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423 Possible Causes for D, Factor, Properdin

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  • Recurrent Neisseria Infections due to Factor D Deficiency

    An important gene associated with Complement Factor D Deficiency is CFD (Complement Factor D).[] Other elements of the AP are Factor B, Factor D and properdin.[] Jing H, Babu YS, Moore D, Kilpatrick JM, Liu XY, Volanakis JE, Narayana SV. (1998) Structures of native and complexed complement factor D: implications of the atypical His57[]

  • Meningitis

    0.6 mg/kg/d, 4 d No 2 1989 (Lebel) 2 2 1 5 3 months to 16 years Ceph DXM 0.6 mg/kg/d, 4 d No 2 1989 (Girgis) 1 0 0 1 3 months to 70 years Ampi/chlor DXM 16‐24 mg/d, 4 d Yes[] Deficiencies in terminal complement components (eg, membrane attack complex, C5-C9), which increases attack rates but is associated with surprisingly lower mortality rates Properdin[] Multivariate Analysis of Factors Associated with an Unfavorable Outcome.[]

  • Properdin Deficiency

    Nolan KF, Kaluz S, Higgins JMG, Goundis D, Reid KBM: Characterization of the human properdin gene. Biochem J 287:291–297, 1992 Google Scholar 15.[] Properdin deficiency is a rare X-linked disease in which properdin, an important complement factor responsible for the stabilization of the alternative C3 convertase, is deficient[] Sign in Correspondence Free Preview A genetic deficiency of factor B confirms the role of the protein in the activation of the alternative complement pathway in humans and[]

  • Complement Deficiency Syndrome

    Sprong T, Roos D, Weemaes C, et al. (2006) Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene[] CFB, Complement Factor B. CFH, Complement Factor H. CFI, Complement Factor I. C3NeF, C3 Nephritic Factor. CFHA, Complement Factor H auto antibodies.[] Gordon D.[]

  • Immunodeficiency due to a C5 to C9 Complement Component Deficiency

    (rare) -- To view the remaining sections of this topic, please sign in or purchase a subscription -- TY - ELEC T1 - Complement Deficiency ID - 14012 ED - Cabana,Michael D,[] Previous studies have suggested that properdin dysfunction is X-linked, and serogroups B, C, Y, and W-135 have all been isolated from patients with properdin dysfunction during[] B Factor D MBL 5% (Caucasians) Ficolin 3 (H-ficolin) MASP2 C1 inhibitor 1/50,000 C4-binding protein Properdin 100 Factor H 100 FHR1 (FHR3) 100 (5% Caucasians) Factor 1 50[]

  • Atypical Hemolytic-Uremic Syndrome with Anti-Factor H Antibodies

    M , Pruna A , Bordessoule D , Gouilleux V , Scrobohaci ML , Vernant JP , Moreau D , Azoulay E , Schlemmer B , Guillevin L , Lassoued K 2004 Severe ADAMTS13 deficiency in[] These findings implicate other complement components in the same pathway as BF , such as C3 and CFP (encoding properdin), as potential candidate genes contributing to aHUS[] H (FH) and membrane co-factor protein (CD46).[]

  • Hemolytic Uremic Syndrome

    Because of the variable duration of hospitalization, the 28-d sample after discharge was obtained between 33 and 90 d after the onset of D HUS.[] The Properdin system and immunity: V. The bactericidal activity of the properdin system. J Exp Med 1956;103(5):553–575. PubMed CrossRef Google Scholar 107.[] She showed only one cardiovascular risk factor, hypercholesterolaemia.[]

  • Atypical Hemolytic Uremic Syndrome

    Both compounds bind human Factor D with high affinity and effectively inhibit its proteolytic activity against purified Factor B in complex with C3b.[] The same approach was used to model in vitro a potential aHUS treatment approach based on blocking the AP effector properdin (complement factor P; CFP) with an anti-properdin[] She showed only one cardiovascular risk factor, hypercholesterolaemia.[]

  • Hypervitaminosis D

    D but given a toxic dose of vitamin D 50,000 IU (1.25 mg) daily resulting from a dispensing error.[] "DBP (vitamin D binding protein) and BF (properdin factor B) allele distribution in Namibian San and Khoi and in other South African populations.".[] To identify disease risk factors, community-based sex- and age-matched controls were used in a case-control study.[]

  • Membranoproliferative Glomerulonephritis

    The minimum mean urinary protein excretion was 1.4 1.4 g/d at 9 months. There were 2 complete and 3 partial remissions among the 6 patients.[] NFt stabilizes the alternative pathway properdin-dependent C3/C5 convertase (C3Bb2,Bb,P) and leads to C3 activation and consumption.[] Deficiency of factor H, but not factor I, is associated with MPGN2 in humans, pigs, and mice.[]