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220 Possible Causes for CARD9

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  • Tinea Capitis

    Majocchi-like granulomas, deep ulcerated fungal infections, severe tinea capitis and corporis, and fungal nail involvement are characteristic of an inherited deficiency of CARD9[visualdx.com]

  • Troglitazone

    Furthermore, curdlan-mediated accumulation of caspase recruitment domain 9 (CARD9) in the cytosol was inhibited by TGZ.[ncbi.nlm.nih.gov] Our data demonstrate that the PPAR-γ ligand TGZ inhibits Dectin-1-mediated activation by interfering with CARD9, mitogen-activated protein kinase, and nuclear factor-κB signaling[ncbi.nlm.nih.gov]

  • Immunodeficiency due to MASP-2 Deficiency

    Channelopathies Due to Mutations in ORAI1 and STIM1 279 21 Deficiency of FOXN1 286 22 Chronic Mucocutaneous Candidiasis and Susceptibility to Fungal Infections Due to Defects in CARD9[books.google.com]

  • Paroxysmal Kinesigenic Dyskinesia

    In humans, there are four phylogenetically distinct CARD-CC family (CARD9, -10, -11 and -14) proteins and 9 true PKC isozymes (α to ι).[biorxiv.org]

  • Cryopyrin-Associated Periodic Syndrome

    Homozygous mutations in the CARD9 gene are associated with chronic mucocutaneous candidiasis.[allergycases.blogspot.com] Dysfunction of CARD9 impairs the innate signaling of dectin-1, an antifungal pattern-recognition receptor ( NEJM, 10/2009 ).[allergycases.blogspot.com]

  • Moraxella Catarrhalis

    KEYWORDS: CARD9; CEACAM3; COPD; Moraxella catarrhalis; Syk; granulocyte; immunoreceptor tyrosine-based activation motif (ITAM)[ncbi.nlm.nih.gov] The interaction of UspA1 with CEACAM3 induced the activation of the NF-κB pathway via Syk and the CARD9 pathway and was dependent on the phosphorylation of the CEACAM3 ITAM-like[ncbi.nlm.nih.gov]

  • Candida Albicans

    We detected a homozygous p.Q295X mutation in CARD9 as well as a defective interleukin-17 and interferon gamma synthesis in Enzyme-Linked ImmunoSpot tests.[ncbi.nlm.nih.gov] Molecular genetic analysis revealed a homozygous caspase recruitment domain 9 (CARD9) mutation (Q295X), which was reported to predispose to chronic mucocutaneous candidiasis[ncbi.nlm.nih.gov] Mice deficient in Dectin-1 or CARD9 are highly susceptible to disseminated candidiasis.[immunology.org]

  • Leprosy

    […] coding variants of exome-wide significance were discovered, including two rare variants: rs145562243 in NCKIPSD (P 1.71 10 -9 , odds ratio [OR] 4.35) and rs149308743 in CARD9[ncbi.nlm.nih.gov]

  • Familial Candidiasis 2

    Relevant External Links for CARD9 Genetic Association Database (GAD) CARD9 Human Genome Epidemiology (HuGE) Navigator CARD9 Atlas of Genetics and Cytogenetics in Oncology[genecards.org] Information by UniProt Database links Alternative names CANDF2 antibody CARD9 antibody CARD9_HUMAN antibody see all Western blot - Anti-CARD9 antibody [EPR6489] (ab133560)[abcam.com] [provided by RefSeq, Jul 2008] UniProt Comments for CARD9 CARD9: Activates NF-kappa-B via BCL10. Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2).[mybiosource.com]

  • Meningoencephalitis

    We detected a homozygous p.Q295X mutation in CARD9 as well as a defective interleukin-17 and interferon gamma synthesis in Enzyme-Linked ImmunoSpot tests.[ncbi.nlm.nih.gov] Therefore we sequenced CARD9 in the 5 patients.[ncbi.nlm.nih.gov] Abstract Caspase-associated recruitment domain-9 (CARD9) deficiency is an autosomal-recessive primary immunodeficiency with genetic defects in Th17 immunity marked by susceptibility[ncbi.nlm.nih.gov]

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