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103 Possible Causes for Arginine, Demethylases, Histone

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  • Tranylcypromine

    Efficacy Antidepressant, Monoamine oxidase (MAO) inhibitor Target MAO [HSA: 4128 4129 ] [KO: K00274 ] Pathway hsa00260 Glycine, serine and threonine metabolism hsa00330 Arginine[kegg.jp] This approach employs tranylcypromine as a chemical scaffold for the design of novel demethylase inhibitors.[ncbi.nlm.nih.gov] Methylation is one such modification which may occur on both arginine and lysine residues.[dx.doi.org]

  • Kabuki Syndrome

    Sequencing revealed a n.476T G nucleotide transversion, predicting a non-conservative substitution of arginine for leucine at codon 159 (p.L159R).[ncbi.nlm.nih.gov] This study identifies KDM6A mutations as another cause of KS and highlights the growing role of histone methylases and histone demethylases in multiple-congenital-anomaly[ncbi.nlm.nih.gov] In vitro reporter alleles demonstrated a reduction in histone 4 acetylation and histone 3 lysine 4 trimethylation (H3K4me3) activity in mouse embryonic fibroblasts from Kmt2d[ncbi.nlm.nih.gov]

  • Weaver Syndrome

    […] methylate histone lysines, organism-specific biosystem (from REACTOME) PKMTs methylate histone lysines, organism-specific biosystem Lysine methyltransferases (KMTs) and arginine[ncbi.nlm.nih.gov] M0 MΦ were transfected with siRNA for histone 3 lysine 27 (H3K27) methyltransferase EZH2 or the H3K27 demethylase JMJD3 and/or stimulated with LPS IFNγ or IL-4 to drive M1[acrabstracts.org] histone H3 (H3K27).[ncbi.nlm.nih.gov]

  • Herpes Simplex Virus 1 Infection

    […] screen identified multiple enzymes predicted to influence HSV-1 replication, including argininosuccinate synthetase 1 (AS1), which consumes aspartate as part of de novo arginine[ncbi.nlm.nih.gov] […] pretreatment of cells with tranylcypromine (TCP), a drug widely used in the clinic to treat neurological disorders, restrains HSV-1 gene transcription by inhibiting the histone-modifying[ncbi.nlm.nih.gov] Histone marks around transcription start sites of HSV-1-induced and constitutively transcribed antisense transcripts are highly similar, indicating that the genetic loci are[ncbi.nlm.nih.gov]

  • X-linked Intellectual Disability Type Abidi

    A third family was also found to have a slightly more proximal missense mutation (p.R4063Q) which altered a highly conserved arginine in the HECT domain, which was likewise[bmjopen.bmj.com] The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature. 2007; 447(7144):601-5. doi: 10.1038/nature05823.[invitae.com] ID Support Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C.[autism.mindspec.org]

  • Circadian Rhythm

    Abstract We performed a quantitative investigation of arginine-vasopressin (AVP) immunopositive neurons in the suprachiasmatic nucleus (SCN), which is the endogenous clock[ncbi.nlm.nih.gov] Liver regeneration offers a distinctive opportunity to study cell proliferation in vivo Mammalian silent information regulator 1 (SIRT1), a NAD -dependent histone deacetylase[ncbi.nlm.nih.gov] JARID1a increased histone acetylation by inhibiting histone deacetylase 1 function and enhanced transcription by CLOCK-BMAL1 in a demethylase-independent manner.[sciencemag.org]

  • Progeria

    The most common mutation associated with this disease is a homozygous arginine 527 replacement by histidine.[doi.org] Cell lines from HGPS patients are characterized by multiple nuclear defects, which include abnormal morphology, altered histone modification patterns, and increased DNA damage[ncbi.nlm.nih.gov] […] farnesyltransferase inhibitor, trichostatin A was able to rescue normal heterochromatin organization while simultaneously reducing progerin levels. 57 In a similar vein, a histone demethylase[doi.org]

  • Doxorubicin

    The inhibition profile of doxorubicin-induced ROS by nicorandil was unaltered when an L-arginine derivative or a protein kinase G inhibitor was present.[ncbi.nlm.nih.gov] We show that anthracyclines promote histone eviction irrespective of their ability to induce DNA double-strand breaks.[ncbi.nlm.nih.gov] […] cells Zunyue Zhang , Guohong Lin , Yujing Yan , Xiang Li , Yibing Hu , Jing Wang , Bingjiao Yin , Yaqun Wu , Zhuoya Li & Xiang-Ping Yang Oncogene (2018) Assessing histone demethylase[doi.org]

  • T-cell Acute Lymphoblastic Leukemia

    This system transports cationic amino acids such as arginine and lysine out of the cell.[ncbi.nlm.nih.gov] KEYWORDS: TAL1; UTX; epigenetics; histone demethylase inhibitor; histone demethylation; leukemia[ncbi.nlm.nih.gov] Romidepsin is a potent, class 1 selective histone deacetylase inhibitor approved for the treatment of patients with peripheral T-cell lymphoma who have had 1 prior therapy[ncbi.nlm.nih.gov]

  • Idarubicin

    The model predicts that the amino sugar group of Doxo competes for space with the H4-arginine residue in the DNA minor groove.[doi.org] […] cells Zunyue Zhang , Guohong Lin , Yujing Yan , Xiang Li , Yibing Hu , Jing Wang , Bingjiao Yin , Yaqun Wu , Zhuoya Li & Xiang-Ping Yang Oncogene (2018) Assessing histone demethylase[doi.org] histone eviction.[doi.org]

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