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9,410 Possible Causes for B, GABA, Interactions, Receptor, [MoA]

  • Dantrolene

    GABA (gamma-aminobutyric acid) content in CSF was remarkably increased. Therapeutically, dantrolene sodium was as effective as phenytoin or carbamazepine.[ncbi.nlm.nih.gov] […] and C. than 8% of dantrolene related compound B.[dx.doi.org] Verapamil , a calcium channel blocker, has the ability to decrease calcium influx and can interact with dantrolene to produce hyperkalemia and myocardial depression.[openanesthesia.org] Dantrolene, the primary drug to treat malignant hyperthermia, is a ryanodine receptor antagonist.[ncbi.nlm.nih.gov] MALIGNANT HYPERTHERMIA IN PATIENTS AT HIGH RISK Bioactivity Summary: scroll-- Target Class Pharos UniProt Action Type Activity value (-log[M]) Mechanism action Bioact source MoA[drugcentral.org]

  • Trimethadione

    Clorazepate Diazepam # Lorazepam # Midazolam Nimetazepam Nitrazepam Temazepam ; Others: Bromide ( potassium bromide , sodium bromide ) Imepitoin Paraldehyde Stiripentol GABA-T[en.wikipedia.org] […] insect cells than B-lymphoblast cells.[ncbi.nlm.nih.gov] Other drugs may interact with trimethadione, including prescription and over-the-counter medicines, vitamins, and herbal products.[everydayhealth.com] In a receptor binding study, trimethadione failed to inhibit flunitrazepam binding.[ncbi.nlm.nih.gov] […] exclusivity data (new drug applications) None Bioactivity Summary: scroll-- Target Class Pharos UniProt Action Type Activity value (-log[M]) Mechanism action Bioact source MoA[drugcentral.org]

  • Phenobarbital

    GABA Receptors Scientific Review Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure[tocris.com] HLA-B*1502 has also been demonstrated to be associated with carbamazepine-induced SJS-TEN.[ncbi.nlm.nih.gov] When the drug interactions of this case evaluated using the Drug Interaction Probability Scale, was assessed as "probable".[ncbi.nlm.nih.gov] […] of PhB to constitutive active androstane receptor (CAR, also known as NR1I3) typical of other xenobiotic-activated nuclear receptors has eluded detection.[ncbi.nlm.nih.gov] The MOA was evaluated using the modified Bradford Hill criteria for causality and other possible MOAs were excluded.[ncbi.nlm.nih.gov]

  • Cerebral Edema

    KEYWORDS: GABA; KCC2; NKCC1; brain development; cerebral edema; chloride; extracellular matrix; inhibition; seizures; traumatic brain injury[ncbi.nlm.nih.gov] Abstract We report a 48-year-old woman who developed convulsive seizures and cerebral atrophy after recovery from fulminant hepatitis B with coma and cerebral edema at the[ncbi.nlm.nih.gov] There was no significant interaction of recanalization and large core volume for any outcomes.[ncbi.nlm.nih.gov] Sulfonylurea receptor-1-transient receptor potential cation channel M4 is upregulated only after brain injury, causing edema in animal studies.[ncbi.nlm.nih.gov] […] maintenance of venous outflow, drainage of cerebrospinal fluid, hemicraniectomy Pharmacologic Mannitol Use: Reduce increased intracranial pressure due to cerebral edema MOA[strokecenter.org]

  • Tranylcypromine

    Tranylcypromine treatment leads to an up-regulation of GABA(B)-receptors and modulates the phospholipid metabolism, which is essential for normal brain function.[ncbi.nlm.nih.gov] Tranylcypromine (TCP) is an antidepressant originally known to target the monoamine oxidases A and B (MAO-A and MAO-B), which are structurally related to LSD1.[ncbi.nlm.nih.gov] A dangerous drug interaction could occur between tranylcypromine and certain other medications you used in the past 14 days.[emedicinehealth.com] […] at the rat and human dopamine D3 receptors, respectively, and displays respective selectivities of 10000-fold and 223-fold over the rat and human D2 receptors.[ncbi.nlm.nih.gov] Monoamine Oxidase Inhibitor I, Parnate, 2-PCPA, TCP, (1 R )-2-Phenylcyclopropan-1-amine, HCl, trans -2-Phenylcyclopropylamine, HCl, BHC110 Inhibitor V, LSD2 Inhibitor I, MOA[emdmillipore.com]

