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479 Possible Causes for Carbonyl, Reductases

  • Influenza

    This restoration of pH occurs much more slowly than the re-alkalinization of cells treated with the protonophore carbonyl cyanide p -trifluoromethoxyphenylhydrazone ( 27 )[doi.org] Immune-mediated necrotizing myopathy may be associated with myositis-specific autoantibodies including anti-single recognition particle and anti-3-hydroxy-3- methylglutaryl-coenzyme A reductase[ncbi.nlm.nih.gov] The acetyl carbonyl oxygen forms a hydrogen bond with the hydroxyl group of Y231 (ICV HEF: Y227).[doi.org]

  • Osteoporosis

    This process involves two enzymes, γ-glutamyl carboxylase and vitamin K epoxide reductase (VKORC1).[ncbi.nlm.nih.gov] 264.7 macrophage cell line (from murine blood)/Er-Xian Decoction treatment In osteoblasts: 8 proteins upregulated Hmgb1, acidic ribosomal phosphoprotein P0, histone H2, carbonyl[doi.org] Miyao M, Morita H, Hosoi T, Kurihara H, Inoue S, Hoshino S, Shiraki M, Yazaki Y, Ouchi Y (2000) Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with[doi.org]

  • Pentosuria

    Human DCXR - another 'moonlighting protein' involved in sugar metabolism, carbonyl detoxification, cell adhesion and male fertility?[ghr.nlm.nih.gov] Abstract Essential pentosuria is the result of a partial deficiency of l -xylulose reductase.[doi.org] Dicarbonyl/L-xylulose reductase (DCXR) Dicarbonyl/L-xylulose reductase (DCXR) UniProt Number: Q7Z4W1 Alternate Names: XR, l-xylulose reductase, kidney dicarbonyl reductase, carbonyl[mitosciences.com]

  • Aldehyde

    For example, the asymmetric allylation and crotylation of aldehydes and other carbonyl compounds remains one of the most fundamental reactions for the construction of chiral[sigmaaldrich.com] Two peaks of reductase activity corresponding to aldose reductase and aldehyde reductase were observed when sympathetic ganglia were chromatofocused.[ncbi.nlm.nih.gov] Carbonylation of Alkynes 3.1. Acrylic Acid from Acetylene 3.2. Other Carbonylation Reactions of Alkynes 4. Carbonylation of Alkenes 4.1. Monoalkenes 4.2.[doi.org]

  • Dihydrofolate Reductase Deficiency

    […] derivatives Heteroaromatic compounds Amino acids Secondary carboxylic acid amides Ketimines Propargyl-type 1,3-dipolar organic compounds Carboxylic acids Azacyclic compounds Carbonyl[hmdb.ca] Dihydrofolic acid reductase deficiency prevents this conversion of folic acid to tetrahydrofolic acid; the enzyme activity appears to differ in each patient.[ncbi.nlm.nih.gov] Based on the current knowledge in patients with SR deficiency peripheral BH4 is synthesized via the salvage pathway catalyzed by the enzymes aldose, carbonyl, and dihydrofolate[biopku.org]

  • Acetohexamide

    The acetohexamide reductase in erythrocyte showed characteristics of carbonyl reductase.[ncbi.nlm.nih.gov] Acetohexamide Catalogue number: A162650 Chemical name: Acetohexamide Synonyms: 4-Acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide; Acetohexamid; Dimelin; Dimelor; Dymelor[trc-canada.com] Acetohexamide-d11 Catalogue number: A162652 Chemical name: Acetohexamide-d11 Synonyms: 4-Acetyl-N-[(cyclohexyl-d11-amino)carbonyl]benzenesulfonamide; Acetohexamid;-d11 Dimelin-d11[trc-canada.com]

  • Lovastatin

    Following an oral dosage, a water molecule does a nuclephilic attack on the carbonyl carbon of the drug and opens the ring, resulting in the beta-hydroxyacid form of lovastatin[community.middlebury.edu] Abstract The HMG-CoA reductase inhibitor, lovastatin, is known to induce asymptomatic liver dysfunction in a few patients.[ncbi.nlm.nih.gov] The moiety crucial for inhibition of the proteasome activity is the β-lactone electrophilic carbonyl, which targets enzymes containing a catalytic nucleophile such as a protease[doi.org]

  • Finasteride

    The treatment (5 h previously) of mice with the 5α-reductase inhibitor SKF 105111 (17β-17-[ bis (1methylethyl) amino carbonyl]; Figure 1 ) resulted in a reduction in the decay[doi.org] Finasteride is the first 5alpha-reductase inhibitor that received clinical approval for the treatment of human benign prostatic hyperplasia (BPH) and androgenetic alopecia[ncbi.nlm.nih.gov] The agent is metabolized to a series of five metabolites, of which two are active and possess less than 20% of the 5 alpha-reductase activity of finasteride.[ncbi.nlm.nih.gov]

  • Tetrahydrobiopterin Deficiency

    […] sepiapterin reductase (SR) Abbreviations: AGMO, alkylglycerol mono-oxygenase; ApoE, apolipoprotein E; AR, aldose reductase; BH4, 6R-L-erythro-5,6,7,8-tetrahydrobiopterin; CR, carbonyl[biochemj.org] Abstract In 1975, dihydropteridine reductase (DHPR) deficiency was first recognized as a cause of tetrahydrobiopterin (BH 4 ) deficiency, leading to hyperphenylalaninemia[doi.org] Dihydropteridine reductase deficiency may be identified positively, and a biopterin value of less than 6.0 micrograms/l in the presence of hyperphenylalaninaemia indicates[ncbi.nlm.nih.gov]

  • Fluvastatin

    […] a Bischler Indole synthesis by cyclisation of a linear precursor under L.A. conditions, avoiding the potential regioselectivity issues of many indole syntheses involving carbonyl[chemistry.stackexchange.com] Product name Fluvastatin sodium salt, HMG-CoA reductase inhibitor Description Competitive HMG-CoA reductase inhibitor Biological description Competitive HMG-CoA reductase[abcam.com] Abstract In this paper, we have investigated the mechanism of phototoxicity of fluvastatin, an 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in human keratinocytes[ncbi.nlm.nih.gov]

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