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5,376 Possible Causes for D, G protein, activation, activity, by, coupled, of, pathway, phospholipase, protein, receptor, signaling

Did you mean: D, proteus, activation, activity, by, cough, of, pathway, phospholipase, proteus, receptor, signaling

  • Pasteurella Multocida

    Initial activation of G alpha-q-coupled phospholipase C-beta-1 signaling by PMT is followed by uncoupling of G alpha-q-dependent signaling, causing downregulation of downstream[] Previous studies have implicated gangliosides as the host receptors for PMT binding.[] Many signaling pathways have been elucidated, however, the effect of these signaling cascades as a means to subvert the host's immune system are just beginning to unravel.[] Downstream of Galpha(q), Galpha(13) and Galpha(i), the toxin activates the small GTPase RhoA, MAP kinases and signal transducer and activator of transcription (STAT) proteins[] […] of the G proteins.[] With the use of G-protein fragments and chimeras of responsive or unresponsive G proteins, the structural basis for the discrimination of heterotrimeric G proteins was studied[] UDP-alpha-D-glucuronate [protein]-3-O-((beta-D-GalNAc-(1- 4)-beta-D-GlcA-(1- 3))(n)-beta-D-GalNAc-(1- 4)-beta-D-GlcA-(1- 3)-beta-D-Gal-(1- 3)-beta-D-Gal-(1- 4)-beta-D-Xyl)[] […] that in a large number of bacteria the main path for carbohydrate oxidation is the pentose phosphate cycle or other metabolic sequences not involving the Embden–Meyerhof pathway[] Interestingly, endogenous SOCS-1 production after Toll-like receptor activation also causes STAT3 hyperactivation.[] In addition to standard therapy, the patient was managed with drotrecogin alpha (activated) recombinant activated protein C (APC), an evidence-based agent that has been shown[]

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  • Echinococcus Granulosus

    Involvement of the protein and phospholipid moieties in EgAgB binding to cells was analysed employing lipid-free recombinant EgAgB subunits and phospholipase D treated-EgAgB[] The receptor also bound the Echinococcus multilocularis LL.[] Calcineurin (CaN) is a Ca(2 )-calmodulin activated serine-threonine protein phosphatase that couples the local or global calcium signals, thus controlling important cellular[] Based on the ultrasonography images, CE patients were further categorized as being in "active stages" (25) and "inactive stages" (17).[] Lipids are mainly solubilized by various families of lipid binding proteins which participate in their transport between tissues as well as cell compartments.[] In this study, we investigated AgB interactions with different mammalian cell types and the pathways involved in its internalization.[] An inductively coupled plasma atomic emission spectrometer (ICP-AES) was used to determine the elements, an automatic biochemical analyzer was used to detect the types and[] Buffer PBS (pH 7.2) Preservative 0.09% Sodium Azide Purity Protein G purified Alternate Names for Echinococcus Granulosus Antibody (EHG) Background Echinococcus granulosis[] Our results indicate that the laminated layer protects E. granulosus against the NOS2 protective response through Arginase pathway, a hallmark of M2 macrophages.[] Haplotype diversity and nucleotide diversity were low, while negative values were observed for Tajima's D and Fu's Fs.[]

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  • Sambucus

    Aristolochic acid (a phospholipase A2 inhibitor), indomethacin (a cyclooxygenase inhibitor), neomycin sulfate (a phospholipase C inhibitor), trifluoperazine (a calmodulin[] Sambucus nigra lectin has high affinity for SA-α-2,6-Gal receptors.[] In this study, we isolated (-)-olivil-9'-O-β-d-glucopyranoside (OLI9G), a phytochemical from the stem bark of Sambucus williamsii, and investigated the antifungal mechanism[] S. ebulus extract at the concentration of 100 mg/ml for 60 minutes had the most anti-giardial activity (78 4%) than other concentrations.[] […] ricin inhibiting protein synthesis in cell-free extracts, they lack the high toxicity of ricin and related type 2 RIPs to intact cells and animals.[] So of course, I decided to plant a couple near my garden![] Hapten inhibition experiments showed that both D-Gal and D-GalNAc are weak inhibitors of SNA-glycophorin precipitation, but neither New5Ac nor Neu5Gc is an inhibitor.[] Further, SNA activates the signaling pathways of AKT and ERK1/2, which eventually promotes de-phosphorylation of dynamin-related protein-1 (Drp-1).[] Therefore, the present study suggests that lariciresinol possesses fungicidal activities by disrupting the fungal plasma membrane and therapeutic potential as a novel antifungal[] However, it is inactive against plant and HeLa cells protein synthesis.[]

