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1,868 Possible Causes for BCL2, Clonal, Gene, Rearrangement

Did you mean: BCL2, clonus, Gene, Rearrangement

  • Formaldehyde

    Western blotting analysis was also applied for evaluating the expression of Bax and Bcl2 at protein level. Data were analyzed by student t and repeated measure tests.[ncbi.nlm.nih.gov] Clonal IgH gene rearrangement was documented by PCR in 38/46 follicular lymphomas using two alternative (FR3A and FR2A-based) primer systems: all benign hyperplasias showed[ncbi.nlm.nih.gov] (6 genes, 13 hits).[ncbi.nlm.nih.gov] KEYWORDS: Aza-Cope rearrangement; Cell imaging; Fluorescent probe; Formaldehyde; Toffee samples[ncbi.nlm.nih.gov]

  • Lymphoblastic Lymphoma

    Lymphomas showing both MYC/8q24 rearrangement and [email protected]BCL2/t(14;18)(q32;q21), also referred to as "double-hit" or "dual-hit" lymphomas (DHL) are rare B-cell malignancies with[ncbi.nlm.nih.gov] Furthermore, the 2 lymphomas were shown to be clonally related by clonality analysis and single-nucleotide polymorphism array analysis.[ncbi.nlm.nih.gov] We present a case of an infant with bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement.[ncbi.nlm.nih.gov] […] marrow (BM) and peripheral blood (PB) samples from a series of 65 children affected by T- (52) and B-lineage (13) LBL using an MFC method; 10 of them were also analyzed for clonality[ncbi.nlm.nih.gov]

  • B-Cell Chronic Lymphocytic Leukemia

    Southern blot analysis showed that the BCL2/IgJH rearrangement occurred at the major breakpoint region in the hot spot of the BCL2 gene.[ncbi.nlm.nih.gov] A clonal karyotype with two dicentric chromosomes, psu dic(12,21)(q24;q10) and dic(17,18)(p11.2;p11.2), was found. Both rearrangements were confirmed by FISH.[ncbi.nlm.nih.gov] […] in which none of them showed peripheral blood mononuclear cells positivity for fibromodulin gene expression (0%) (p-value 0.006).[ncbi.nlm.nih.gov] […] first time the molecular nature of these rearrangements.[ncbi.nlm.nih.gov]

  • Cyclosporine

    The mitochondrial proapoptotic molecule cyclophilin D, as well as Bcl2 expression also decreased after PBA treatment, paralleling an increase in cytochrome c expression.[ncbi.nlm.nih.gov] KEYWORDS: children; clonality; cytophagic histiocytic panniculitis; macrophage activation syndrome[ncbi.nlm.nih.gov] However, the effect of TGF-β1 and MDR1 gene polymorphisms on the pathogenesis of CsA-induced GO remains to be determined.[ncbi.nlm.nih.gov] Cyclosporine's anti-apoptotic activity in human gingival fibroblast is due to desensitization of mitochondrial permeability transition pore (MPTP) and augmentation of anti-apoptotic, Bcl2[ncbi.nlm.nih.gov]

  • Sertoli Leydig Cell Tumor

    Abstract A case of virilizing ovarian Sertoli-Leydig cell tumor overexpressing the BCL2 gene and including a novel clonal chromosomal rearrangement of chromosome 18, der(5[ncbi.nlm.nih.gov] By PCR, SLCT-derived genomic DNA lacked the SRY gene, indicating that the SLCT results from a SRY gene-independent pathway of pseudomale gonadal differentiation.[ncbi.nlm.nih.gov] Molecular characterization reveals the presence of genes specific for granulosa and Leydig cells; the relative expression of these genes, in addition to its histologic characteristics[ncbi.nlm.nih.gov] Abstract A case of virilizing ovarian Sertoli-Leydig cell tumor overexpressing the BCL2 gene and including a novel clonal chromosomal rearrangement of chromosome 18, der(5[ncbi.nlm.nih.gov]

  • T-cell Acute Lymphoblastic Leukemia

    KEYWORDS: T-ALL; ZBTB16-ABL1; fusion gene; gene mutation; transcriptome[ncbi.nlm.nih.gov] The drug combination caused AKT dephosphorylation and a downregulation of Bcl2, while nelarabine alone induced an increase in p-AKT and Bcl2 signaling in the resistant T-ALL[ncbi.nlm.nih.gov] JXG infiltrated lymph node biopsies and micro-dissected JXG histiocytes revealed an identical bi-allelic TCR-γ rearrangement in all samples, thus providing evidence for a clonal[ncbi.nlm.nih.gov] This is the first reported chromosomal translocation where AML1 is rearranged in childhood T-cell ALL.[ncbi.nlm.nih.gov]

  • Insect Bite

    The cells did not stain for bcl-1 protein and CD30, and with no evidence of clonality. The DIF test result was negative.[ncbi.nlm.nih.gov] […] insensitive to permethrin is discussed along with the surprising contrary clinical evidence from Europe about efficacy of permethrin in children with head lice carrying kdr-like gene[ncbi.nlm.nih.gov] Immunophenotyping, direct immunofluorescence (DIF) tests, and IgH gene rearrangement studies were performed in the lesions associated with MCL only.[ncbi.nlm.nih.gov] Immunophenotyping, direct immunofluorescence (DIF) tests, and IgH gene rearrangement studies were performed in the lesions associated with MCL only.[ncbi.nlm.nih.gov]

    Missing: BCL2
  • Composite Lymphoma

    Cloning and sequence analysis of the PCR products revealed a common clone-specific IgH gene rearrangement in these 2 lymphomas.[ncbi.nlm.nih.gov] No clonal relationship between the FL and CLL/SLL components was evident since the IGH-BCL2 rearrangement was present in in the former but not the latter.[ncbi.nlm.nih.gov] However, by employing a novel polymerase chain reaction-based technique for analysis of B-cell clonality, we show the persistence of a residual minor clonal B-cell population[ncbi.nlm.nih.gov] In other cases the transformed cells have the same clonal rearrangements as the CLL cells.[ncbi.nlm.nih.gov]

  • Ranitidine

    Pagina 558 - Interferon gamma: A secreted protein, known previously as immune interferon, that is produced according to the information coded by a species of interferon gene[books.google.ro] Ranitidine also prevented the down-regulation of B-cell CLL/lymphoma 2 (BCL2) and the up-regulation of BCL2-associated X protein (BAX) by rotenone.[ncbi.nlm.nih.gov] In vitro studies using clonal assays for hematopoietic progenitors revealed that while the patient's serum or ranitidine alone did not affect the patient's or normal bone[ncbi.nlm.nih.gov] […] model, and mathematically modeling our results, we hypothesize that this alteration in ligand mechanism of action is consequence of a change in ligand-induced conformational rearrangement[ncbi.nlm.nih.gov]

  • Burkitt Lymphoma

    The gene Deleted in Lymphocytic Leukemia 1 (DLEU1) is located in the region of 13q14.3.[ncbi.nlm.nih.gov] A subset of adult-mBL had BCL2 translocation and mutation and elevated BCL2 mRNA and protein expression, but had a mutation profile similar to mBL.[ncbi.nlm.nih.gov] […] and second BL lesions, which were found to be clonally distinct.[ncbi.nlm.nih.gov] Abstract Chromosomal translocations are acquired genetic rearrangements in human cancers.[ncbi.nlm.nih.gov]