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  • Tetracycline

    SUMMARY OF BACKGROUND DATA: To the authors' knowledge, spinal infection with Enterobacter agglomeranshas never been reported.[] KEYWORDS: Genetic modification in animals; Human telomerase reverse transcriptase; Immortalization; Sheep; Somatic cells; Telomerase repeat amplification protocol; Tetracycline-inducible[] Abstract With the introduction of Actisite (tetracycline hydrochloride) periodontal fiber therapy, controlled drug delivery of tetracycline into the periodontal pocket has[] KEYWORDS: Ledermix paste; allergy; root canal treatment; tetracycline; type 1 hypersensitivity[] The results demonstrate that the developed approach is highly cost-effective, simple and rapid. Copyright 2018 Elsevier B.V. All rights reserved.[] Further experiments revealed that PVT1 promoted cell proliferation and suppressed cell apoptosis.[] Abstract Tetracycline-regulated integrating vectors allow pharmacologically controlled genetic modification of murine and human hematopoietic stem cells (HSCs).[] PATIENTS AND METHODS: This open-label, randomized, controlled trial assessed the preventive effect of tetracycline for reducing afatinib-skin toxicities in NSCLC patients[] From 2008 to 2011, the STs of the isolates became more variable and introduction of genetically unrelated TRNG were noted.[] […] tetracycline transport [ PMID: 2168416 ], and that the region that includes the dipeptide plays an important role in metal-tetracycline transport; it perhaps acts as a gate that opens[]

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  • Congestive Heart Failure

    BACKGROUND: Spinal arteriovenous metameric syndrome (SAMS) is a combination of more than two separate vascular malformations in the same embryonic metameres.[] OBJECTIVE: To examine the differential influence of somatic-affective vs cognitive-depressive symptoms on HRQoL and behavioral functional capacity in CHF patients.[] INTRODUCTION: Left ventricular pseudoaneurysm caused by a transmural myocardial infarction is a fatal complication.[] CONCLUSION: The proposed three-step analytical approach enhanced predictive model performance for CHF readmissions.[] SELECTION CRITERIA: Eligible studies were randomised controlled trials comparing autologous adult stem/progenitor cells with no cells in people with chronic ischaemic heart[] TEVAR may be a good alternative to open surgery.[] Nevertheless, the results do suggest that heart rate plays a significant role in the progression of heart failure, and that the introduction of ivabradine may improve outcomes[] Various forms of congenital heart disease such as ventricular septal defect (VSD), patent ductus arteriosus (PDA) or common AV canal Heart valve disease caused by past rheumatic[] We present the case of a 52-year-old man who developed acquired thoracic aortic coarctation 30 years after a blunt trauma and deceleration injuries to the aorta requiring open[] The patient was managed in the intensive care unit and underwent open-heart surgery for mitral valve repair on postpartum day 3.[]

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  • Aspirin

    In the enclosed spinal canal, even a small space-occupying lesion may be rapidly symptomatic.[] Recently, mosaic or segmental overgrowth, a clinical condition caused by heterozygous somatic activating mutations in PIK3CA, was established as PIK3CA-related overgrowth[] INTRODUCTION: The antiplatelet effect of low-dose aspirin in patients with type 2 diabetes (T2DM) without cardiovascular disease (CVD) has not been thoroughly explored.[] However, those studies did not reflect contemporary approaches.[] We also evaluated the potential effects of aspirin on cell proliferation, invasion, migration, and apoptosis in two well-characterized OSCC cell lines (TCA8113 and CAL27).[] Aspirin inhibited xenograft tumor growth and reduced tumor cells stemness in nude mice.[] This study provides additional mechanistic rationale supporting clinical evidence and opens the perspective to identify individual poor responsiveness to drugs by specifically[] INTRODUCTION: Aspirin resistance (AR) has been reported to present after coronary artery bypass graft causing saphenous vein graft failure.[] The primary exposure of interest was low-dose aspirin, and all enrolled patients were provided open-label esomeprazole.[] INTRODUCTION: Aspirin overdose, though now infrequently encountered, nevertheless continues to contribute to significant morbidity and mortality.[]