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  • Francisella Tularensis

    We previously demonstrated that PGE(2) synthesis by F. tularensis-infected macrophages requires cytosolic phospholipase A2 (cPLA(2)), cyclooxygenase 2 (COX-2), and microsomal[] Small molecules were developed to attenuate proinflammatory cytokines resulting from activation of MyD88-mediated toll-like receptor (TLR) signaling by Francisella tularensis[] Seventeen compounds from two different frameworks, designated the D and Q series, display antibacterial activities with MICs of 1 μM.[] However, it has been unclear whether the virulent Schu S4 was merely evading or actively suppressing monocyte responses.[] Bacterial outer membrane proteins (OMPs) are involved in various virulence processes, including protein secretion, host cell attachment, and intracellular survival.[] Gene and pathway analysis identified processes involved in MMP modulation, endocytosis, mucin production and the complement pathway amongst others.[] The fact that a very small inoculum delivered by the aerosol route can cause severe disease, coupled with the possibility of its use as an aerosolized bioweapon, has led to[] Buffer PBS (pH 7.4) Preservative 0.09% Sodium Azide Purity Protein G purified Alternate Names for Francisella Tularensis LPS Antibody (FB11) Lipopolysaccharide protein Lipopolysaccharide[] According to this concept, the type of cell and its receptor(s) that initially interact with the target constitute the first signaling window; the signals produced in the[] Marrero and D. Raoult, Am. J. Trop. Med. Hyg. 40:197-199, 1989) resulted in the recovery of a bacterium.[]

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  • Ehrlichia Chaffeensis

    […] methoxyphenethyl]-1H-imidazole (SKF-96365) (calcium channel inhibitors), neomycin and 1-(6-[[17beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl)-1H-pyrrole-2,5-dione (U-73122) (phospholipase[] A luciferase reporter assay using HEK293 cells, which lack Toll-like receptors (TLRs), showed activation of both the IL-8 promoter and NF-κB by E. chaffeensis.[] In this study, we investigated the effects of c-di-GMP signaling on E. chaffeensis infection of the human monocytic cell line THP-1.[] E. chaffeensis was found to be present in 9.8% of adult A. americanum ticks (57 of 579) and 6.7% of D. variabilis ticks (eight of 120).[] We linked Notch pathway activation specifically to the TRP120 effector, which directly interacts with the Notch metalloprotease ADAM17.[] Additional E. chaffeensis surface proteins detected were OMP85, hypothetical protein ECH_0525 (here named Esp73), immunodominant surface protein gp47, and 11 other proteins[] […] group ring finger protein 5 (PCGF5) to the inclusion, indicating that the SUMO pathway is critical for intracellular survival.[] This suggests that TRP120 folds into an ordered structure upon forming a protein-DNA complex, and thus folding of TRP120 TR is coupled with DNA binding.[] . & Montelione, G. (2007). Proteins , 66 , 778–795. Web of Science CrossRef PubMed CAS Google Scholar Buchko, G. W., Clifton, M. C., Wallace, E. G., Atkins, K.[] The entry of these bacteria requires host phospholipase C (PLC)-gamma2 and protein tyrosine kinases, but their entry route is still unclear.[]

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  • Isoproterenol

    These studies have shown that while HIF cells express FP prostaglandin and histamine receptors coupled to phospholipase C to produce [(3)H]-IPs, the HIM cells lack such functionally[] Isoproterenol-induced DNA strand breaks could be partially prevented by pre-treatment with the β-adrenergic receptor antagonist propranolol.[] […] of the two signaling pathways was the same.[] Sprague-Dawley (SD) rats were treated with Iso (10mg/kg/d) alone or in combination with AsIV (50mg/kg/d).[] We hypothesized that molecules exist that act as biased agonists to selectively activate this pathway.[] Electrophysiological evaluation in the control state demonstrated a single, left posterior free-wall atrioventricular accessory pathway.[] […] s)alpha and beta(2)AR-G(s)alpha fusion proteins.[] Sympathetic tone regulates myocardial calcium transients through β-adrenergic receptor (β-AR)-mediated phosphorylation of dyadic proteins.[] Kleinau G, Pratzka J, Nürnberg D, Grüters A, Führer-Sakel D, Krude H, Köhrle J, Schöneberg T, Biebermann H (October 2011).[] Our previous study showed that hHole was strongly expressed in adult heart and may act as a suppressor of extracellular signal-regulated kinases (ERKs), overactivation of[]

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  • Neuroepithelioma

    Northern blot analysis of SK-N-MC mRNA using cDNA probes for the beta 1- and beta 2-adrenergic receptors revealed the presence of a very strong beta 1-adrenergic receptor[] G protein-coupled receptors (GPCRs) are critical players in converting extracellular stimuli into intracellular signals.[] GCS inhibition, by both antisense and the specific inhibitor (D-threo)-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), results in a drastic decrease of apoptosis[] Nevertheless, activation of all three receptor tyrosine kinases led to ERK2 activation.[] We have recently found that the proliferation of a neoplastic Schwann cell line is dependent on constitutive activation of the NRG-1/erbB signaling pathway and that overexpression[] Lysophosphatidic acid (LPA) and endothelin-1 (ET-1), two ligands for G-protein coupled receptors (GPCRs), induce activation of mitogen activated protein kinase (MAPK).[] Péoc'h, D. Pasquier, D. Plantaz, D. Leroux and B.[] Activation of both cAMP and PKC second messenger pathways increased CCK mRNA levels in SK-N-MCIXC cells.[] The protein phosphatase inhibitor okadaic acid (OA) dose-dependently induced apoptosis in CHP-100 neuroepithelioma cells when administered for 24 h at concentrations ranging[] These results demonstrate that NPY binds specifically to a G protein-linked receptor that inhibits adenylate cyclase in SK-N-MC cells.[]

