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830 Possible Causes for BRCA2,, LEU2740TER

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  • Sunburn

    Tumor Growth Inhibition by Olaparib in BRCA2 Germline-Mutated Patient-Derived Ovarian Cancer Tissue Xenografts Clin. Cancer Res., February 15, 2011; 17(4): 783 - 791.[web.archive.org]

    Missing: LEU2740TER
  • Endocrine Dysfunction

    Women who have inherited mutations in the BRCA1 or BRCA2 gene face a much higher risk of developing breast cancer and ovarian cancer compared with the general population.[hormone.org]

    Missing: LEU2740TER
  • BRCA2-associated Hereditary Breast and Ovarian Cancer Syndrome

    BRCA2-associated BOCS is caused by pathogenic mutations in the BRCA2 gene.[symptoma.com] BRCA1 and BRCA2 Gene Mutations: Decision-Making Dilemmas Concerning Testing and Management.[labtestsonline.it] BRCA2 is a protein-coding gene.[symptoma.com]

    Missing: LEU2740TER
  • Hereditary Breast Cancer

    METHODS: The entire PALB2 coding region was sequenced in 409 breast/ovarian cancer patients negative for BRCA1 and BRCA2 mutations.[ncbi.nlm.nih.gov] RESULTS: Of the 349 probands analyzed, 21.5% were BRCA1/BRCA2 mutated, 65.3% at BRCA1 and 34.7% at BRCA2 gene.[ncbi.nlm.nih.gov] Abstract The relative contribution of heritable and nonheritable factors to disease expression in BRCA2 mutation carriers is largely unknown.[ncbi.nlm.nih.gov]

    Missing: LEU2740TER
  • BRCA1-associated Hereditary Breast and Ovarian Cancer Syndrome

    BRCA1 and BRCA2 Gene Mutations: Decision-Making Dilemmas Concerning Testing and Management.[labtestsonline.it] BRCA2 (BRCA2-associated BOCS), TP53 (Li-Fraumeni syndrome), PTEN (PTEN hamartoma tumor syndrome), CDH1 (hereditary diffuse gastric cancer), and STK11 (Peutz-Jeghers syndrome[symptoma.com] BRCA1 and BRCA2: Cancer Risk and Genetic Testing. Available online at through . Accessed November 2009.[labtestsonline.it]

    Missing: LEU2740TER
  • Familial Prostate Cancer

    We have evaluated immunohistochemical expression of BRCA2 protein and allelic loss of markers at the BRCA2 locus in tissue derived both from sporadic and from familial cases[ncbi.nlm.nih.gov] We identified one previously reported BRCA2 missense mutation and two previously unreported BRCA2 intron polymorphisms.[ncbi.nlm.nih.gov] In both cases, the wild-type allele was lost in the patient's prostate tumor at the BRCA2 locus.[ncbi.nlm.nih.gov]

    Missing: LEU2740TER
  • Fanconi Anemia

    Here we show that cell lines derived from FA-B and FA-D1 patients have biallelic mutations in BRCA2 and express truncated BRCA2 proteins.[sciencemag.org] Our results link the six cloned FA genes with BRCA1 and BRCA2 in a common pathway.[sciencemag.org] Functional complementation of FA-D1 fibroblasts with wild-type BRCA2 complementary DNA restores MMC resistance.[sciencemag.org]

    Missing: LEU2740TER
  • Familial Pancreatic Carcinoma

    BRCA2 protein.[ncbi.nlm.nih.gov] […] cationic trypsinogen gene, site-specific familial pancreatic cancer which may be due to the 4q32-34 mutation, hereditary breast-ovarian cancer (HBOC) syndrome that is due to BRCA2[ncbi.nlm.nih.gov] . : Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas . Cancer Res 1996, 56 :5360–5364. PubMed Google Scholar 3.[link.springer.com]

    Missing: LEU2740TER
  • Familial Congenital Mirror Movements 2

    Impairment of BRCA2 function has been associated with breat, ovarian, and other cancers.[weizmann.ac.il] BRCA2 binds RAD51 by eight highly conserved BRC peptide repeats that include two tetrameric amino acid motifs, i.e.[cordis.europa.eu] 19268590 PALB2 links BRCA1 and BRCA2 in the DNA-damage response Zhang, F , Ma, J , Wu, J , Ye, L , Cai, H , Xia, B , Yu, X Curr.[reactome.org]

    Missing: LEU2740TER
  • Malignant Ovarian Neoplasm

    - and BRCA2 -associated disease.[clincancerres.aacrjournals.org] Learn more about the genes involved, specifically the BRCA genes – BRCA1 and BRCA2.[mskcc.org] Glossary BRCA1 and BRCA2: Genes that function in the control of cell growth.[acog.org]

    Missing: LEU2740TER

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