a needle inserted in the vein (like for donating blood).[rarediseases.about.com] blood diseases.[nhlbi.nih.gov] However, all 4 subjects showed prevalence of CD20 CD27 memory B cells around 6 months posttransplant when B cell counts were still low and the clonal B cell repertoire very[ncbi.nlm.nih.gov] General characteristics of the Maroteaux-Lamy syndrome, such as a large head, a short neck, corneal opacity, an open mouth with macroglossia, enlargement of the skull and[ncbi.nlm.nih.gov] OBJECTIVES: Sickle cell anemia (SCA) and β -thalassemia major are well-recognized beta-globin gene disorders of red blood cells associated to mortality and morbidity included[ncbi.nlm.nih.gov]

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  • Exchange Transfusion

    The type and rate of complications in neonatal red cell alloimmune hemolytic disease exclusively are not clear.[ncbi.nlm.nih.gov] Peripheral oxygenation was unchanged. CONCLUSION: Partial exchange transfusion improves microcirculation in polycythemic newborns.[ncbi.nlm.nih.gov] We report a 26-day-old premature infant with chloroquine-resistant malaria who underwent exchange transfusion.[ncbi.nlm.nih.gov] In our opinion, this will lead to new postnatal therapeutic approaches for optimal TAPS management.[ncbi.nlm.nih.gov] Another difficulty that may be encountered when blood is administered rapidly under pressure is that of air embolism. autologous transfusion reinfusion of a patient's own[medical-dictionary.thefreedictionary.com] […] artery/vein (UA/V).[ncbi.nlm.nih.gov] The mean pre-ECT haematocrit of exchange transfused patients with whole blood and reconstituted blood was compatible.[ncbi.nlm.nih.gov] KEYWORDS: ARCET; iron overload; sickle cell disease[ncbi.nlm.nih.gov] Abstract Preoperative exchange transfusion is a routine practice in patients with sickle cell disease having elevated sickle cell hemoglobin levels ( 40%) undergoing open-heart[ncbi.nlm.nih.gov] Neonatal Partial Exchange Transfusion Calculator[en.wikipedia.org]

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  • Severe Aplastic Anemia

    Abstract The aim of this study was to evaluate the impact of pretransplant transfusion of packed red cells (PRCs) on outcome after allogeneic stem cell transplantation (SCT[ncbi.nlm.nih.gov] The combination of CY and TBI and the infusion of sufficient peripheral blood stem cells may contribute to the successful engraftment.[ncbi.nlm.nih.gov] Granulosit transfusions should not be avoided in patients who had an indication for. Copyright 2013 Elsevier Ltd. All rights reserved.[ncbi.nlm.nih.gov] Nonlinear mixed effect modeling approaches were used to develop a pharmacokinetic-pharmacodynamic model.[ncbi.nlm.nih.gov] To our best knowledge, this is the second published case of autologous SC transplant in sAA.[ncbi.nlm.nih.gov] Given through a tube inserted into a chest vein, the stem cells travel to the bone marrow and begin making new, healthy blood cells.[stjude.org] There is less experience in the utility of autologous cord blood transplantation, and there is great controversy about the role of autologous cord blood collection and storage[ncbi.nlm.nih.gov] Analysis of T cell subset chimerism showed that CD4 T cells were predominantly donor-derived at 1 year, whereas recipient-derived CD8 T cells shaped mixed chimerism with a[ncbi.nlm.nih.gov] View a list of open trials .[bmt.umn.edu] A total volume of red blood cell transfusion before deferoxamine therapy was about 96,000 mL.[ncbi.nlm.nih.gov]

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  • Splenectomy

    The spurious result appears to be related to red cell lysis resistance following splenectomy; however, this resistance appeared to be specific to the analytical method used[ncbi.nlm.nih.gov] Therefore it is uncertain if patients in whom platelet counts improved had peripheral thrombocytopenia.[nature.com] Splenectomy and blood transfusion, with their consequences, are the mainstay of long-term management used in different parts of the world.[ncbi.nlm.nih.gov] […] an Epstein-Barr virus associated inflammatory pseudotumor.1 , 2 CONCLUSION: Safe LPS requires systematic pre-operative assessment of hilar vascular anatomy and a stepwise approach[ncbi.nlm.nih.gov] Intraoperative autologous cell salvage was performed before hepatectomy. RESULTS: LSDH was successful in all patients. There was no conversion to open operations.[ncbi.nlm.nih.gov] vein junction.[archsurg.jamanetwork.com] As a result, these blood counts in splenectomised patients differ from reference values in the normal population.[ncbi.nlm.nih.gov] The levels of memory B- and T cells were compared by ELISPOT analysis.[ncbi.nlm.nih.gov] BACKGROUND AND OBJECTIVES: Patients undergoing synchronous open splenectomy and hepatectomy (OSH) for concurrent hepatocellular carcinoma (HCC) and hypersplenism usually have[ncbi.nlm.nih.gov] The observations of Jandl et al. 1 on body-surface scanning after the injection of red cells tagged with radioactive chromate (Cr 51 ) suggested that this technic might be[nejm.org]

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