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  • Paroxysmal Nocturnal Hemoglobinuria

    Percutaneous thrombolysis is an efficacious treatment.[ncbi.nlm.nih.gov] The transfused red cells survive far longer than PNH cells.[nejm.org] He was given a second HRD-HSCT, but died from cytomegalovirus pneumonia after achieving hematopoietic recovery.[ncbi.nlm.nih.gov] While this therapeutic approach is effective, there is residual complement activity resulting from specific clinical scenarios as well as from upstream complement components[ncbi.nlm.nih.gov] CONCLUSIONS: This case represents the first report of acute bilateral central serous retinopathy associated with deferoxamine therapy.[ncbi.nlm.nih.gov] Retinal vein occlusion (RVO) is a frequent cause of vision loss but its relationship with PNH has not been studied systematically.[ncbi.nlm.nih.gov] , T-Cell, alpha-beta[ncbi.nlm.nih.gov] KEYWORDS: Hematopoietic stem cell transplantation; paroxysmal nocturnal hemoglobinuria; survival analysis[ncbi.nlm.nih.gov] […] understanding of the unique pathobiology of PNH in relationship both to complement physiology and immune-mediated bone marrow failure provides the basis for a systematic approach[ncbi.nlm.nih.gov] The patient exhibits biological signs of intravascular hemolysis, as well as a recent history of two episodes of deep vein thrombosis.[ncbi.nlm.nih.gov]

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  • Stem Cell Transplant

    The resulting sample could then be treated to further augment cell concentration and injected, under fluoroscopic control, into the non-union site through a percutaneous approach[ncbi.nlm.nih.gov] KEYWORDS: Bloodless; HSCT; Hematology-oncology; Hematopoietic stem cell transplantation; Transfusion; Transfusion-free[ncbi.nlm.nih.gov] KEYWORDS: fungemia; fusarium; hematopoietic stem cell transplant; skin lesion[ncbi.nlm.nih.gov] PURPOSE/OBJECTIVE(S): Craniospinal irradiation (CSI) improves local control of leukemia/lymphoma with central nervous system (CNS) involvement; however, for adult patients[ncbi.nlm.nih.gov] […] cares for children with all types of blood disorders, including: Sickle cell anemia Hemophilia (when the blood doesn’t clot) Bleeding Thrombotic disorders (problems with veins[pennstatehershey.org] Mantle cell lymphoma is a relatively rare malignancy, comprising fewer than 10% of all non-Hodgkin lymphomas.[ncbi.nlm.nih.gov] […] globulin followed by re-infusion of autologous stem cells as per standard institute protocol.[ncbi.nlm.nih.gov] This review summarizes background information about hematopoietic stem-cell transplantation and discusses the current role of the procedure.[nejm.org] If you don't already have a central line, one will be inserted in Interventional Radiology , or in the Operating Room.[franciscanhealth.org] These cells are then collected from the donor’s vein in a process called apheresis. Once collected, blood stem cells are delivered to the patient through a vein.[upmccancercenter.com]

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  • Aplastic Anemia

    KEYWORDS: Bare metal stent; Complications; Percutaneous coronary intervention; Subdural hematoma[ncbi.nlm.nih.gov] This is the second documented case of anti-AnWj to cause a hemolytic transfusion reaction.[ncbi.nlm.nih.gov] PURPOSE OF REVIEW: Improvements in allogeneic hematopoietic cell transplantation (HCT) with better donor selection, conditioning regimens and graft vs. host disease prophylaxis[ncbi.nlm.nih.gov] Diagnosis of AA requires a comprehensive approach with prompt evaluation for inherited and secondary causes of bone marrow aplasia, while providing aggressive supportive care[ncbi.nlm.nih.gov] While immune-mediated destruction of hematopoietic stem/progenitor cells (HSPCs) plays a central role in the pathophysiology of acquired AA, the transforming growth factor-β1[ncbi.nlm.nih.gov] Given through a tube inserted into a chest vein, the stem cells travel to the bone marrow and begin making new, healthy blood cells.[stjude.org] Abstract We report here the preliminary results of allogeneic hematopoietic stem cell transplantation with mesenchymal stem cells (MSCs) for 6 cases of severe aplastic anemia[ncbi.nlm.nih.gov] The bone marrow is the central portion of the bones that is responsible for making: Red blood cells, which carry oxygen White blood cells, which fight infection Platelets,[health.harvard.edu] Matched related donor allogeneic hematopoietic stem cell transplantation is the ideal pediatric treatment; alternative approaches include immunosuppressive therapy and use[ncbi.nlm.nih.gov] Red blood cells play a central role in the condition.[everydayhealth.com]

