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898 Possible Causes for Aryl, Hydrocarbon, Nuclear, Translocator

Did you mean: Aryl, hydrocarbons, Nuclear, Translocator

  • Retinoid

    Those two drugs act asimmunomodulators and potential activators of aryl hydrocarbon receptor.[tdx.cat] Basic Hydrocarbon The hydrocarbon ( 4 ), also known as axerophthene, should be designated deoxyretinol (see note).[sbcs.qmul.ac.uk] The promiscuous protein retinoid X receptor (RXR) displays essential allosteric regulation of several members in the nuclear hormone receptor superfamily via heterodimerization[ncbi.nlm.nih.gov] Karyotype analysis and RNA-Seq revealed the presence of a novel t(4;15)(q31;q22) reciprocal translocation involving the TMEM154 and RASGRF1 genes.[ncbi.nlm.nih.gov]

  • Infertility

    The association between aryl hydrocarbon receptor gene (AhR) polymorphism and male infertility risk remains conflicting.[ncbi.nlm.nih.gov] NR5A1 or steroidogenic factor 1 (SF1) is an autosomal gene, which encodes a protein that is a member of nuclear receptor family.[ncbi.nlm.nih.gov] Cytogenetic analysis of the couple showed a de novo chromosomal translocation t (2;11)(p14;q21) in the male partner and a normal 46, XX karyotype in the female counterpart[ncbi.nlm.nih.gov] Y-autosomal translocation has been previously reported in association with male infertility; however, the mechanisms of Y-autosomal translocation and non‑obstructive azoospermia[ncbi.nlm.nih.gov]

  • Novobiocin

    EGCG is known to inhibit the activity of many Hsp90-dependent client proteins, including telomerase, several kinases, and the aryl hydrocarbon receptor (AhR).[ncbi.nlm.nih.gov] On the other hand, novobiocin was disclosed to be a stimulator of [3H]acetate uptake and acted synergistically with butyrate in enhancing nuclear protein acetylation.[ncbi.nlm.nih.gov] […] could be disrupted by eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and by phospholipd scrambling of the cell membrane with phosphatidylserine translocation[ncbi.nlm.nih.gov] In addition, these changes were associated with an increased acetylation of nuclear proteins, especially those of DNase I sensitive nucleosomes.[ncbi.nlm.nih.gov]

  • Cassia

    Many recent studies have suggested that activation of the aryl hydrocarbon receptor (AhR) reduces immune responses, thus suppressing allergies and autoimmune diseases.[ncbi.nlm.nih.gov] Cytotoxicity, nuclear morphology and lactate dehydrogenase assays clearly show potent anticancer activity of the isolated compound against colon cancer.[ncbi.nlm.nih.gov] Furthermore, 2-MCA significantly increased HO-1 induction by translocation of Nrf-2 from cytosol to nucleus in endothelial cells.[ncbi.nlm.nih.gov] […] magnetic resonance spectroscopy (NMR). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, cytotoxicity, nuclear morphology and lactate dehydrogenase[ncbi.nlm.nih.gov]

  • Ginkgo Biloba Extract

    The aryl hydrocarbon receptor (AhR) signaling pathway regulates the production of CYP1B1 and CYP1A1, which catalyze the bioactivation of various procarcinogens.[ncbi.nlm.nih.gov] Immunofluorescent staining showed that there was AIF nuclear translocation in both EGb761-pretreated groups and OGD group, but AIF nuclear translocation was less in EGb761[ncbi.nlm.nih.gov] The use of chlorinated hydrocarbons in technical processes is very problematic because of the occupational medical risks, the potential danger of these compounds to the environment[google.com] Further, protein expression levels of PKC-α, ERK, nuclear factor-κB, and PPAR-γ were investigated by Western blotting.[ncbi.nlm.nih.gov]

