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7 Possible Causes for Cholylglycine

  • Extrahepatic Cholestasis

    Taurine conjugates were split with cholylglycine hydrolase and the liberated free bile acids analysed by GC/MS.[] After hydrolysis with cholylglycine hydrolase, the glucuronides of the unconjugated bile acids were separated and identified by GC/MS.[] The isolated conjugates were split either by a combination of acid solvolysis and alkaline hydrolysis or by Helix pomatia and cholylglycine hydrolase.[]

  • Acid Ingestion

    All patients had bile acid malabsorption, as documented by increased breath and fecal excretion of 14C after oral administration of [1-14C] cholylglycine.[]

  • Vegan Diet

    The activity of fecal urease significantly decreased (by 66%) as did cholylglycine hydrolase (55%), beta-glucuronidase (33%) and beta-glucosidase (40%) within 1 wk of beginning[]

  • Vitamin E Deficiency

    Serum vitamin E content and the ratio of serum vitamin E to total serum lipid were very low, but serum vitamin A, cholylglycine, and lipid levels were normal, as was an oral[]

  • Bethanechol

    Gallbladder volume and plasma levels of CCK, PP, motilin, gastrin, neurotensin, cholylglycine were measured regularly.[] In both settings, PP levels were significantly increased after bethanechol, while release of neurotensin, motilin, gastrin and cholylglycine was unaffected.[]

  • Francisella Tularensis

    Genes expressed at a higher level in Ftt when compared to the relatively less virulent Fth included genes encoding isochorismatases, cholylglycine hydrolase, polyamine synthesis[]

  • Alcoholic Hepatitis

    In patients without tissue cholestasis, 66% had elevated serum cholylglycine and 13.5% jaundice.[] In patients with tissue cholestasis, 97% had elevated serum cholylglycine levels, while only 61% had significant jaundice (serum bilirubin 5 mg/dl).[] Highly significant statistical correlations (P 0.0001) were noted between serum cholylglycine levels and the parameters enumerated earlier, but not with survival.[]

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