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  • Graft-versus-Host-Disease

    Percutaneous right mediastinal pleural biopsy confirmed recurrent thymoma (WHO type B3, Masaoka stage IVb).[ncbi.nlm.nih.gov] […] from blood relatives, intrauterine transfusions and HLA-matched platelet transfusions.[ncbi.nlm.nih.gov] Abstract A 30-year-old woman with myelodysplastic syndrome underwent allogeneic hematopoietic stem cell transplantation (HSCT) derived from her HLA-matched sister six years[ncbi.nlm.nih.gov] However, three new techniques are radically altering the approach to HSCT for those with no matched donor, particularly those with primary immunodeficiencies which are not[ncbi.nlm.nih.gov] Clinical, biological and radiological evidence suggested a diagnosis of central nervous system graft-versus-host disease (CNS-GvHD).[ncbi.nlm.nih.gov] So after high dose treatment, stem cells or bone marrow from a matched donor (also called a donor or an allogenic transplant) are given into a vein to replace those that the[bloodwise.org.uk] Alloreactive T cells infused with the stem cell inoculum may generate graft-versus-host disease (GVHD) representing one the most relevant obstacles to the successful outcome[ncbi.nlm.nih.gov] Abstract Graft-versus-host disease (GvHD) remains a major treatment-related risk in patients undergoing stem cell transplantation.[ncbi.nlm.nih.gov] BACKGROUND: Infection and graft-versus-host disease (GVHD) are among the most common complications after hematopoietic stem cell transplantation (HSCT).[ncbi.nlm.nih.gov] Approaches. . # Proceedings of the ... annual meeting of the Society of Biotherapeutic Approaches. a schema:Periodical ; schema:issn " 0250-7005 " ; schema:name " Proceedings[worldcat.org]

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  • Bone Marrow Transplant

    Percutaneous nephrostomy catheters were inserted in 5 patients for urinary diversion. All-cause mortality was 32.6% (N   14).[ncbi.nlm.nih.gov] It has been hypothesized that transfusion induces subsequent BMT rejection through immunization.[ncbi.nlm.nih.gov] High-intensity treatments and complications after hematopoietic cell transplantation (HCT) injure normal tissues and may increase the risk of frailty even among nongeriatric[ncbi.nlm.nih.gov] Our researchers have created exciting and new HSCT approaches for many rare diseases.[cincinnatichildrens.org] […] aim of this study was to determine whether a variation in practice from an aseptic non-touch technique (ANTT) to a sterile technique when changing needleless connectors on central[ncbi.nlm.nih.gov] For the stem cell collection, the donor is connected to a machine by a needle inserted in the vein (like for donating blood).[rarediseases.about.com] However, all 4 subjects showed prevalence of CD20 CD27 memory B cells around 6 months posttransplant when B cell counts were still low and the clonal B cell repertoire very[ncbi.nlm.nih.gov] Stem cell donation If it isn't possible to use your own stem cells for the transplant (see above), stem cells will need to come from a donor.[nhs.uk] Central vein catheterization: failure and complication rates by three percutaneous approaches. Arch Intern Med 1986 ;146: 259 - 261 7.[nejm.org] Abstract Cutaneous squamous cell carcinomas arise as secondary cancers in hematopoietic stem cell transplant survivors.[ncbi.nlm.nih.gov]

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  • Hematopoietic Stem Cell Transplantation