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  • Clonorchis Sinensis

    Although prior studies confirmed that group III secretory phospholipase A2 of Clonorchis sinensis (CsGIIIsPLA2) had stimulating effect on liver fibrosis by binding to LX-2[] Growth factor receptor-bound protein 2 (Grb2) is a cytosolic protein conserved among animals and plays roles in cellular functions such as meiosis, organogenesis and energy[] Increasing evidence shows that 14-3-3 proteins are involved in many biology events in addition to signal transduction.[] Cs-α-NAGAL belongs to the GH27 family and the GH-D clan.[] We examined the reciprocal regulation of two ESP-induced redox-active proteins, NF-κB and peroxiredoxin 6 (Prdx6), during C. sinensis infection.[] We identified antigenic proteins from adult C. sinensis liver flukes using immunoproteomic analysis.[] IL-25 and members of its associated signaling pathway were detected by performing quantitative real-time PCR, Western blotting and immunofluorescent staining.[] However, we also found that CsPmy is able to bind to human immunoglobulin G (IgG) in non-specific manners, which can affect the diagnostic value of the protein.[] Lysophospholipase, belonging to the complex family of phospholipases, is supposed to play a vital role in virulence and pathogenesis of parasites and fungi.[] Here, we report a multiplex real-time PCR coupled with high resolution melting (HRM) analysis for the differentiation of O. viverrini and C. sinensis eggs in fecal samples[]

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  • Thyrotropin

    However, this mutation also caused a reduction in the activation capacity of the Gq/11-phospholipase C pathway, compared with the wild type.[] The thyrotropin receptor (TSHR) is a G protein-coupled receptor (GPCR) that is member of the leucine-rich repeat subfamily (LGR).[] We conclude that TSH regulates expression of different bone markers via distinct signaling pathways.[] It is unclear whether seasonal variations in vitamin D concentrations affect the hypothalamo-pituitary-thyroid axis.[] ECL1) interface is a critical step in receptor activation.[] Product name Recombinant Human Thyrotropin Releasing Hormone (TRH) protein Protein length Full length protein Nature Recombinant Source Wheat germ Amino Acid Sequence Species[] Surface-enhanced resonance Raman scattering (SERRS) has been used to establish a rapid and quantitative assay based on the diazotization coupling reaction for thyrotropin-releasing[] The TSH receptor (TSHR), a member of the large family of G protein-coupled receptors, controls both function and growth of thyroid cells; hence, mutations of this receptor[] Natural variant i VAR_075585 432 N D in CHNG1; abolishes cell membrane location; abolishes adenylate cyclase-activating G-protein coupled receptor signaling pathway; abolishes phospholipase[] In the past, it was assumed that thyroid hyperplasia is due to constitutive activation of the Gs/adenylyl cyclase signaling pathway; however, the physiological role of the[]

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  • Carbachol

    […] cells may be due, at least in part, to inhibition of the formation of the PKC zeta activator phosphatidic acid (PA), which is formed by hydrolysis of phosphatidylcholine by phospholipase[] The molecular mechanisms involved in the regulation of muscarinic receptor gene expression are poorly understood.[] CCh induced TGF-β1 self-sustaining signaling loops by potentiating ERK5 signaling and promoted myofibroblast activity.[] This study demonstrated that c-Src 1) activity is necessary for [Ca(2 )]i inhibition of NHE3 activity, 2) activation occurs rapidly ( 1 min) after CCh treatment, 3) directly[] The TAO (for thousand-and-one amino acids) protein kinases activate p38 mitogen-activated protein (MAP) kinase cascades in vitro and in cells by phosphorylating the MAP/ERK[] These findings imply that GPCR activation induces p70S6K1 via ERK rather than through the canonical PI 3-kinase/Akt/TSC/mTORC1 pathway in T84 colon carcinoma cells.[] These results show that the Galphai-2 protein couples muscarinic receptors to stress fiber formation in ASM.[] To determine whether M2 muscarinic receptors are linked to the monomeric G protein Rho, we studied the effect of carbachol on actin reorganization (stress fiber formation)[] Surprisingly, phospholipase C or protein kinase C do not seem to be involved to a relevant extent.[] In this report we demonstrate the coupling of m3 muscarinic receptors to the activation of a voltage-insensitive, cation-selective channel of low conductance (3.2 /- 0.6 pS[]

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