  • Atopic Dermatitis

    IL-4 stimulation produced Ccl17 and Ccl22, which was attenuated by soybean tar Glyteer, a known aryl hydrocarbon receptor (Ahr) activator.[ncbi.nlm.nih.gov] May 2017 Elie Dolgin News and Views 16 December 2016 The relationship between atopic dermatitis and air pollution has been long debated but has now been connected via the aryl[nature.com] To investigate the influence of sweat components on the pathogenesis of AD, we performed a multifaceted assessment, including nuclear magnetic resonance spectroscopy-based[ncbi.nlm.nih.gov] JGJ inhibited nuclear translocation of the inflammatory transcription factors NFκB and STAT-1.[ncbi.nlm.nih.gov]

  • Prunella Vulgaris

    Rather, we found that its activities were probably related to an ability to function as an aryl hydrocarbon receptor (AHR) agonist in ECC-1 cells.[ncbi.nlm.nih.gov] PV suppressed VEGF and MMP-9 transcription by inhibiting activator protein (AP)-1 and nuclear factor-[Formula: see text]B (NF-[Formula: see text]B) activity.[ncbi.nlm.nih.gov] APV inhibited activation and translocation of nuclear factor kappa-B (NF-[Formula: see text]B) in HG-stimulated HMCs.[ncbi.nlm.nih.gov] APV induced Akt phosphorylation as well as activation of heme oxygenase-1 (HO-1), eNOS, and nuclear factor E2-related factor 2 (Nrf2), which may protect vascular inflammation[ncbi.nlm.nih.gov]

  • Acetaminophen

    Upregulation of Cyp1a2 primary transcript and mRNA in LKO mice correlated with the elevation of aryl hydrocarbon receptor (AHR) and mediator 1 (MED1), two transactivators[ncbi.nlm.nih.gov] Also, TA enhanced the mRNA expression of nuclear erythroid-related factor 2 (Nrf2) and its target genes.[ncbi.nlm.nih.gov] In addition, DADS inhibited the nuclear translocation of NF-κB and subsequent induction of inflammatory mediators.[ncbi.nlm.nih.gov] 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway was activated; however, APAP-induced c-Jun NH2-terminal kinase (JNK) activation, mitochondrial Bcl-2 Associated X Protein (Bax) translocation[ncbi.nlm.nih.gov]

  • Artemisia

    Recently, aryl hydrocarbon receptor (AHR), and its downstream transcription factor OVO-like 1 (OVOL1), have been shown to regulate the gene expression of FLG and LOR.[ncbi.nlm.nih.gov] Western blots revealed that Aa-EE reduced the expression of cytochrome c and cleaved caspase-3 and inhibited nuclear translocation of nuclear factor-kappa B (NF-κB), compared[ncbi.nlm.nih.gov] The mRNA expression of these inflammatory cytokine was also reduced via blocking nuclear factor-κB nuclear translocation by AS and DEQA.[ncbi.nlm.nih.gov] AAE regulates cytochrome c translocation to the cytoplasm and Bax translocation to the mitochondrial membrane in an Immunofluorescence staining and increase PTEN and p53 expression[ncbi.nlm.nih.gov]

  • Clofibrate

    Phenoxy compound Phenol ether Alkyl aryl ether Chlorobenzene Halobenzene Aryl chloride Aryl halide Carboxylic acid ester Carboxylic acid derivative Ether Monocarboxylic acid[hmdb.ca] The biological activity of peroxisome proliferators (PPs) is mediated by a class of receptors, known as PPARs (PP-Activated Receptor), belonging to the nuclear receptor superfamily[ncbi.nlm.nih.gov] A nuclear run-off assay and RT-PCR measurements of L-FABP mRNA revealed that clofibrate increased the L-FABP gene transcription rate.[ncbi.nlm.nih.gov] High level of coactivators steroid receptor coactivator-1 (SRC-1) and histone acetylase CBP-300 (CREB binding protein-300) were observed in the nuclear complexes of clofibrate[ncbi.nlm.nih.gov]