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1,456 Possible Causes for BRCA1 A, complex

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  • Sinusitis

    Ang Luo, Kailun Zhang, Yanxia Zhao, Zhengmao Zhu, Liya Fu and Jin‐Tang Dong , ZNF121 interacts with ZBRK1 and BRCA1 to regulate their target genes in mammary epithelial cells[] NLD enlargement may favour osteomeatal complex obstruction, thus leading to severe acute sinusitis.[] Imaging revealed diffuse sinus opacification and a Le Fort type I complex fracture involving the maxilla, pterygoid plates, clivus, and right nasal bridge.[]

  • Endocrine Dysfunction

    Women who have inherited mutations in the BRCA1 or BRCA2 gene face a much higher risk of developing breast cancer and ovarian cancer compared with the general population.[] Gorovits , E , Tokareva , E , Khlynova , O et al. ( 2012 ) Complex evaluation of intestine microbiocenosis condition in patients with chronic pancreatitis .[] We conclude that the effects of endocrine dysfunction on bone density are complex and are both disease and site specific.[]

  • Malignant Neoplasm

    Andrieu N, Easton D, Chang-Claude J, et al.: Effect of chest x-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the international BRCA1/2 carrier cohort[] The complex role of radiation, cytotoxic drugs and genes in the development of a second malignant neoplasm in association with retinoblasma is also discussed.[] The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease.[]

  • Fanconi Anemia

    Consequently, while BRCA1 affects the accumulation of FANCD2 at sites of DNA damage, BRCA1/BARD1 E3 ligase activity is not essential for the monoubiquitination of FANCD2.[] […] and FANCI, and complex III member FANCJ.[] Given that HES1 interacts with members of the FA core complex, the aim of this study was to determine whether HES1 is mono-ubiquitinated via the FA core complex.[]

  • Papillary Serous Cystadenocarcinoma of the Ovary

    […] with patients with wild-type BRCA1 .[] The patient was a 16 year old girl, who was diagnosed with a complex cloacal anomaly at birth, requiring posterior sagittal anorectovaginourethroplasty, followed by further[] They are characterized by a filigree pattern of highly complex micropapillae arising directly from large, bulbous papillary structures.[]

  • LIG4 Syndrome

    MRN complex also promotes activation of ATM, which in turn activates several DNA repair factors as BRCA1/2. HR finishes with DNA synthesis and final ligation.[] […] size range anticipated for LIG4/XRCC4 complexes (data not shown).[] These findings highlight the importance of LIG4 in lymphocyte development and function, and in genomic stability maintenance, and provide a model for the complex phenotype[]

  • BRCA1-associated Hereditary Breast and Ovarian Cancer Syndrome

    BRCA1-associated BOCS is caused by pathogenic mutations in the BRCA1 gene.[] FILS syndrome) PPM1D Hereditary breast cancer PRF1 Aplastic anemia, adult-onset, Hemophagocytic lymphohistiocytosis, Lymphoma, non-Hodgkin PRKAR1A Acrodysostosis, Carney complex[] BRCA1 and BRCA2 Gene Mutations: Decision-Making Dilemmas Concerning Testing and Management.[]

  • Hereditary Breast Cancer

    In the absence of the FANCJ DNA helicase or its interaction with BRCA1, cells have defects in several aspects of the DNA damage response.[] BACKGROUND: Decision-making concerning risk-reducing mastectomy for women at hereditary risk of breast cancer entails complex personal choices.[] BRCA2 functions downstream of BRCA1 by complex-formation with RAD51.[]

  • Malignant Ovarian Neoplasm

    Most of the available information relates to BRCA1 -linked disease because BRCA1 germline mutations are approximately four times more common in ovarian cancer patients than[] A solid mass or complex mass (having both cystic and solid components) may be cancerous.[] These cancerous tumors require more complex treatment.[]

  • BRCA2-associated Hereditary Breast and Ovarian Cancer Syndrome

    BRCA1 and BRCA2 Gene Mutations: Decision-Making Dilemmas Concerning Testing and Management.[] Challenging and complex decisions in the management of the BRCA mutation carrier. J Womens Health (Larchmt). 2013;22:825-34. doi:10.1089/jwh.2013.4407.[] The other two mutations affect the BRCA1 gene.[]

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