    […] the patient during treatment, such as hydration serum, antibiotics, chemotherapeutic drugs, blood transfusions and the actual infusion of hematopoietic stem cells, so that percutaneous[scielo.br] KEYWORDS: ABO incompatibility; Allogeneic hematopoetic stem cell transplantation; Blood group; Transfusion[ncbi.nlm.nih.gov] Allogeneic hematopoietic stem cell transplantation (allo-HSCT) still remains to be the curative treatment option for various non-malignant and malignant hematopoietic diseases[ncbi.nlm.nih.gov] Central nervous system lomentosporiosis is a rare pathological condition in immunocompromised patients.[ncbi.nlm.nih.gov] […] hepatic vein (P   0.015), hepatomegaly (P   0.001), gallbladder wall thickness (P CONCLUSIONS: The presence of reversed flow in portal vein, increased peak systolic velocity[ncbi.nlm.nih.gov] The time from diagnosis to transplant seems to influence negatively both OS (log-rank p KEYWORDS: Allogeneic stem cell transplantation; Cutaneous T cell lymphoma[ncbi.nlm.nih.gov] BACKGROUND: Proper stem cell mobilization is one of the most important steps in hematopoietic stem cell transplantation (HSCT).[ncbi.nlm.nih.gov] In patients with ST-segment elevation myocardial infarction, standard treatment, including percutaneous coronary intervention of the infarct-related artery with or without[dx.doi.org] Central nervous system (CNS) complications continue to be an important cause of morbidity and significantly contribute to mortality after HSCT.[ncbi.nlm.nih.gov] Thus, despite keen interest in these approaches, significant hurdles remain.[jci.org]

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  • Sickle Cell Disease

    He had spontaneous drainage of the abscess after spontaneous fistulisation, with the stomach obviating the need for percutaneous drainage. 2016 BMJ Publishing Group Ltd.[ncbi.nlm.nih.gov] […] who did not receive a transfusion.[ncbi.nlm.nih.gov] Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative therapy for sickle cell disease (SCD); however, its use is limited by lack of suitable[ncbi.nlm.nih.gov] The two cases presented here demonstrate that a team-based, multidisciplinary approach can facilitate a successful transition.[ncbi.nlm.nih.gov] In a chronic pain condition such as fibromyalgia central sensitisation is thought to play a key role.[ncbi.nlm.nih.gov] Patients with sickle cell disease have a baseline hypercoaguable state and are at a greater risk forming deep vein thrombosis and pulmonary embolism than the general population[ncbi.nlm.nih.gov] From Wikidata Jump to navigation Jump to search type of hereditary blood disorder sickle-cell anemia drepanocytosis SCD SCA Sickle Cell Disease sickel cell disease sickle[wikidata.org] Hematopoietic stem cell transplant is a curative option for SCD but less than 25% of patients have a suitable donor.[ncbi.nlm.nih.gov] Currently, there are at least five major approaches for the general management of SCD and its complications.[ncbi.nlm.nih.gov] Retinal vein occlusions also are rare with SCD. Chronic macular changes Chronic macular vascular occlusions occur in SCD.[emedicine.com]

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  • Amegakaryocytic Thrombocytopenia

    Acquired amegakaryocytic thrombocytopenic purpura induced by percutaneous ethanol injection during treatment of hepatocellular carcinoma: A case report.[jahjournal.org] Many patients become refractory to platelet transfusions even when HLA-matched.[ncbi.nlm.nih.gov] Initially, when the only hematological abnormality was isolated thrombocytopenia, the number of clonogenic BM hematopoietic progenitors was comparable to controls, including[ncbi.nlm.nih.gov] Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage.[books.google.com] The combination of CAMT and central nervous system abnormalities is uncommon.[ncbi.nlm.nih.gov] Varicose veins were observed in the lower esophagus, stomach, and rectum. Figure 2 Macroscopic and histopathological features of autopsy specimens.[wjgnet.com] When 2 X 10(5) of the patient's T cells were added to the culture system, the number of CFU-M decreased to only 3.5 /- 0.6/2 X 10(5) bone marrow cells.[ncbi.nlm.nih.gov] , for example, a more aggressive preparative regimen or an increased stem cell dose.[ncbi.nlm.nih.gov] Shimamura , Clinical approach to marrow failure , Hematology , 2009 , 1 , (329) , (2009) . Melissa J. Rose, Kathleen K. Nicol, Micah A. Skeens, Thomas G.[doi.org] The association of CAMT and central nervous system (CNS) abnormalities is uncommon.[ncbi.nlm.nih.gov]