  • Mania

    Inverse findings for SICI (reduced) and LICI (increased) in BD indicate a possible differential involvement of the GABA A and GABA B subreceptor systems.[ncbi.nlm.nih.gov] Goodman, Brunton L, Chabner B, Knollman B (2011). Goodman Gilman's pharmacological basis of therapeuti (Twelfth ed.). New York: McGraw-Hill Professional.[en.wikipedia.org] To date, there are no known cases in the literature where this interaction has been described.[ncbi.nlm.nih.gov] For example: Standpoint Research's Ronnie Moas said in early July that bitcoin could possibly reach 5,000 "in a few months."[cnbc.com] […] favors greater 5HT2A receptor blockade and thus increases dopamine concentrations.[ncbi.nlm.nih.gov]

  • Ivermectin

    Our structures allow us to explore in detail the molecular recognition of ivermectin by GlyRs, GABA A Rs, and α7 nAChRs.[ncbi.nlm.nih.gov] This product is composed of both Ivermectin B 1a ( 90%) and Ivermectin B 1b . Deuterated analog also available.[rndsystems.com] Other drugs may interact with ivermectin, including prescription and over-the-counter medicines, vitamins , and herbal products.[emedicinehealth.com] We developed a Ca 2 -impermeable excitatory receptor by introducing the F207A/P-2'Δ/A-1'E/T13'V/A288G mutations and a Ca 2 -permeable excitatory receptor by introducing the[ncbi.nlm.nih.gov] Our results showed that chlorophacinone and ivermectin had distinct modes of action (MOA) in modulating FXR-coregulator interactions and compound selectivity against the four[ncbi.nlm.nih.gov]

  • Bumetanide

    […] to ligand-gated GABA(A) receptor-associated Cl() channels triggers Cl() efflux and depolarizing excitation.[ncbi.nlm.nih.gov] Bumetanide eradicated amphotericin B-induced reduction of formed clones and generated nucleosomes.[ncbi.nlm.nih.gov] DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects.[medicinenet.com] List the class for Bumetanide List the MOA for Bumetanide Inhibits the reabsorption of sodium and chloride in the ascending limb of the loop of henle List the indications[quizlet.com] Loop diuretics 24 flashcards Preview What is the MOA of Furosemide (loop diuretics)?[osmosis.org]

  • Acetylcholinesterase Inhibitor

    […] effects at nicotinic receptors, it affects not only cholinergic transmission but also other neurotransmitter systems such as monoamines, glutamate, and γ-aminobutyric acid (GABA[ncbi.nlm.nih.gov] Seven subjects underwent (11)C Pittsburgh compound B imaging within 12 weeks of magnetic resonance imaging.[ncbi.nlm.nih.gov] With increasing administration of acetylcholinesterase inhibitors for patients with Alzheimer's disease, practitioners should be aware of the potential for drug-drug interactions[ncbi.nlm.nih.gov] […] nicotinic receptors.[jstage.jst.go.jp] […] effector sites and ganglia therapeutic uses: -postoperative urinary retention and abdominal distension (neostigmine) -myasthenia gravis (pyridostigmine and neostigmine) MOA[flashcardmachine.com]

  • Levorphanol

    […] v t e GABA receptor modulators Ionotropic GABA A Agonists: ( )-Catechin Bamaluzole Barbiturates (e.g., phenobarbital ) BL-1020 DAVA Dihydromuscimol GABA Gabamide GABOB Gaboxadol[en.wikipedia.org] Interaction Checker Enter a drug name and levorphanol No Interactions Found Interactions Found Serious - Use Alternative Significant - Monitor Closely All Interactions Sort[reference.medscape.com] […] trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide (U50,488H) promoted internalization and phosphorylation of the FLAG-tagged human kappa opioid receptor[ncbi.nlm.nih.gov] Approvals: Date Agency Company Orphan Jan. 8, 1953 FDA VALEANT PHARM INTL FDA Adverse Event Reporting System None Pharmacologic Action: scroll-- Source Code Description FDA MoA[drugcentral.org] KEYWORDS: Analgesic; Kappa opioid receptor; Levorphanol; Mu opioid receptor; N-methyl-d-aspartate; NMDA; Opioid; Opioid rotation[ncbi.nlm.nih.gov]