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1,278 Possible Causes for C8a, box, homeo, protein,, zebrafish

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  • Mowat-Wilson Syndrome

    Mutation analysis of the zinc finger homeo box 1 B (ZFHX1 B) gene revealed a de novo 7 bp deletion (TGGCCCC) at nucleotide 1773 (1773 delTGGCCCC) resulting in a frameshift[ncbi.nlm.nih.gov] We used the zebrafish model system to determine whether zfhx1b has a role in vertebrate biliary development.[ncbi.nlm.nih.gov] This shortens protein from 1214 to 594 amino acids and affects the functionality of the critical ZEB2 protein.[ncbi.nlm.nih.gov] It is caused by mutations in the zinc finger homeo box 1B gene, ZFHX1B (SIP1). To date, 68 deletion/mutation-positive cases have been reported.[ncbi.nlm.nih.gov] Mowat–Wilson syndrome and mutation in the zinc finger homeo box 1B gene: a well defined clinical entity P Cerruti Mainardi 1 , G Pastore 1 , C Zweier 2 , A Rauch 2 1 Pediatric[jmg.bmj.com]

    Missing: C8a
  • Septo-Optic Dysplasia

    This rare developmental anomaly of midline brain structures can result from different pathogenetical events, including mutations of the homeo box gene HESX1, recently suggested[ncbi.nlm.nih.gov] […] and consistent with the clinical findings observed in our patients; a knockdown of TAX1BP3 causes elongation defects, enlarged pericard, and enlarged head structures in zebrafish[ncbi.nlm.nih.gov] Magnetic resonance imaging revealed thinned optic nerves, optic chiasma and pituitary infundibulum, absent septum pellucidum, box-shaped ventricles and right frontal cortical[mjdrdypu.org] A detailed picture of IGF-binding proteins is also presented.[ncbi.nlm.nih.gov] The hypoplastic septum pellucidum resulted in a box- like appearance of the frontal horns. It is difficult to see the pituitary stalk in the presented images.[slideshare.net]

    Missing: C8a
  • Rieger Syndrome

    PURPOSE: To report a case series of patients with novel forkhead box CI (FOXC1) mutations in a Korean family with Axenfeld-Rieger syndrome (ARS).[ncbi.nlm.nih.gov] RESULTS: Zebrafish pitx2 demonstrates conserved expression during ocular and craniofacial development.[ncbi.nlm.nih.gov] The mutation causes a frame shift after Thr44, the 7th amino acid of the homeo-domain, and introduces a premature stop codon in the gene sequence.[ncbi.nlm.nih.gov] Thus, wild type Pitx2 DNA binding activity is modulated by protein-protein interactions. We next studied two Rieger mutants.[ncbi.nlm.nih.gov] We screened the forkhead box C1 gene and the pituitary homeobox 2 gene in patients.[ncbi.nlm.nih.gov]

    Missing: C8a
  • Sunburn

    Flg promoter deletion and chromatin immunoprecipitation analysis showed that caudal type homeo box transcription factor 1 (Cdx1) was a key factor for Flg induction.[ncbi.nlm.nih.gov] One consequence of this is the synthesis of different proteins and enzymes.[scientificamerican.com] With a design that rivaled festivals like Tomorrowland and EDC – “comprised of 300 moving heads, 2500 sq feet of LED, more than 100 boxes of sound” – the fans were drawn to[youredm.com] Assessment [ 2 ] As for any burn - assess the severity and area covered (see box below). Examine the skin for colour change, blisters and capillary refill.[patient.info] […] to expression of erythema (4 h, p 0.001), neutrophil infiltration (24 h, p 0.01), epidermal COX-2 (24 h, p 0.05) and 12-LOX (24 h, p 0.01), and dermal eNOS (24 h, p 0.05) proteins[ncbi.nlm.nih.gov]

    Missing: C8a zebrafish
  • Premature Aging

    These are foods that come in a box or a can and have many ingredients that are hard to pronounce, containing food starches, gums, preservatives, and colorings.[boxingscene.com] In light of this, we have characterized telomerase-deficient zebrafish (Danio rerio) as the second vertebrate model for human telomerase-driven diseases.[ncbi.nlm.nih.gov] In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins.[ncbi.nlm.nih.gov] Our bioinformatics analysis identified the presence of a conservative E box element in the promoter regions of several genes encoding major antioxidant enzymes.[ncbi.nlm.nih.gov] In the present study, T cell receptor excision circles (TRECs), Forkhead-Box-Protein P3 gene (FOXP3) methylation of regulatory T cells (Tregs) and relative telomere lengths[ncbi.nlm.nih.gov]

