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10,450 Possible Causes for B, activation, Anergy, cell, of, peripheral

Did you mean: B, amotivation, Anergy, cell, of, peripheral

  • Infectious Mononucleosis

    ABSTRACT Cultures were initiated with peripheral leukocytes from individuals: (i) in the acute stage of infectious mononucleosis (IM); (ii) with past histories of IM; and[jvi.asm.org] […] with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells.[ncbi.nlm.nih.gov] The mitogen responses were decreased and natural killer (NK) cell activity was low.[dx.doi.org] Our results indicate that EBV-infected CD8-positive cells and clonal proliferation of EBV-infected cells may be temporally detected in IM.[ncbi.nlm.nih.gov] […] for the expression of BZLF1, gp350, and the quantification of EBV DNA according to the 3 main subsets of peripheral blood B cells.[dx.doi.org] Cohen , Chronic Active Epstein–Barr Virus Disease , Frontiers in Immunology , 8 , (2017) .[dx.doi.org]

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  • Chronic Active Hepatitis B

    Abstract We have investigated in vitro proliferative responses of peripheral blood mononuclear cells and productions of interferon-gamma and soluble interleukin-2 receptors[ncbi.nlm.nih.gov] B.[ncbi.nlm.nih.gov] Abstract Reports on the histologic findings of chronic active hepatitis C (CAH-C) have been rare, and the characteristic histologic findings of CAH-C have been not yet determined[ncbi.nlm.nih.gov] […] reduced natural killer cell activity to the K562 cell target.[ncbi.nlm.nih.gov] This study delineates two major subgroups in CAH-B using peripheral T-cell phenotypes.[ncbi.nlm.nih.gov] active hepatitis B.[ncbi.nlm.nih.gov]

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  • Wiskott Aldrich Syndrome

    Four patients had no WASP expression in peripheral leukocytes obtained before bone marrow transplantation.[ncbi.nlm.nih.gov] […] found in autoreactive B cells.[ncbi.nlm.nih.gov] Although negative selection mechanisms including deletion, anergy, and receptor editing were relatively unperturbed, WASp-deficient transitional B cells showed enhanced proliferation[ncbi.nlm.nih.gov] Along with WASp, platelets express WAVE-2 as a physiologic activator of Arp2/3 complex and a small amount of N-WASp.[ncbi.nlm.nih.gov] METHODS: The TCR repertoire diversity in total peripheral T cells, sorted CD4( ) and CD8( ) T cells, and CD45RA( ) (CD45RA( )CD45RO(-) cells) and CD45RO( ) (CD45RA(-)CD45RO[ncbi.nlm.nih.gov] .: Lymphocyte-macrophage interaction in antigen induced in vitro lymphocyte transformation in patients with the Wiskott-Aldrich syndrome and other diseases with anergy.[link.springer.com]

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  • Adenosine Deaminase Deficiency

    The percentage of peripheral blood lymphocytes carrying the transduced ADA gene has remained stable at 10% to 20% during the 12 months since the fourth infusion.[ncbi.nlm.nih.gov] B cells.[ncbi.nlm.nih.gov] Expressed ADA activity of wild-type and mutant alleles ranged over five orders of magnitude.[ncbi.nlm.nih.gov] Thus, patients with ADA-SCID displayed measurable defects in peripheral airway that was detected by IOS and not spirometry.[ojrd.biomedcentral.com] Alterations in N-region insertions may contribute to the B-cell dysfunction associated with ADA deficiency.[ncbi.nlm.nih.gov] High levels of ADA activity was found in plasma, erythrocytes, and lymphocytes from patients with myeloid leukemia (p 0.001).[karger.com]

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  • Severe Combined Immunodeficiency

    […] blood leukocytes and buccal cells, from a 3-month-old boy and peripheral blood leukocytes from his parents.[ncbi.nlm.nih.gov] Abstract The management of patients with IL-7Rα deficient, T-B NK severe combined immunodeficiency (SCID) is a challenge in absence of adequate diagnostic and treatment modalities[ncbi.nlm.nih.gov] […] described, but pathological manifestations do not usually appear until later in life. 30 Lymphocyte proliferation studies confirm that lymphocytes are anergic and if there is anergy[doi.org] Linker for activation of T cells (LAT) is a transmembrane adaptor signaling molecule that is part of the TCR complex and essential for T-cell development, as demonstrated[ncbi.nlm.nih.gov] […] with Artemis-SCID cells.[ncbi.nlm.nih.gov] Laboratory studies confirmed the diagnosis of T-B-NK SCID and molecular studies revealed homozygous mutations in the RAG2 gene.[ncbi.nlm.nih.gov]

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  • Systemic Lupus Erythematosus

