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4,557 Possible Causes for CDC25, Ras specific, exchange, factor, nucleotide

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  • Sulindac

    It impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. It is an active metabolite of sulindac.[] […] receptor (EGFR), cyclin D1, p65 subunit of NFκB and vascular endothelial growth factor (VEGF).[] Ten single-nucleotide polymorphisms (SNPs) were genotyped, and plasma sulindac sulfide concentrations were measured at 0, 1.5, 4, and 10 hours after drug administration.[] Inhibits Ras signaling.[] In retrospect, I think that for me, the Sulindac was a trade-off: less stomach irritation exchanged for liver irritation with the Sulindac.[]

  • Osteoporosis

    […] between the International Osteoporosis Foundation and the National Osteoporosis Foundation of the USA, Osteoporosis International provides a forum for the communication and exchange[] The aim of this study was to identify factors associated with osteoporosis treatment in postmenopausal women.A cross-sectional study was carried out from March to August 2013[] We aimed to perform a meta-analysis to assess the association of three IGF-1 single nucleotide polymorphisms (SNPs) rs35767, rs2288377, and rs5742612 with osteoporosis risk[] Chromosomal single nucleotide polymorphism (SNP) microarray using buccal cells confirmed the previous result with mosaicism estimated at 59% of cells.[] Abstract Osteoporosis or osteopenia is a common complication in patients with cirrhosis, but little is known about the risk factors for the occurrence of osteoporosis.Patients[]

    Missing: CDC25 Ras specific
  • Factor XI Deficiency

    KEYWORDS: Factor XI; acquired inhibitor; therapeutic plasma exchange[] Factor XI functions as a serine protease and activates factor IX, which, together with factor VIII activates factor X.[] Gene sequencing for FXII revealed a C46T in the promoter region and a deletion mutation of two nucleotides CA at position 9160 and 9161 in exon 5.[] DNA sequence analysis of the factor XI gene revealed a novel T to A mutation at nucleotide 168 resulting in the substitution of the cysteine residue at codon 38 with a stop[] […] products from his factor XI gene revealed a G to T transversion in exon 12, resulting in the nonsense mutation (Glu447Stop) and a G insertion in five consecutive guanine nucleotides[]

    Missing: CDC25 Ras specific
  • Hypofibrinogenemia

    Plasma exchange donation is a practical alternative source for cryoprecipitate.[] This study reports on a 25-year-old patient with hypofibrinogenemia (fibrinogen 0.6 g/l) and congenital thrombophilia due to heterozygous factor V Leiden mutation who developed[] The mRNAs amplified with RT-PCR were analyzed by agarose gel electrophoresis and nucleotide sequencing.[] Anti-cyclic citrullinated peptide (CCP) antibodies are considered highly specific for RA and are directed against various citrullinated antigens, including citrullinated fibrinogen[] This mutation causes the amino acid exchange 313 Ser-- Asn in the gamma chain.[]

    Missing: CDC25
  • Factor X Deficiency

    Abstract In patients with rare factor deficiencies, for which no factor concentrates are available, plasma exchange (PE) is an option for raising the desired factor level[] […] directly tests factor X.[] Direct DNA sequencing was used to detect a previously identified factor X mutation, and linkage analysis using a single nucleotide polymorphism (SNP) was used to follow the[] The complete nucleotide sequences of all exons and exon/intron junctions of the patient's genomic DNA revealed a homozygous G[] Factor X was provided prior to delivery for the first time in pregnancy via plasma exchange.[]

    Missing: CDC25 Ras specific
  • Adrenocortical Carcinoma

    We identified a transcriptional regulatory mechanism involving increased abundance of VAV2, a guanine nucleotide exchange factor for small GTPases that control the cytoskeleton[] The drugs have targeted the insulin-like growth factor receptor 1, TOP 2, polo-like kinase1, cyclin-dependent kinase inhibitors, p53 reactivation and CDC25. 2018 European[] RESULTS: A germline BRCA2 2 bp heterozygous deletion at nucleotide 8765 (8765delAG) leading to a frameshift mutation (p.Glu2846GlyfsX23) was detected.[] , PKC), inhibition of apoptosis, or changes in various adrenocortical tissue-specific factors (eg, the steroidogenic acute regulatory protein (StaR)) are possible.[] Single nucleotide polymorphism array profiling of adrenocortical tumors—evidence for an adenoma carcinoma sequence? PLoS ONE 8 , e73959 (2013). 23. Barreau, O. et al.[]

  • Streptococcal Infection

    Complement gene screening revealed a heterozygous single nucleotide insertion in exon 4 of the complement factor H-related protein 5 gene (CFHR5), resulting in a premature[] Out of these two, anti-CCP2 antibody is supposed to be more specific for RA.[] (Study describing management aspects of severe group A streptococcal infections, including the potential utility of plasma exchange) Rodríguez-Nuñez, A, Dosil-Gallardo, S,[] The amino acid and the nucleotide sequences of the isolated protein revealed to be highly identical to those of reported plasmin(ogen) receptor of GAS.[] Spread of strep bacteria via food borne transmission is less common than direct person-to-person exchange of droplets or saliva.[]

    Missing: CDC25
  • Helicobacter Pylori

    The data show extensive bidirectional exchange of DNA between the strains isolated from the family members, illustrating both the convergence and divergence effect that recombination[] The presence of 2143G, which was associated with previous eradication history and female sex, was an independent risk factor for eradication failure.[] This study aimed to investigate the relationship between single nucleotide polymorphisms (SNP) rs3804099 in the TLR2 gene and rs4986790 in the TLR4 gene with H. pylori infection[] Single nucleotide variants (SNVs) were extracted and analyzed from multidrug efflux transporter genes.[] METHODS: This was a case-control study in which upper gastrointestinal endoscopy, gastric histology, Helicobacter pylori testing, and risk factor questionnaires were obtained[]

    Missing: CDC25 Ras specific
  • Nephrogenic Systemic Fibrosis

    Small case reports have been published illustrating moderate treatment success with therapeutic plasma exchange (TPE).[] These cells express fibroblast growth factor (FGF)23, osteoblast transcription factors Runt-related transcription factor 2, and osterix, and show an osteogenic phenotype in[] METHODS: We examined whether an intronic single-nucleotide polymorphism (SNP) in caveolin-1 (CAV1 rs4730751) and 2 coding SNPs in transforming growth factor-beta 1 (TGFB1[] High WA, Ayers RA, Cowper SEJ (2007) Gadolinium is quantifiable within the tissue of patients with nephrogenic systemic fibrosis.[] CONCLUSION: Chronic liver disease does not appear to be a significant risk factor for NSF. 2014 Wiley Periodicals, Inc.[]

    Missing: CDC25
  • Factor IX

    Abstract Recently, a pure factor IX concentrate, licensed in Sweden as Immunine, was prepared through ion exchange and hydrophobic chromotography.[] This antibody was found to bind to a common metal-ion-dependent conformational epitope found on the γ-carboxyglutamic acid (Gla) domain of prothrombin, factor X and factor[] Herein we report a novel missense mutation at the nucleotide position 30829-T A in the exon 8 of factor IX gene.[] The results showed an increase in the F1 2 levels after the factor IX injection, but an increase lower than previously observed with an ion-exchange chromatography-purified[] These results strengthen the evidence for the importance of nucleotide -26, both for the normal transcription of the gene in response to HNF4 and for the proposed Leyden recovery[]

    Missing: CDC25 Ras specific