    Missing: C8a homeo
  • Salmonella Infection

    , we determined that the phage-encoded GogB effector protein in Salmonella targets the host SCF E3 type ubiquitin ligase through an interaction with Skp1 and the human F-box[ncbi.nlm.nih.gov] Using knockdown analysis, we showed that this gene was downstream of the zebrafish homologs of the flagellin receptor TLR5 and the adaptor MyD88.[ncbi.nlm.nih.gov] RESULTS: Recombinant proteins representing the large extracellular domains of tetraspanins inhibited binding of S.[ncbi.nlm.nih.gov] Claudin is a member of the tight junction protein family, which has 24 members in humans.[ncbi.nlm.nih.gov] […] functional knockdown studies indicated that GogB-containing bacteria inhibited IκB degradation and NFκB activation in macrophages, which required Skp1 and a eukaryotic-like F-box[ncbi.nlm.nih.gov]

    Missing: C8a homeo
  • Monkeypox

    Box 218 Kinshasa XI, Democratic Republic of the Congo. [email protected] 10 U.S.[ncbi.nlm.nih.gov] […] both evaluate the efficacy of our antibodies and the applicability of the model system, marmosets were prophylactically treated with two monoclonal antibodies, c7D11 and c8A[ncbi.nlm.nih.gov] There are also differences in genes that code for virulence factors and host range proteins.[ncbi.nlm.nih.gov] To enhance the ability of researchers to study experimental MPXV infections, we inserted a gene encoding green fluorescent protein (GFP) into Monkeypox virus Zaire-79.[ncbi.nlm.nih.gov] Like other orthopoxviruses, MPV encodes a secreted chemokine binding protein, vCCI that is abundantly expressed and secreted from MPV infected cells.[ncbi.nlm.nih.gov]

    Missing: homeo zebrafish
  • Skeletal Dysplasia

    Electronic address: [email protected] 2 Department of Experimental Immunology, Academic Medical Centre, PO Box 22660, 1100 DD Amsterdam, the Netherlands; Department[ncbi.nlm.nih.gov] Interbreeding of the extl3 -mutant zebrafish ( box ) with Tg( rag2:green fluorescent protein ) transgenic zebrafish revealed defective thymopoiesis, which was rescued by injection[ncbi.nlm.nih.gov] She presented with protein-losing enteropathy in her 6th month. Post-mortem examination revealed lymphangiectasia in the small intestine.[ncbi.nlm.nih.gov] In zebrafish, for example, a DDRGK1 deficiency disrupts craniofacial cartilage development and causes a decrease in levels of the protein SOX9.[bcm.edu] , Tertiary Sequence Analysis, DNA Tibia/metabolism Substances DNA-Binding Proteins KIF22 protein, human Kinesin Supplementary concept Spondyloepimetaphyseal dysplasia with[ncbi.nlm.nih.gov]

    Missing: C8a homeo
  • Gastric Cancer

    KEYWORDS: FGFR2; HER2; RNA-helicase DDX6; gastric cancer MeSH terms, Substances MeSH terms Aged Aged, 80 and over Cell Line, Tumor DEAD-box RNA Helicases/genetics DEAD-box[ncbi.nlm.nih.gov] In addition, we summarize the current knowledge on the phylogeny and expression patterns of this family of genes in embryonic zebrafish and adult humans.[ncbi.nlm.nih.gov] Proline-rich protein 11 (PRR11) has been shown to be up-regulated in human cancers; however, its role in gastric CSCs is unknown.[ncbi.nlm.nih.gov] In addition, the data revealed that Neo1 positively regulated the expression of Zinc finger E-box-binding homeobox 1 (ZEB1) by activating the Rac1/PI3K/AKT pathway.[ncbi.nlm.nih.gov] Please see additional select Important Safety Information throughout, and the accompanying full Prescribing Information , including BOXED WARNINGS .[herceptin.com]

    Missing: C8a homeo
  • Vibrio Cholerae

    Box 2008, Bldg 1507, MS 6407, Oak Ridge, TN 37831-6407, United States. Electronic address: [email protected] 3 U.S.[ncbi.nlm.nih.gov] Here, we demonstrate how to assess V. cholerae-intestinal colonization in zebrafish and how to quantify V. cholerae-induced zebrafish diarrhea.[ncbi.nlm.nih.gov] Also, SlmA is a member of the TetR family of proteins, which are generally transcriptional repressors.[ncbi.nlm.nih.gov] , V. cholerae O-specific polysaccharide and lipopolysaccharide, toxin coregulated pilus A, sialidase, hemolysin A, flagellins (FlaB, FlaC, and FlaD), phosphoenolpyruvate-protein[ncbi.nlm.nih.gov] The putative αL motif of VcHsp15 shares a strikingly similar fold with several RNA binding proteins like ribosomal protein S4 and threonyl-tRNA synthetase.[ncbi.nlm.nih.gov]

    Missing: C8a homeo