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175 Possible Causes for Chamorro, Guamanian, or

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  • Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1

    It mainly affects people pertaining to the Chamorro ethnic group living on Guam.[symptoma.com] The cyanobacterial toxin β-N-methylamino- L -alanine (BMAA) now appears to be a cause of Guamanian amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC).[researchers.mq.edu.au] Cycas circinalis, the variety of cycad used by the Chamorro. References: Ince, P.G., Codd, G.A. (2005).[sites.middlebury.edu]

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  • Exposure to Toxin

    Many Chamorros with the disease suffer dementia, and in some villages one-quarter of the adults perished from the disease.[ncbi.nlm.nih.gov] Like Alzheimer's, the causal factors of Guamanian amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) are poorly understood.[ncbi.nlm.nih.gov] […] the formation of both NFT and β-amyloid deposits similar in structure and density to those found in brain tissues of Chamorros who died with ALS/PDC.[ncbi.nlm.nih.gov]

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  • Amyotrophic Lateral Sclerosis 17

    Among the Chamorro people of Guam and people from the Kii Peninsula of Japan, ALS-PDC can be 100 times more frequent than ALS is in other populations.[ghr.nlm.nih.gov] Guamanian amyotrophic lateral sclerosis associated with dementia seems to differ from dementia associated with sporadic or familial types of amyotrophic lateral sclerosis[medlink.com] Males 1:350 Mortality Causes 1 in 700 (350 to 1,000) deaths Rate: 1.9/100,000/year Geography: World-wide distribution General frequency: Uniform Exception: Variants on Guam (Chamorro[neuromuscular.wustl.edu]

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  • Tauopathy

    Perl Abstract Amyotrophic lateral sclerosis/parkinsonism-dementia complex (lytico-bodig) is a chronic neurodegenerative disorder with high prevalence among the native Chamorro[doi.org] Hilton, Seth Love, Ian Ferguson and Piers Newman , Motor neuron disease with neurofibrillary tangles in a non-Guamanian patient , Acta Neuropathologica , 10.1007/BF00294466[dx.doi.org] Also, Guamanian cases with predominant parkinsonism had generally higher neurofibrillary tangle densities than cases with predominant amyotrophic lateral sclerosis.[doi.org]

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  • Amyotrophic Lateral Sclerosis 1

    Among the Chamorro people of Guam and people from the Kii Peninsula of Japan, ALS-PDC can be 100 times more frequent than ALS is in other populations.[ghr.nlm.nih.gov] […] environmental toxins in cycad nut ( Cycas circinalis ): Possibilities include β-Methylamino-L-alanine (BMAA) toxin Consumption of cycad nut containing BMAA toxin Consumption of Guamanian[neuromuscular.wustl.edu] Males 1:350 Mortality Causes 1 in 700 (350 to 1,000) deaths Rate: 1.9/100,000/year Geography: World-wide distribution General frequency: Uniform Exception: Variants on Guam (Chamorro[neuromuscular.wustl.edu]

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  • Amyotrophic Lateral Sclerosis

    Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam. Neurology . 2007 May 22. 68(21):1764-71. [Medline] . Cox PA, Banack SA, Murch SJ.[emedicine.medscape.com] Guamanian: A high incidence of ALS found in Guam and the Trust Territories of the Pacific in the 1950s. MANAGING YOUR ALS[pva.org] Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam. Proc Natl Acad Sci U S A . 2003 Nov 11. 100(23):13380-3.[emedicine.medscape.com]

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  • Motor Neuron Disease

    As well as algae, the toxin is present in cycad seeds - which Chamorro villagers on the Pacific island use to make flour tortillas.[independent.co.uk] ALS Primary Lateral Sclerosis Multifocal Motor Neuropathy Cervical Spondylosis (produces ALS like symptoms, but this one can be ruled out using specific medical testing) Guamanian[baar.com] ALS is subclassified into sporadic (95%), familial (5-10%) and Guamanian ALS-Parkinsonism-Dementia complex 11 .[scielo.br]

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  • Amyotrophic Lateral Sclerosis 10

    Guam ALS is prevalent among the Chamorro Indians of Guam and rare in the United States.[unboundmedicine.com] Guamanian: A high incidence of ALS found in Guam and the Trust Territories of the Pacific in the 1950s. MANAGING YOUR ALS[pva.org]

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  • Amyotrophic Lateral Sclerosis 4

    Among the Chamorro people of Guam and people from the Kii Peninsula of Japan, ALS-PDC can be 100 times more frequent than ALS is in other populations.[ghr.nlm.nih.gov] […] environmental toxins in cycad nut ( Cycas circinalis ): Possibilities include β-Methylamino-L-alanine (BMAA) toxin Consumption of cycad nut containing BMAA toxin Consumption of Guamanian[neuromuscular.wustl.edu] Males 1:350 Mortality Causes 1 in 700 (350 to 1,000) deaths Rate: 1.9/100,000/year Geography: World-wide distribution General frequency: Uniform Exception: Variants on Guam (Chamorro[neuromuscular.wustl.edu]

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  • Degenerative Disorder

    Chamorro inhabitants from the island of Guam in the Pacific Ocean have an increased risk of developing a form of MND known as Guamanian ALS-PD-dementia complex or "lytico[slideshare.net] Chamorro inhabitants from the island of Guam in the Pacific Ocean have an increased risk of developing a form of MND known as Guamanian ALS-PD-dementia complex or "lytico[slideshare.net]

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