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  • Fusobacterium Nucleatum

    This report describes a case of spinal cord compression caused by Actinomyces israelii with the coisolation of Fusobacterium nucleatum.[] Colorectal carcinogenesis represents a heterogeneous process with a differing set of somatic molecular alterations, influenced by diet, environmental and microbial exposures[] Additionally, F. nucleatum was able to secrete nucleic acids, and introduction of F. nucleatum RNA into PDLF led to a RIG-I-dependent activation of NF-κB.[] Imaging revealed lumbar canal stenosis and the presence of pyogenic liver abscesses from which Fusobacterium nucleatum and Streptococcus vestibularis were isolated.[] Hence, we aimed to predict drug target proteins in F. nucleatum, through subtractive genomics approach and host-pathogen protein-protein interactions (HP-PPIs).[] […] measured by fluorescence-activated cell sorter (FACS) analysis.[] Author information 1 ARQ Genetics, Bastrop, United States. 2 Harvard Stem Cell Institute, Cambridge, United States. 3 University of Virginia, Charlottesville, United States[] Bacterium aerogenes Bacterium aeruginosum Bacterium anitratum Bacterium anthracoides Bacterium bifidum Bacterium breve Bacterium bronchisepticus Bacterium buchneri Bacterium canale[] All of the detected proteases were inhibited by the serine protease inhibitor PMSF. analysis revealed that all of the detected proteases are encoded by genes encoding an open[] As well, we used computational approaches to predict and compare bacteriophage signatures across available sequenced F. nucleatum genomes. Crown Copyright 2015.[]

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  • Spinal and Bulbar Muscular Atrophy

    KEYWORDS: CAG/polyglutamine expansion; androgen receptor; neuromuscular disease; spinal and bulbar muscular atrophy; testosterone[] Testing of fetal tissues after elective pregnancy termination showed no somatic mosaicism in the CAG repeat length.[] INTRODUCTION: We investigated the long-term effects of leuprorelin on leg-muscle strength in spinal and bulbar muscular atrophy (SBMA).[] .- Secțiunea 3: Ion Canal tulburari. - Myotonic tip Duchenne 1, Steinert Disease.- congenitale Myotonic Dystrophy.- distrofie myotonic de tip 2, proximal Myotonic Myopathy[] Stem cells created from patient fibroblasts express less androgen receptor than control cells, but show androgen-dependent stabilization and nuclear translocation.[] INTRODUCTION: A reliable electrophysiological marker for clinical trials is increasingly needed in spinal and bulbar muscular atrophy (SBMA).[] Various therapeutic approaches have shown efficacy in mouse models, including androgen reduction and agents that alter the processing and degradation of the mutant androgen[] METHODS: We conducted open-ended interviews with 21 adult men with genetically confirmed SBMA.[] […] cancer development and progression, and SBMA with an aim to understand the underlying mechanisms involved in these diseases, which can be targeted for future therapeutic approaches[] We found that SBMA-iPSCs possess disease-specific biochemical features and could thus open new avenues of research into not only SBMA, but also other polyglutamine diseases[]

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  • Hypospadias

    KEYWORDS: Androgen receptor; CAG expansion; Hypospadias; Spinal bulbar muscle atrophy[] Moreover, our data indicate that somatically acquired idic(Y) can trigger mLOY, which usually appears as an aging-related phenomenon in elderly men. 2018 S.[] This was a common complication of gonorrhea before the introduction of antibiotics.[] Gov't MeSH terms Abnormalities, Multiple/genetics Abnormalities, Multiple/pathology Anal Canal/abnormalities* Base Sequence Child Chromosome Breakage Chromosomes, Human, Pair[] CONCLUSIONS: Guidelines to help standardize the surgical approach to severe hypospadias are needed.[] We present a case of advanced penile squamous cell carcinoma diagnosed 22 years after a childhood hypospadias repair with a free bladder mucosa graft.[] Author information 1 Pediatric Urology Research Center, Section of Tissue Engineering and Stem Cells Therapy, Pediatrics' Center of Excellence, Children's Hospital Medical[] Abstract Ejaculatory ducts draining into accessory urethral channel opening into perineum is rare.[] Read More In reproductive system disease: In the male …of the most common is hypospadias, in which the underside (ventral side) of the urethral canal is open for a distance[] Follow-up studies after delivery showed a normal cell line in lymphocytes with the trisomy appearing to be confined to the placenta.[]