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  • Thalassemia

    […] analysis for the known α-thalassemia variant; if the known α-thalassemia variant is present, globin chain synthesis analysis is performed using a fetal blood sample obtained by percutaneous[ncbi.nlm.nih.gov] In 9 patients with a β 0 /β 0 genotype or two copies of the IVS1-110 mutation, the median annualized transfusion volume was decreased by 73%, and red-cell transfusions were[ncbi.nlm.nih.gov] Abstract: Hematopoietic stem cell transplantation (HSCT) represents the only cure for patients with thalassemia.[doi.org] We tested this approach and identified the most responsive element for mediating splicing correction in engineered U7 snRNAs in HeLa-β E cell model cell line.[ncbi.nlm.nih.gov] We searched PubMed and the Cochrane Central Register of Controlled Trials (CENTRAL) through March 31, 2017 for articles related to thalassemia and BPs.[ncbi.nlm.nih.gov] More distinctive symptoms of this form include thrombosis of the deep veins, presenting as: leg thrombosis portal vein thrombosis stroke or embolism.[news-medical.net] Author information 1 a Department of Pediatrics , Shantou Central Hospital, Affiliated to Shantou Hospital of Sun Yat-Sen University , Shantou , People's Republic of China[ncbi.nlm.nih.gov] An intravenous (IV) catheter (flexible tube inserted into a vein) is placed in a large vein of the patient's neck, chest or arm for infusion of 5-azacytidine at a constant[clinicaltrials.gov] […] of the coupled approach TGA/Chemometrics, the Complete Blood Count (CBC) and Red Blood Cell (RBC) indices is developed and results are compared.[ncbi.nlm.nih.gov] Alpha thalassemia occurs frequently in people from Mediterranean countries, North Africa, the Middle East, India, and Central Asia.[rxlist.com]

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  • Busulfan

    A percutaneous needle liver biopsy revealed cellular cholestasis with focal liver cell necrosis accompanied by a mild inflammatory infiltrate.[ncbi.nlm.nih.gov] Abstract A patient with busulfan-induced pancytopenia and recurrent, thrombocytopenic bleeding was treated prophylactically with random-donor platelet transfusions and later[ncbi.nlm.nih.gov] Abstract Busulfan is an alkylating agent commonly used to ablate marrow before hematopoietic stem cell transplantation.[ncbi.nlm.nih.gov] The mathematical differences introduced by the application of different TDM approaches are not purely academic.[ncbi.nlm.nih.gov] […] nervous system lymphoma (PCNSL) or secondary central nervous system lymphoma (SCNSL), but it is associated with considerable toxicity and transplantation-related mortality[ncbi.nlm.nih.gov] It is a clear liquid that is injected slowly into a vein. Common Side Effects Hair loss is rare with busulfan. Colour or texture may change.[leukemiabmtprogram.org] The BuFlu group received more red blood cell transfusions (P   .02) and had a longer time to platelet recovery (P   .004).[ncbi.nlm.nih.gov] "Acute portal vein thrombosis after autologous stem cell transplantation". Bone Marrow Transplant. 18 (5): 949–53. PMID 8932850.[en.wikipedia.org] Platelet transfusion independence ( 20 10(9)/L) occurred at a median of 22.3 days (range, 11 to 60).[ncbi.nlm.nih.gov] The population was heterogeneous with regard to the indication for hematopoietic cell transplantation, donor type, stem cell source, and conditioning regimen.[ncbi.nlm.nih.gov]

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