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15 Possible Causes for Calmodulin Dependent, Kinase,, Multiprotein

  • Cardiac Hypertrophy

    RNA, Long Noncoding/genetics* Rats Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction TOR Serine-Threonine Kinases/metabolism Substances Multiprotein[] Myosin light chain kinase (MLCK), a specific kinase for the phosphorylation of myosin light chain 2 (MLC2), plays an important role in regulating cardiac muscle contraction[] […] of β-arrestin2 with both TβRIII and calmodulin-dependent protein kinase II.[]

  • Carbachol

    Under elevated [Ca(2 )]i conditions, PLC-γ scaffolds c-Src into NHE3-containing multiprotein complexes before dissociation of PLC-γ from NHE3 and subsequent endocytosis of[] […] to protein kinase C (PKC) zeta, and by the p70S6K inhibitor rapamycin.[] There are many Ca 2 -requiring mediators that could be involved in carbachol-induced dispersion, including the Ca 2 -calmodulin-dependent protein phosphatase calcineurin.[]

  • Long QT Syndrome

    Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin . Circ. Res. 99 , 407–414 (2006). 31. Tester, D.[] In this article, we review evidence supporting another cause of aLQTS due to inhibition of phosphoinositide 3-kinase (PI3K) signaling.[] The underlying basis of this form of LQTS is a disruption of Ca 2 /calmodulin (CaM)-dependent inactivation of L-type Ca 2 channels.[]

  • Autosomal Dominant Non-Syndromic Intellectual Disability

    In stable multiprotein complexes, like WASH or the analogous Wasp family, verprolin homology domain-containing protein complex, which plays a similar role in activating Arp2[] II alpha 18 56,193,978 56,295,869 RGD:8554872 RGD:13592920 autosomal dominant mental retardation 54 G Camk2b calcium/calmodulin-dependent protein kinase II beta 14 86,208,876[] […] syndrome GTPase-activating protein guanosine nucleotide dissociation inhibitor guanosine diphosphate guanosine triphosphate guanosine triphosphatase mitogen-activated protein kinase[]

  • Familial Mediterranean Fever

    The function of pyrin has not been completely elucidated, but in short, it is a protein that binds to the adaptor ASC and the pro form of the enzyme caspase-1 to generate multiprotein[] After 2 months, he presented with severe myopathy and elevated creatine kinase.[] The large subunit contains the catalytic function and a calmodulin-like domain that can bind to the PEST domain of IκB-α for proteolytic cleavage. 58 Calpain-mediated cleavage[]

  • Achalasia - Microcephaly Syndrome

    NPCs as large, multiprotein complexes span the nuclear envelope (NE) by forming a selective channel between the cytoplasm and nucleus.[] […] hot topics in endocrinology, including endocrine disruptors, bariatric surgery, androgen deficiency, genetic causes of obesity, endocrine rhythms, and the use of tyrosine kinase[] dependent serine protein kinase calcium/calmodulin-dependent serine protein kinase (MAGUK family) CAMGUK, drosophila, homolog of trinucleotide repeat containing 8 vertebrate[]

  • Congenital Generalized Lipodystrophy Type 4

    Cavin-1 is an abundant protein component of caveolae, and member of a family of related proteins that form a caveola- associated multiprotein complex.[] Here, we describe the youngest Japanese case of CGL4-a Japanese girl with asymptomatic high serum creatine kinase (CK) levels at 3months old.[] 1 (phosphorylase kinase, delta) CALR calreticulin CAMK1D calcium/calmodulin-dependent protein kinase ID CAMK2D calcium/calmodulin-dependent protein kinase II delta CAMK2G[]

  • Hypoinsulinemic Hypoglycemia and Body Hemihypertrophy

    By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse[] (v-akt) homolog-2, protein kinase Akt-2, protein kinase B beta, putative v-akt murine thymoma viral oncoprotein 2, rac protein kinase beta, v-akt murine thymoma viral oncogene[] Expressed in skeletal muscle.protein kinaseCalcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2 )/calmodulin-binding and autophosphorylation,[]

  • Autosomal Recessive Ataxia Type Beauce

    These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX[] […] protein ligase MAP3K5 mitogen-activated protein kinase kinase kinase 5 MAP3K7 mitogen-activated protein kinase kinase kinase 7 MAP4 microtubule-associated protein 4 MAP7D1[] dependent serine protein kinase calcium/calmodulin-dependent serine protein kinase (MAGUK family) CAMGUK, drosophila, homolog of trinucleotide repeat containing 8 vertebrate[]

  • Glycogen Storage Disease due to Hepatic Glycogen Synthase Deficiency

    Pyruvate dehydrogenase (PDH) is a multiprotein complex that catalyses the irreversible oxidative decarboxylation of pyruvate to acetyl-CoA in the mitochondrial network, whereas[] kinase regulatory subunit, gamma 2 phosphorylase kinase, gamma 2 (testis) phosphorylase kinase, testis/liver, gamma-2 PHKG2 172471 8931[] Additional responses to calcium are the activation of members of the calmodulin-dependent protein kinase family identified as CaMK2 (Ca 2 /calmodulin-dependent kinase 2; also[]