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441 Possible Causes for Compounds, Inhibitors, Sulfhydryl

  • Influenza

    Compound 2 represents a first-in-class, orally bioavailable, novel compound that offers potential for the treatment of both pandemic and seasonal influenza and has a distinct[] Selected Treatment Trials of Neuraminidase Inhibitors.[] The former has been done for the A/M2 ion channel by combining cysteine scanning mutagenesis and water-soluble sulfhydryl-specific reagents that attach a large hydrophobic[]

  • Sulfonamide

    Sulfonamide , also spelled Sulphonamide , any member of a class of chemical compounds , the amides of sulfonic acids.[] AREAS COVERED IN THIS REVIEW: The article presents the main classes of sulfonamide inhibitors investigated between 2013 and present.[] People who have had allergic reactions to sulfonamide-containing drugs do not need to avoid sulfhydryl drugs, sulfates or sulfites.[]

  • Captopril

    Clinical Data Compound Bioactivity Summary Compound Assay Summary Compound Target Summary Target Predictions The two tables below display ChEMBL single-protein targets which[] Datasheet References Product name Captopril, ACE inhibitor Description Potent ACE inhibitor Biological description Potent ACE inhibitor (IC 50 21 nM).[] ., and with mercaptobenzothiazole (a sulfhydryl group-containing chemical at 1% pet were negative.[]

  • Sulfone

    Polysulfone , any of a class of resinous organic chemical compounds belonging to the family of polymers in which the main structural chain most commonly consists of benzene[] This increased risk was not observed for a sulfonamide COX-2 inhibitor (celecoxib), indicating a potential non-enzymatic mechanism for rofexocib.[] The nucleophilic substitution mechanism further revealed that the compounds were potential reagents for labeling sulfhydryl protein.[]

  • Bicyclomycin

    Bicyclomycin is an old inhibitor of the Rho transcription terminator that by itself shows little rapid lethal activity.[] […] for obtaining such compounds.[] ., a protein sulfhydryl group) necessary for the remodeling the peptidoglycan assembly within the bacterial cell wall.[]

  • Malignant Neoplasm

    Compounds of the inflammatory tumour microenvironment include leukocytes, cytokines, complement components, and are orchestrated by transcription factors, such as NFkB and[] Cyclooxygenase-2 inhibitors and nonnaproxen NSAIDs increase the risk for serious cardiovascular events (relative risk, 1.86 [CI, 1.33 to 2.59] for COX-2 inhibitors vs. placebo[] […] repaired before it is irreversible by the recombination of radicals and dissipation of the associated energy, or it may be modified by agents such as molecular oxygen or sulfhydryl[]

  • Mesna

    To achieve maximal cytoprotection, combinations of selected compounds with sodium 2-mercaptoethane sulphonate (MESNA) were tested.[] False-positive results for ketone with the drug mesna and other free sulfhydryl compounds. Clin Chem 1987 ; 33 : 289 -292.[] Administration of OAT inhibitor probenecid to healthy subjects significantly increased combined mesna and dimesna plasma exposure (91% 34%) while decreasing the renal clearance[]

  • Idiopathic Pulmonary Fibrosis

    Afterwards, this compound was successfully tested in IPF.[] Targeting non-malignant disorders with tyrosine kinase inhibitors. Nat Rev Drug Discov 2010 ;9: 956 - 970 9. Chaudhary NI, Roth GJ, Hilberg F, et al.[] Glutathione (L-gamma-glutamyl-L-cysteinyl-glycine, GSH), a sulfhydryl-containing tripeptide produced by most mammalian cells, is an efficient scavenger of toxic oxidants,[]

  • Alkylating Agent

    Further in vivo tests using these two compounds systemically and/or locally at the tumor site might be warranted.[] Both PARP inhibitors delayed the drop in WST-1 reduction and retained NAD and ATP levels required for apoptosis.[] Bio-Rad offers the following reducing and alkylating reagents: Dithiothreitol (DTT), a commonly used general sulfhydryl reducing agent.[]

  • Zileuton

    The 5-lipoxygenase (5-LO) inhibitor zileuton showed inhibition of LTB(4), LTC(4), and LXA(4) production.[] ChEMBL Molecule Features Mechanism of Action Clinical Data Compound Bioactivity Summary Compound Assay Summary Compound Target Summary Target Predictions The two tables below[] […] it A. supplies sulfhydryl groups to detoxify a reactive metabolite B. induces P450 enzymes to enhance elimination C. blocks the metabolism of acetaminophen D. enhances renal[]