    […] performed a meta-analysis using the INMEX program (integrative meta-analysis of expression data) on publicly available microarray Genetic Expression Omnibus (GEO) datasets of peripheral[ncbi.nlm.nih.gov] […] of certain B cell responses in SLE.[ncbi.nlm.nih.gov] […] deficiency of Btk in mice is associated with a much milder phenotype. 37 B-cell–receptor signaling is important for establishing the B-cell repertoire through induction of anergy[nejm.org] Disease activity as measured by SLE Disease Activity Index (SLEDAI) did not significantly predict self-reported levels of fatigue.[ncbi.nlm.nih.gov] Impaired clearance functions for dying cells may explain accumulation of apoptotic cells in SLE tissues, and secondary necrosis of these cells may contribute to the chronic[ncbi.nlm.nih.gov] These three events include a breach in central tolerance in the adaptive arm of the immune system, peripheral amplification of the autoimmune response by the innate immune[ncbi.nlm.nih.gov]

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  • Graft-versus-Host-Disease

    Recent studies have revealed that HLA-identical sibling peripheral blood stem cell transplantation (PBSCT) had been providing impaired graft-versus-host disease (GVHD)-free[ncbi.nlm.nih.gov] […] disease (cGVHD) is mediated by specific CD4 and B cells, but the relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear.[ncbi.nlm.nih.gov] Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease . J. Clin. Invest. 109 , 549–557 (2002). 141.[doi.org] Here we discuss the aGVHD pathophysiology initiated by multiple signals that cause alloreactive T‐cell activation.[doi.org] Alloreactive T cells infused with the stem cell inoculum may generate graft-versus-host disease (GVHD) representing one the most relevant obstacles to the successful outcome[ncbi.nlm.nih.gov] […] reviews the literature data and reports one additional case of CIDP and GVHD, suggesting that the two clinical entities might share a similar immunological background. 2015 Peripheral[ncbi.nlm.nih.gov]

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  • Non-Hodgkin Lymphoma

    Electromyography showed peripheral nerve demyelination.[ncbi.nlm.nih.gov] Diffuse large B-cell lymphoma Diffuse large B-cell lymphoma (DLBCL) tends to grow quickly.[cancer.org] Blockade of suppressive programmed cell death 1 (PD-1) or CTLA-4 signaling has resulted in significant clinical activity by allowing intratumoral T cells to remain activated[ncbi.nlm.nih.gov] Together, these findings demonstrate that BV6 and Bortezomib synergize to induce cell death in B-cell NHL cells.[ncbi.nlm.nih.gov] Mature (peripheral) T-cell neoplasms: High-grade: Enteropathy-type T-cell lymphoma. Peripheral T-cell lymphoma. [ 3 ] Subcutaneous paniculitis-like. Systemic anaplastic.[patient.info] Activation of the phosphatidylinositol 3-kinase/mechanistic target of rapamycin pathway plays a role in the pathogenesis of non-Hodgkin lymphoma.[ncbi.nlm.nih.gov]

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  • Persistent Polyclonal B-cell Lymphocytosis

    A cell line derived from peripheral blood lymphocytes (PBL) of the patient was also analyzed.[ncbi.nlm.nih.gov] […] involved in B lymphocyte development.[ncbi.nlm.nih.gov] 18587574 ) Schmidt-Hieber M....Schwartz S. 2008 20 Persistent polyclonal B-cell lymphocytosis: a case report. ( 16988824 ) de Haan L.D....Pouwels J.G. 2006 21 Functional T-cell anergy[malacards.org] Serological findings suggested a chronic active Epstein-Barr virus (EBV) infection.[ncbi.nlm.nih.gov] […] patient: bcl-2/Ig gene rearrangements were found in blood mononuclear cells but not in lymphoma cells.[ncbi.nlm.nih.gov] Terminology Also known as persistent polyclonal B lymphocytosis (PPBL), B cell expansion with NFKB and T cell anergy (BENTA) Sites Peripheral blood, bone marrow May also involve[pathologyoutlines.com]

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  • Mycosis Fungoides

    In the late stages, the lymph nodes and viscera are affected A kind of skin cancer A peripheral (mature) t-cell lymphoma presenting in the skin with patches/plaques.[icd9data.com] Specific B-cell subsets, however, negatively regulate immune responses and are termed "regulatory B cells" (Bregs).[ncbi.nlm.nih.gov] Cells were analysed for response to inducers of apoptosis and cell-cycle arrest, using fluorescence-activated cell sorting.[ncbi.nlm.nih.gov] KEYWORDS: Large cell transformation; Mycosis fungoides; Oral cavity; Sezary syndrome; T-cell lymphoma[ncbi.nlm.nih.gov] BACKGROUND: Macrophages are classified into classically activated (M1) and alternatively activated (M2) macrophages.[ncbi.nlm.nih.gov] Activated T cells from his MF were likely a trigger factor for the development of his eosinophilic cellulitis.[ncbi.nlm.nih.gov]

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