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42 Possible Causes for CD30, anti, immunotoxin

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  • Acute graft versus host disease

    Preclinical data demonstrate increased CD30 expression on activated CD8 T cells during aGVHD. Brentuximab vedotin (BV) is an antibody-drug conjugate targeting CD30.[ncbi.nlm.nih.gov] […] used in the experimental arm(s) were higher-dose steroids, antithymocyte globulin, infliximab, anti-interleukin-2 receptor antibody (daclizumab and BT563), CD5-specific immunotoxin[ncbi.nlm.nih.gov] To investigate the association between IL-22 and aGVHD, an anti-mouse IL-22 antibody (IL-22Ab) was used to ablate IL-22 activity in a mouse aGVHD model.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    The authors conducted a literature review of the MEDLINE database for articles in English concerning immunotoxins, BRAF inhibitors and BCR pathway inhibitors via PubMed.[ncbi.nlm.nih.gov] […] cytometric analysis demonstrated positivity for CD11a, CD11c, CD19, CD20, CD22, CD27, surface IgG, and λ but not for CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD21, CD23, CD25, CD30[ncbi.nlm.nih.gov] The patient was treated with immunosuppressive therapy including cyclosporine A and anti-thymocyte globulin (ATG).[ncbi.nlm.nih.gov]

  • Prolymphocytic Leukemia

    We also report epigenetically induced expression of the surface receptor protein CD30 in T-PLL.[ncbi.nlm.nih.gov] For HCL, your treatment plan may include rituximab and/or BL22 immunotoxin (see Targeted therapy, above).[cancer.net] After treatment with monoclonal anti-CD20 antibodies (rituximab) 375 mg/m(2) weekly for 4 weeks, complete remission was obtained.[ncbi.nlm.nih.gov]

  • Mycosis Fungoides

    Cerroni, 2007, p.13 Clinical trial number NCT00611208 for " A-dmDT390-bisFv(UCHT1) Immunotoxin Therapy for Patients With Cutaneous T-Cell Lymphoma (CTCL)" at ClinicalTrials.gov[en.wikipedia.org] He eventually developed a tumor on the hand, which was biopsied to reveal a dense dermal infiltrate of large lymphocytes (CD3 /CD4-/CD8-/TCR-BetaF1 /partial CD30 ).[ncbi.nlm.nih.gov] Tumours formed in mice from injected anti-miR-155-expressing MyLa cells had a significantly lower volume and higher occurrence of apoptosis than controls.[ncbi.nlm.nih.gov]

  • Interleukin-2

    Specifically, suppression of antitumor immune responses through CTLA-4 and CD30 were witnessed.[novusbio.com] The second patient was treated with denileukin diftitox, an immunotoxin fusion protein that targets the IL-2 receptor.[ncbi.nlm.nih.gov] Serum levels of anti-basiliximab IgE, assay of the anti-murine reactivity of circulating anti-basiliximab IgE, and assays for serum anti-mouse antibodies and global anti-basiliximab[ncbi.nlm.nih.gov]

  • Germ Cell Tumor

    These atypical epithelial cells were positive for CD30, pan CK, AFP, β-HCG and CD 117, thusprocuring a diagnosis of mediastinal mixed germ cell tumor.[ncbi.nlm.nih.gov] Therapies like immunotoxins, which include anti-cancer drugs attached to antibodies specific to tumor cells, and other ways of making drugs more specific for tumor cells,[encyclopedia.com] When thrombosis is detected during anti-cancer chemotherapy, we must investigate whether the presence of thrombosis is systemic or local.[ncbi.nlm.nih.gov]

  • T-Cell Lymphoma

    Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments. Clin Cancer Res . 2002 ; 8 : 2345 -2355. Moura IC, Lepelletier Y, Arnulf B, et al.[bloodjournal.org] No differences were observed in almost all clinical characteristics between CD30-positive cases and CD30-negative cases.[ncbi.nlm.nih.gov] Laboratory findings revealed hepatic dysfunction and positivity for anti-mitochondrial M2 antibody (AMA-M2).[ncbi.nlm.nih.gov]

  • Lymphoproliferative Disorder

    Unexpectedly, a CD30 lymphoproliferative disorder was diagnosed; subsequently the tumor spontaneously resolved.[ncbi.nlm.nih.gov] Complete sustained response of a refractory, post-transplantation, large B-cell lymphoma to an anti-CD22 immunotoxin. Ann Intern Med. 1997;126:882.[transplantbuddies.org] Twenty percent to 40% of de novo diffuse large B-cell lymphomas (DLBCLs) express CD30, and some patients have been treated with the anti-CD30 agent brentuximab.[ncbi.nlm.nih.gov]

  • Multiple Myeloma

    The effectiveness of the immunotoxin can be further increased by stimulating CD38 expression using retinoid acid.[stemcell.com] Anno: 2006 - ISBN: Titolo Immunoexpression of the CD30 ligand/CD30 and IL-6/IL-6R signals in thyroid autoimmune diseases.[polime.it] This article summarizes the more recent literature data concerning the employment of anti-angiogenic therapeutic agents actually used in preclinical models and clinical settings[ncbi.nlm.nih.gov]

  • Classic Hodgkin Lymphoma

    ., Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies, J Clin Oncol, 2000;18(8):1622–36.[touchoncology.com] Herein, we show involvement of cHL hallmark antigen CD30 in this process.[ncbi.nlm.nih.gov] Anti-tumor activity and expression of immunomodulatory proteins in tumor biopsies were the main secondary endpoints.[healio.com]