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  • Malignant Mesothelioma

    Here we report a case of primary spinal malignant mesothelioma.[] […] mutations of PIK3CA in the endometrial cancer, and a somatic mutation of GNA11 and JAK3 in the PMM.[] INTRODUCTION: Metastatic mesothelioma to the oral cavity arises from the pleura or peritoneum and distant hematogenous metastases are seen in more than half of cases but only[] Abstract Paratesticular/scrotal and inguinal canal mass lesions in elderly patients may pose a diagnostic challenge to both the surgeon as well as the pathologist.[] […] highlight the current challenges associated with the diagnosis and treatment of mesothelioma and discuss how targeting miRNA may improve diagnostic, prognostic and therapeutic approaches[] Cancer stem cells (CSCs) are assumed to be responsible for initiating tumorigenesis and driving relapse after therapeutic interventions.[] Open lung biopsy In an open lung biopsy, your doctor will make a small incision between your ribs and remove a piece of your pleura.[] INTRODUCTION: Malignant mesothelioma of tunica vaginalis testis is an extremely rare tumour.[] Physical examination revealed a well-circumscribed, hard, non-reducible swelling palpable along the medial extent of the inguinal canal with no cough impulse.[] […] in combination with chemotherapy and immunotherapy or other therapeutic approaches.[]

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  • Neuroepithelioma

    Abstract A case of spinal cord tumour in a 41-year-old man is presented. The initial diagnosis was of metastatic small cell tumour.[] Abstract The recurrent translocation breakpoint on chromosome 22 of neuroepithelioma has been localized between two probes, D22S1 and D22S15, by both in situ hybridization and somatic[] Although introduction of wild-type p53 seems to be responsible for p21 induction, the overall protein levels of p53 were not induced.[] Similar tumours of the spinal canal have been described previously under a variety of names, in particular neuroepithelioma.[] Specific diagnosis and the current therapeutic approaches are discussed.[] Abstract The effects of cyclic nucleotide phosphodiesterase (PDE) inhibitors on cell proliferation of SK-N-MC human neuroepithelioma cell line was studied.[] It was concluded that the tumor was neuroepithelioma derived from a primitive stem cell of neural crest origin which possesses the bipotency to differentiate toward either[] Open biopsy was performed, and a diagnosis of peripheral neuroepithelioma was made. No genetic abnormalities were detected in the DNA obtained from the biopsy specimen.[] Cell nologies of DNA transfection and somatic cell fusion in the surface carbohydrates, cytoskeletal proteins, glycoproteins, exploration of molecular aspects of metastatic[] In this study, a morphometrical approach to this diagnosis is made by using nuclear (shape factors) and tissue (volume density of nuclei and stroma) parameters.[]

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  • Methylene Blue

    […] itself is characterized by a banded or beaded appearance. (5,6) Methylene Blue, Loefflers is also recommended for use in the staining of gram-negative bacteria found in spinal[] The reproducibility and generality of our strategy were acceptable by using somatic tumor cell lines.[] INTRODUCTION: Uterocutaneous fistula is an extremely rare clinical condition that can be seen after pelvic or uterine surgery.[] […] root canal.[] Targeting of mitochondrial dysfunction in various diseases has proven a successful approach, lending support to mitochondria as a pivotal player in TBI cell death and loss[] MB-PDT-induced autophagy modulated cell viability depending on the cell model used.[] Our study indicates the continuity of embryonic stem cells into adult prostate as organ-specific stem cells.[] CONCLUSIONS: The robot-assisted approach for bladder diverticulectomy is a viable alternative to both open and laparoscopic surgery.[] INTRODUCTION: Species of Streptococcus are classified based on their hemolytic properties into alpha and beta types.[] INTRODUCTION: The purpose of this study is to describe a case where methylene blue improved hemodynamics in a poisoned patient.[]

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  • Non-Hodgkin Lymphoma

    KEYWORDS: Cauda equina syndrome; chemo- and radiotherapy; lumbar; spinal tumour[] Additionally, we report the case of a child with NHL and a somatic 7q11.23 deletion.[] INTRODUCTION: We describe an autopsy-confirmed case of motor neuron disease with selective degeneration of the anterior horn cells associated with a non-Hodgkin lymphoma.[] Abstract Approximately 25% of all cases of extranodal non-Hodgkin lymphoma (NHL) occur in the head and neck region; NHL of the external auditory canal (EAC) and thyroid gland[] Abstract Autoantibody profiling with a systems medicine approach can help identify critical dysregulated signaling pathways (SPs) in cancers.[] Together, these findings demonstrate that BV6 and Bortezomib synergize to induce cell death in B-cell NHL cells.[] KEYWORDS: Autologous hematopoietic stem cell transplantation; B-cell non-Hodgkin lymphoma; Elderly patients; Mobilization[] This is a phase 2 prospective randomized (1:1) open-label single-institution noninferiority study of tbo-filgrastim and filgrastim with plerixafor in patients with MM or NHL[] INTRODUCTION: Primary lymphoma of the bone constitutes an extremely rare but distinctive clinical entity, accounting for approximately 3% of all primary bone malignancies[] There has been significant heterogeneity in the responses to these treatment approaches.[]

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